Richard Locksley, MD

Sandler Distinguished Professor

Dr. Locksley is the Director of the Sandler Asthma Basic Research Center (SABRE) and a Howard Hughes Medical Institute Investigator. He is a Professor in the Departments of Medicine and Microbiology & Immunology. He received his undergraduate degree in biochemistry from Harvard and his M.D. from the University of Rochester. After completing his residency at UCSF, he trained in infectious diseases at the University of Washington. Prior to his position as director of the SABRE Center, Dr. Locksley served 18 years as the Chief of the Division of Infectious Diseases at UCSF Medical Center. Dr. Locksley is a fellow of the American Academy of Arts and Sciences and member of the National Academy of Sciences.

Dr. Locksley's laboratory addresses the immune cells and tissue responses that occur during allergic, or type 2, immunity. This includes the processes by which naïve helper T cells differentiate to become allergy-supporting Th2 cells, but also the interactions of these cells with eosinophils, basophils, mast cells and alternatively activated macrophages that mediate activities in peripheral tissues. The laboratory increasingly focuses on innate immunity, particularly since the discovery of Group 2 innate lymphoid cells, or ILC2s, which are prominently involved in allergy. Importantly, the discovery of ILC2s initiated efforts to uncover the ‘ground state’ of allergy by investigating homeostatic pathways involving these cells that might provide insights regarding their primary function in the immune system and in homeostasis.

Dr. Locksley’s laboratory pioneered the use of mice genetically engineered to report cytokines expressed during allergic immune responses. Using these methods, the laboratory participated in the discovery of innate lymphoid type 2 cells, or ILC2s, which represent a previously unknown cell now implicated in allergic immunity. The ability to study the activation and organization of innate ILC2s uncovered a role for cells associated with allergy and asthma, such as eosinophils, in processes involved with basal metabolism and tissue homeostasis. Activation of ILC2s in the small intestine was implicated in alteration of the mucosa to a secretory phenotype characterized by high numbers of goblet cells and tuft cells. The latter, a previously mysterious epithelial cell of unknown function, was shown to be the source of IL-25, a cytokine capable of activating ILC2s and other immune cells associated with allergy and asthma, thus opening up entirely new avenues for discovery.
Education
1980-83 - Infect Diseases Fellow, University of Washington
1976-80 - Resident/Chief Resident, University of California, San Francisco
M.D., 06/1976 - Medicine, University of Rochester
B.A., 06/1970 - Biochemistry, Harvard College
Honors and Awards
  • Fellow, American Academy of Microbiology, 2017
  • Inaugural William Paul Award for Cytokine Research, International Cytokine & Interferon Society, 2017
  • National Academy of Sciences, 2017
  • Thomson Reuters ‘Top 1% highly cited researchers in immunology’, 2014
  • R37 MERIT Award, NIAID/NIH, 2006
  • American Academy of Arts & Sciences, 2005
  • Distinguished Service Award, American Association of Immunologists, 2003
  • Inspirational Teacher Award, UCSF class of 2006, 2003
  • Sandler Distinguished Professorship, 2003
  • Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2001-2005
  • Association of American Physicians, 1994
  • Bailey K Ashford Medal, American Society Tropical Medicine and Hygiene, 1994
  • Burroughs Wellcome Fund Scholar in Molecular Parasitology, 1992-1997
  • Fellow, Infectious Diseases Society of American, 1992
  • American Society for Clinical Investigation, 1991
Publications

  1. Liao C, Mennillo E, Kattah MG, Ji M, Wang ZE, Drucker DJ, Liang HE, Locksley RM. TSLP links intestinal nutrient sensing with amplification of the ILC2-tuft cell circuit. 2025. PMID: 41225178


  2. Cortez VS, Viragova S, Koga S, Liu M, O'Leary CE, Ricardo-Gonzalez RR, Schroeder AW, Kochhar N, Vaka D, Boffelli D, Klein OD, Diamond MS, Liang HE, Locksley RM. IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity. 2025. PMID: 40914159


  3. Sun IH, Qualls AE, Yin HS, Wang J, Arvedson MP, Germino J, Horner NK, Zhong S, Du J, Valdearcos M, Ntranos V, Locksley RM, Ricardo-Gonzalez RR, Gardner JM. ROR?t eTACs mediate oral tolerance and Treg induction. 2025. PMID: 40298935


  4. Lee Y, Ishikawa T, Lee H, Lee B, Ryu C, Davila Mejia I, Kim M, Lu G, Hong Y, Feng M, Shin H, Meloche S, Locksley RM, Koltsova E, Grivennikov SI, Heiman M, Choi GB, Huh JR. Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB. 2025. PMID: 40199322


  5. Cortez VS, Viragova S, Koga S, Liu M, O'Leary CE, Ricardo-Gonzalez RR, Schroeder AW, Kochhar N, Klein OD, Diamond MS, Liang HE, Locksley RM. IL-25-induced memory ILC2s mediate long-term small intestinal adaptation. 2025. PMID: 40196473


  6. Jung H, Kim DH, Díaz RE, White JM, Rucknagel S, Mosby L, Wang Y, Reddy S, Winkler ES, Hassan AO, Ying B, Diamond MS, Locksley RM, Fraser JS, Van Dyken SJ. An ILC2-chitinase circuit restores lung homeostasis after epithelial injury. 2024. PMID: 39423283


  7. Liao C, Ji M, Wang ZE, Drucker DJ, Liang HE, Locksley RM. Telocytes link epithelial nutrient sensing with amplification of the ILC2-tuft cell circuit. 2024. PMID: 39463951


  8. Schuijs MJ, Brenis Gomez CM, Bick F, Van Moorleghem J, Vanheerswynghels M, van Loo G, Beyaert R, Voehringer D, Locksley RM, Hammad H, Lambrecht BN. Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue. 2024. PMID: 39297875


  9. Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken S, Locksley RM, Fraser JS. Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. 2024. PMID: 38884443


  10. Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS. Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. 2023. PMID: 37398339


  11. Rekima A, van den Elsen L, Isnard C, Smyth DJ, Lynn MA, Yee T, Stevens NE, Machado S, Divakara N, Bhasin M, Tjiam MC, Rowel C, Servant F, Burcelin R, Locksley R, Maizels R, Lynn DJ, Egwang T, Verhasselt V. Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti-helminth defences. 2024. PMID: 38348877


  12. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. 2024. PMID: 38321203


  13. O'Keefe RN, Carli ALE, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, Eissmann MF, Poh AR, Pal B, Seillet C, Locksley RM, Ernst M, Buchert M. A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development. 2023. PMID: 37898600


  14. Shaikh N, Waterhölter A, Gnirck AC, Becker M, Adamiak V, Henneken L, Wunderlich M, Hartmann W, Linnemann L, Huber TB, Krebs CF, Panzer U, Locksley RM, Wilhelm C, Breloer M, Turner JE. Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites. 2023. PMID: 37773047


  15. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. 2023. PMID: 37790430


  16. Fahy JV, Locksley RM. Immune treatment tackles chronic obstructive pulmonary disease. 2023. PMID: 37587279


  17. Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. 2023. PMID: 37163060


  18. Molofsky AB, Locksley RM. The ins and outs of innate and adaptive type 2 immunity. 2023. PMID: 37044061


  19. Kotas ME, O'Leary CE, Locksley RM. Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage. 2022. PMID: 36351364


  20. Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. 2022. PMID: 36044899


  21. Kotas ME, Moore CM, Gurrola Ii JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED. IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function. 2022. PMID: 35608904


  22. O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM. Bile acid-sensitive tuft cells regulate biliary neutrophil influx. 2022. PMID: 35245089


  23. Ricardo-Gonzalez RR, Molofsky AB, Locksley RM. ILC2s - development, divergence, dispersal. 2022. PMID: 35176675


  24. Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. 2022. PMID: 35139352


  25. Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS. Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1. 2021. PMID: 34652961


  26. Gschwend J, Sherman SPM, Ridder F, Feng X, Liang HE, Locksley RM, Becher B, Schneider C. Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth. 2021. PMID: 34431978


  27. Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone. 2021. PMID: 34290377


  28. O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C. Corrections. 2021. PMID: 34242484


  29. Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B. A role for IL-33-activated ILC2s in eosinophilic vasculitis. 2021. PMID: 33974563


  30. Kastenschmidt JM, Coulis G, Farahat PK, Pham P, Rios R, Cristal TT, Mannaa AH, Ayer RE, Yahia R, Deshpande AA, Hughes BS, Savage AK, Giesige CR, Harper SQ, Locksley RM, Mozaffar T, Villalta SA. A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression. 2021. PMID: 33852849


  31. O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C. Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo Manipulations. 2021. PMID: 33740294


  32. Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA. Skin-resident innate lymphoid cells converge on a pathogenic effector state. 2021. PMID: 33536623


  33. Zeis P, Lian M, Fan X, Herman JS, Hernandez DC, Gentek R, Elias S, Symowski C, Knöpper K, Peltokangas N, Friedrich C, Doucet-Ladeveze R, Kabat AM, Locksley RM, Voehringer D, Bajenoff M, Rudensky AY, Romagnani C, Grün D, Gasteiger G. In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors. 2020. PMID: 33002412


  34. Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM. Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity. 2020. PMID: 32031571


  35. Molofsky AB, Locksley RM. Tissue immunity broadcasts near and far. 2019. PMID: 31748703


  36. Barad BA, Liu L, Diaz RE, Basilio R, Van Dyken SJ, Locksley RM, Fraser JS. Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates. 2020. PMID: 31930591


  38. Schneider C, O'Leary CE, Locksley RM. Regulation of immune responses by tuft cells. 2019. PMID: 31114038


  39. Fahy JV, Locksley RM. Making Asthma Crystal Clear. 2019. PMID: 31461600


  40. Ricardo-Gonzalez RR, Locksley RM. ILC2s chew the fat. 2019. PMID: 31405894


  41. Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. 2019. PMID: 31128962


  43. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Volume 562 of Issue 7727. 2018. PMID: 30013120


  44. Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. Tissue signals imprint ILC2 identity with anticipatory function. 2018. PMID: 30201992


  45. Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H. Innate Lymphoid Cells: 10 Years On. Volume 174 of Issue 5. 2018. PMID: 30142344


  46. Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. 2018. PMID: 30022164


  47. Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. 2018. PMID: 30021144


  48. Van Dyken SJ, Locksley RM. Chitins and Chitinase Activity in Airway Diseases. Volume 142 of Issue 2. 2018. PMID: 29959948


  49. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Volume 559 of Issue 7712. 2018. PMID: 29950724


  50. Kotas ME, Locksley RM. Why Innate Lymphoid Cells? Volume 48 of Issue 6. 2018. PMID: 29924974


  51. Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Volume 174 of Issue 2. 2018. PMID: 29887373


  52. Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. Pulmonary neuroendocrine cells amplify allergic asthma responses. Volume 360 of Issue 6393. 2018. PMID: 29599193


  53. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Volume 171 of Issue 7. 2017. PMID: 29245014


  54. Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM. MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. Volume 214 of Issue 12. 2017. PMID: 29122948


  55. Locksley R. Turning the light on. Volume 17 of Issue 10. 2017. PMID: 28757606


  56. Savage AK, Liang HE, Locksley RM. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. Volume 199 of Issue 5. 2017. PMID: 28747343


  57. Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Volume 21 of Issue 1. 2017. PMID: 28506464


  58. Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Volume 169 of Issue 3. 2017. PMID: 28431248


  59. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. Volume 214 of Issue 1. 2016. PMID: 28011865


  60. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. Volume 11 of Issue 12. 2016. PMID: 27977701


  61. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. A tissue checkpoint regulates type 2 immunity. Volume 17 of Issue 12. 2016. PMID: 27749840


  62. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Volume 166 of Issue 4. 2016. PMID: 27453471


  63. Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. Volume 1 of Issue 10. 2016. PMID: 27525310


  64. Gordon ED, Locksley RM, Fahy JV. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Volume 193 of Issue 9. 2016. PMID: 27128698


  65. von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Volume 529 of Issue 7585. 2015. PMID: 26675736


  66. Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Volume 9 of Issue 1. 2015. PMID: 26129648


  67. Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. Interleukin-33 and Interferon-? Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Volume 43 of Issue 1. 2015. PMID: 26092469


  68. Molofsky AB, Savage AK, Locksley RM. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Volume 42 of Issue 6. 2015. PMID: 26084021


  69. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. Volume 7 of Issue 288. 2015. PMID: 25995219


  70. Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D. Eosinophil-specific deletion of I?Ba in mice reveals a critical role of NF-?B-induced Bcl-xL for inhibition of apoptosis. Volume 125 of Issue 25. 2015. PMID: 25862560


  71. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. Volume 212 of Issue 4. 2015. PMID: 25779634


  72. Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM. A novel model for IFN-?-mediated autoinflammatory syndromes. Volume 194 of Issue 5. 2015. PMID: 25637019


  73. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Volume 160 of Issue 1-2. 2014. PMID: 25543153


  74. Bando JK, Liang HE, Locksley RM. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Volume 16 of Issue 2. 2014. PMID: 25501629


  75. Cheng LE, Locksley RM. Allergic inflammation--innately homeostatic. Volume 7 of Issue 3. 2014. PMID: 25414367


  76. Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Volume 124 of Issue 24. 2014. PMID: 25323825


  77. von Moltke J, Locksley RM. I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis. Volume 31. 2014. PMID: 25458996


  78. Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Volume 157 of Issue 6. 2014. PMID: 24906148


  79. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. Volume 211 of Issue 7. 2014. PMID: 24889202


  80. O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP. Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection. Volume 82 of Issue 8. 2014. PMID: 24842927


  81. Locksley RM, Fahy JV. Asthma and the flu: a tricky two-step. Volume 92 of Issue 5. 2014. PMID: 24687019


  82. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Volume 40 of Issue 3. 2014. PMID: 24631157


  83. Hams E, Locksley RM, McKenzie AN, Fallon PG. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. Volume 191 of Issue 11. 2013. PMID: 24166975


  84. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Volume 502 of Issue 7470. 2013. PMID: 24037376


  85. Bando JK, Nussbaum JC, Liang HE, Locksley RM. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. Volume 94 of Issue 5. 2013. PMID: 23924659


  86. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Volume 43 of Issue 8. 2013. PMID: 23630120


  87. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. Eosinophils secrete IL-4 to facilitate liver regeneration. Volume 110 of Issue 24. 2013. PMID: 23716700


  88. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Volume 153 of Issue 2. 2013. PMID: 23582327


  89. Locksley RM. Raggin' on T-bet. Volume 17 of Issue 4. 2013. PMID: 23562073


  90. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. Volume 210 of Issue 3. 2013. PMID: 23420878


  91. Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E. Innate lymphoid cells--a proposal for uniform nomenclature. Volume 13 of Issue 2. 2013. PMID: 23348417


  92. Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. Volume 190 of Issue 5. 2013. PMID: 23338236


  94. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Volume 38 of Issue 1. 2013. PMID: 23290520


  95. Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. Volume 92 of Issue 5. 2012. PMID: 22941735


  96. Price AE, Reinhardt RL, Liang HE, Locksley RM. Marking and quantifying IL-17A-producing cells in vivo. Volume 7 of Issue 6. 2012. PMID: 22768117


  97. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. Volume 209 of Issue 6. 2012. PMID: 22585735


  98. Nussbaum JC, Locksley RM. Infectious (Non)tolerance--frustrated commensalism gone awry? Volume 4 of Issue 5. 2012. PMID: 22456498


  99. Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Volume 13 of Issue 1. 2011. PMID: 22138715


  100. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Volume 480 of Issue 7375. 2011. PMID: 22101429


  101. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. Deletion of Syk in neutrophils prevents immune complex arthritis. Volume 187 of Issue 8. 2011. PMID: 21918195


  102. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. A protective role for periostin and TGF-ß in IgE-mediated allergy and airway hyperresponsiveness. Volume 42 of Issue 1. 2011. PMID: 22093101


  103. Fahy JV, Locksley RM. The airway epithelium as a regulator of Th2 responses in asthma. Volume 184 of Issue 4. 2011. PMID: 21844510


  104. Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM. Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. Volume 187 of Issue 5. 2011. PMID: 21824866


  105. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Volume 12 of Issue 6. 2011. PMID: 21552267


  106. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Volume 332 of Issue 6026. 2011. PMID: 21436399


  107. Svensson M, Bell L, Little MC, DeSchoolmeester M, Locksley RM, Else KJ. Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection. 2011. PMID: 21155838


  108. Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Volume 107 of Issue 52. 2010. PMID: 21149710


  109. Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW. Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. Volume 4 of Issue 3. 2010. PMID: 20980996


  110. Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, Liu L. Lymphocyte development requires S-nitrosoglutathione reductase. Volume 185 of Issue 11. 2010. PMID: 20980633


  111. Cheng LE, Wang ZE, Locksley RM. Murine B cells regulate serum IgE levels in a CD23-dependent manner. Volume 185 of Issue 9. 2010. PMID: 20870945


  112. Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Volume 107 of Issue 25. 2010. PMID: 20534524


  113. Locksley RM. Asthma and allergic inflammation. Volume 140 of Issue 6. 2010. PMID: 20303868


  114. Barbalat R, Lau L, Locksley RM, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Volume 10 of Issue 11. 2009. PMID: 19801985


  115. Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Volume 31 of Issue 2. 2009. PMID: 19682930


  117. Locksley RM. Nine lives: plasticity among T helper cell subsets. Volume 206 of Issue 8. 2009. PMID: 19635860


  118. Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A. In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. Volume 182 of Issue 11. 2009. PMID: 19454688


  119. Kroeger KM, Sullivan BM, Locksley RM. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. Volume 86 of Issue 4. 2009. PMID: 19451398


  120. Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. Volume 284 of Issue 29. 2009. PMID: 19435888


  121. Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Volume 10 of Issue 4. 2009. PMID: 19252490


  122. Kang SJ, Locksley RM. The inflammasome and alum-mediated adjuvanticity. Volume 1. 2009. PMID: 20948671


  123. Sullivan BM, Locksley RM. Basophils: a nonredundant contributor to host immunity. Volume 30 of Issue 1. 2009. PMID: 19144314


  125. Kang SJ, Liang HE, Reizis B, Locksley RM. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Volume 29 of Issue 5. 2008. PMID: 19006696


  126. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. Volume 181 of Issue 8. 2008. PMID: 18832694


  127. Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. Volume 181 of Issue 8. 2008. PMID: 18832714


  128. Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Volume 135 of Issue 1. 2008. PMID: 18854153


  129. Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Volume 29 of Issue 1. 2008. PMID: 18585064


  130. Voehringer D, Liang HE, Locksley RM. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. Volume 180 of Issue 7. 2008. PMID: 18354198


  131. Locksley RM. The Roaring Twenties. Volume 28 of Issue 4. 2008. PMID: 18400185


  132. Van Dyken SJ, Locksley RM. Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity. Volume 85 of Issue 8. 2007. PMID: 17909561


  133. Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Volume 317 of Issue 5838. 2007. PMID: 17673664


  134. Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C. A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. Volume 179 of Issue 2. 2007. PMID: 17617602


  135. Launois P, Pingel S, Himmelrich H, Locksley R, Louis J. Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major. Volume 9 of Issue 11. 2007. PMID: 17890126


  136. Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Volume 447 of Issue 7140. 2007. PMID: 17450126


  137. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Volume 8 of Issue 4. 2007. PMID: 17351619


  138. Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley RM. Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Volume 116 of Issue 4. 2007. PMID: 17420014


  139. Voehringer D, van Rooijen N, Locksley RM. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. Volume 81 of Issue 6. 2007. PMID: 17339609


  140. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Volume 203 of Issue 13. 2006. PMID: 17158962


  141. Locksley RM. A failure to launch: fuelling cytokine secretion in iNKT cells. Volume 25 of Issue 3. 2006. PMID: 16979571


  142. Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. Volume 116 of Issue 8. 2006. PMID: 16886063


  143. Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. Volume 177 of Issue 3. 2006. PMID: 16849470


  144. Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J. LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. Volume 36 of Issue 6. 2006. PMID: 16637008


  145. Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. Volume 203 of Issue 6. 2006. PMID: 16702603


  146. Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM. Activation of the integrated stress response during T helper cell differentiation. Volume 7 of Issue 6. 2006. PMID: 16680145


  147. Hayashida T, Oda M, Ohsawa K, Yamaguchi A, Hosozawa T, Locksley RM, Giacca M, Masai H, Miyatake S. Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence. Volume 176 of Issue 9. 2006. PMID: 16622012


  148. Reinhardt RL, Kang SJ, Liang HE, Locksley RM. T helper cell effector fates--who, how and where? Volume 18 of Issue 3. 2006. PMID: 16617008


  149. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Volume 24 of Issue 2. 2006. PMID: 16473830


  150. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Volume 7 of Issue 1. 2005. PMID: 16311599


  151. Im W, Kim H, Yun D, Seo SY, Park SH, Locksley RM, Hong S. Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds. Volume 20 of Issue 2. 2005. PMID: 16267405


  152. Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Volume 23 of Issue 4. 2005. PMID: 16226507


  153. Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP. Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection. Volume 102 of Issue 28. 2005. PMID: 15994233


  154. Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C. Interleukin-4 can be a key positive regulator of inflammatory arthritis. Volume 52 of Issue 6. 2005. PMID: 15934072


  156. Voehringer D, Rosen DB, Lanier LL, Locksley RM. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. Volume 279 of Issue 52. 2004. PMID: 15471863


  157. Xu M, Wang Z, Locksley RM. Innate immune responses in peptidoglycan recognition protein L-deficient mice. Volume 24 of Issue 18. 2004. PMID: 15340057


  158. Voehringer D, Shinkai K, Locksley RM. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Volume 20 of Issue 3. 2004. PMID: 15030771


  159. Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM. Th2 cells: orchestrating barrier immunity. Volume 83. 2004. PMID: 15135631


  160. Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley RM. Basal chromatin modification at the IL-4 gene in helper T cells. Volume 171 of Issue 12. 2003. PMID: 14662870


  161. Kelly BL, Stetson DB, Locksley RM. Leishmania major LACK antigen is required for efficient vertebrate parasitization. Volume 198 of Issue 11. 2003. PMID: 14657221


  162. Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. Volume 198 of Issue 7. 2003. PMID: 14530376


  163. Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Volume 100 of Issue 14. 2003. PMID: 12829795


  164. Hadeiba H, Locksley RM. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. Volume 170 of Issue 11. 2003. PMID: 12759427


  165. Mohrs M, Lacy DA, Locksley RM. Stat signals release activated naive Th cells from an anergic checkpoint. Volume 170 of Issue 4. 2003. PMID: 12574353


  166. Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Volume 4 of Issue 2. 2003. PMID: 12524538


  167. Shinkai K, Mohrs M, Locksley RM. Helper T cells regulate type-2 innate immunity in vivo. Volume 420 of Issue 6917. 2002. PMID: 12490951


  168. Locksley RM. Blood lines. Volume 3 of Issue 8. 2002. PMID: 12145653


  169. Stetson DB, Mohrs M, Mallet-Designe V, Teyton L, Locksley RM. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. 2002. PMID: 12196290


  170. Grogan JL, Locksley RM. T helper cell differentiation: on again, off again. 2002. PMID: 11973136


  172. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. 2002. PMID: 11970881


  173. Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Volume 15 of Issue 6. 2001. PMID: 11754813


  174. Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Volume 294 of Issue 5545. 2001. PMID: 11701932


  175. Mohrs M, Blankespoor CM, Wang ZE, Loots GG, Afzal V, Hadeiba H, Shinkai K, Rubin EM, Locksley RM. Deletion of a coordinate regulator of type 2 cytokine expression in mice. 2001. PMID: 11526400


  176. Mohrs M, Shinkai K, Mohrs K, Locksley RM. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. 2001. PMID: 11520464


  177. Bottrel RL, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Netto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Volume 69 of Issue 5. 2001. PMID: 11292745


  178. Maillard I, Launois P, Himmelrich H, Acha-Orbea H, Diggelmann H, Locksley RM, Louis JA. Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice. Volume 31 of Issue 4. 2001. PMID: 11298356


  179. Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Volume 14 of Issue 3. 2001. PMID: 11290331


  180. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Volume 104 of Issue 4. 2001. PMID: 11239407


  181. Locksley RM. Flying doctors. 2000. PMID: 11101861


  183. Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. Volume 165 of Issue 2. 2000. PMID: 10878366


  184. Hadeiba H, Corry DB, Locksley RM. Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system. Volume 164 of Issue 9. 2000. PMID: 10779804


  185. Lacy DA, Wang ZE, Symula DJ, McArthur CJ, Rubin EM, Frazer KA, Locksley RM. Faithful expression of the human 5q31 cytokine cluster in transgenic mice. Volume 164 of Issue 9. 2000. PMID: 10779759


  186. Himmelrich H, Launois P, Maillard I, Biedermann T, Tacchini-Cottier F, Locksley RM, Röcken M, Louis JA. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. Volume 164 of Issue 9. 2000. PMID: 10779790


  187. Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Volume 288 of Issue 5463. 2000. PMID: 10753117


  188. Shinkai K, Locksley RM. CD1, tuberculosis, and the evolution of major histocompatibility complex molecules. Volume 191 of Issue 6. 2000. PMID: 10727453


  189. Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). Volume 163 of Issue 12. 1999. PMID: 10586044


  190. Symula DJ, Frazer KA, Ueda Y, Denefle P, Stevens ME, Wang ZE, Locksley R, Rubin EM. Functional screening of an asthma QTL in YAC transgenic mice. Volume 23 of Issue 2. 1999. PMID: 10508526


  191. Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Volume 11 of Issue 4. 1999. PMID: 10549622


  192. Fowell DJ, Locksley RM. Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases. Volume 21 of Issue 6. 1999. PMID: 10402957


  193. Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM. Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope. Volume 189 of Issue 7. 1999. PMID: 10190902


  194. Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ. Susceptibility to infectious diseases: Leishmania as a paradigm. Volume 179 Suppl 2. 1999. PMID: 10081500


  195. Corry DB, Locksley RM. Construction of polycompetitors for competitive PCR. Volume 26. 1999. PMID: 21340883


  196. Bix M, Wang ZE, Thiel B, Schork NJ, Locksley RM. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. Volume 188 of Issue 12. 1998. PMID: 9858515


  197. Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Volume 282 of Issue 5397. 1998. PMID: 9856950


  198. Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM. Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. Volume 188 of Issue 9. 1998. PMID: 9802977


  199. Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM. Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model. Volume 9 of Issue 3 Suppl. 1998. PMID: 9831197


  200. Bix M, Locksley RM. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Volume 281 of Issue 5381. 1998. PMID: 9721100


  201. Joiner KA, Powderly WG, Blaser MJ, Klempner MS, Locksley RM, Mandell GL, Preheim LC, Remington JS, Slama TG, Steigbigel NH, Bartlett JG. Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors. 1998. PMID: 9597224


  202. Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Volume 4 of Issue 5. 1998. PMID: 9642684


  203. Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M. Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets. Volume 160 of Issue 8. 1998. PMID: 9558068


  204. Pingel S, Wang ZE, Locksley RM. Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major. Volume 66 of Issue 4. 1998. PMID: 9529117


  205. Brasch RC, Daldrup H, Shames D, Wendland M, Okuhata Y, Rosenau W. Macromolecular contrast media-enhanced MRI estimates of microvascular permeability correlate with histopathologic tumor grade. 1998. PMID: 9561030


  206. Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM. Control of Leishmania major by a monoclonal alpha beta T cell repertoire. Volume 160 of Issue 2. 1998. PMID: 9551925


  207. Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M. Development of CD4+ effector T cells and susceptibility to infectious diseases. Volume 452. 1998. PMID: 9889958


  208. McSorley SJ, Soldera S, Malherbe L, Carnaud C, Locksley RM, Flavell RA, Glaichenhaus N. Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells. Volume 7 of Issue 3. 1997. PMID: 9324360


  209. Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M. Altered immune responses in interleukin 10 transgenic mice. Volume 185 of Issue 12. 1997. PMID: 9182682


  210. Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Volume 6 of Issue 5. 1997. PMID: 9175832


  211. Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM. Impaired Th2 subset development in the absence of CD4. Volume 6 of Issue 5. 1997. PMID: 9175834


  212. Stevenson FT, Turck J, Locksley RM, Lovett DH. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein. 1997. PMID: 9012814


  213. Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL. T helper subset differentiation in the absence of invariant chain. Volume 185 of Issue 1. 1997. PMID: 8996239


  214. Locksley RM. Exploitation of immune and other defence mechanisms by parasites: an overview. Volume 115 Suppl. 1997. PMID: 9571686


  215. Wakil AE, Wang ZE, Locksley RM. Leishmania major: targeting IL-4 in successful immunomodulation of murine infection. Volume 84 of Issue 2. 1996. PMID: 8932771


  216. Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL. Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. Volume 184 of Issue 4. 1996. PMID: 8879201


  217. Corry DB, Ampel NM, Christian L, Locksley RM, Galgiani JN. Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis. Volume 174 of Issue 2. 1996. PMID: 8699085


  218. Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. Volume 184 of Issue 2. 1996. PMID: 8760807


  219. Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Volume 272 of Issue 5258. 1996. PMID: 8600536


  220. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. Volume 183 of Issue 1. 1996. PMID: 8551213


  221. Fowell DJ, Wakil AE, Locksley RM. Interleukin-12 in murine leishmaniasis--match, flame or fuel? Volume 146 of Issue 7-8. 1995. PMID: 8839163


  222. Bix M, Locksley RM. Natural T cells. Cells that co-express NKRP-1 and TCR. Volume 155 of Issue 3. 1995. PMID: 7636176


  223. Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N. Expression cloning of a protective Leishmania antigen. Volume 268 of Issue 5210. 1995. PMID: 7725103


  224. Locksley RM, Wakil AE, Corry DB, Pingel S, Bix M, Fowell DJ. The development of effector T cell subsets in murine Leishmania major infection. Volume 195. 1995. PMID: 8724833


  225. Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Volume 13. 1995. PMID: 7612219


  226. Wang ZE, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Volume 91 of Issue 26. 1994. PMID: 7809149


  227. Corry DB, Reiner SL, Linsley PS, Locksley RM. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. Volume 153 of Issue 9. 1994. PMID: 7523517


  228. Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46; 173(1994) 133). Volume 175 of Issue 2. 1994. PMID: 7930655


  229. Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46). Volume 173 of Issue 1. 1994. PMID: 8034981


  230. Locksley RM. Th2 cells: help for helminths. Volume 179 of Issue 5. 1994. PMID: 8163928


  231. Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. Volume 179 of Issue 4. 1994. PMID: 7908325


  233. Reiner SL, Locksley RM. Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis. Volume 53 of Issue 4. 1993. PMID: 7905485


  234. Holaday BJ, Pompeu MM, Jeronimo S, Texeira MJ, Sousa Ade A, Vasconcelos AW, Pearson RD, Abrams JS, Locksley RM. Potential role for interleukin-10 in the immunosuppression associated with kala azar. Volume 92 of Issue 6. 1993. PMID: 8254019


  235. Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR. Volume 165 of Issue 1. 1993. PMID: 8409467


  236. Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Volume 261 of Issue 5127. 1993. PMID: 8367726


  237. Azouaou N, Gelber RH, Abel K, Sasaki DT, Murray LP, Locksley RM, Mohagheghpour N. Reconstitution of Mycobacterium leprae immunity in severe combined immunodeficient mice using a T-cell line. Volume 61 of Issue 3. 1993. PMID: 8228438


  238. Wang ZE, Reiner SL, Hatam F, Heinzel FP, Bouvier J, Turck CW, Locksley RM. Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. Volume 151 of Issue 4. 1993. PMID: 8102158


  239. Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH. The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Volume 90 of Issue 15. 1993. PMID: 8346241


  240. Locksley RM. Interleukin 12 in host defense against microbial pathogens. Volume 90 of Issue 13. 1993. PMID: 8100997


  241. Reiner SL, Locksley RM. The worm and the protozoa: stereotyped responses or distinct antigens? Volume 9 of Issue 7. 1993. PMID: 15463773


  242. Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM. Transfected Leishmania expressing biologically active IFN-gamma. Volume 150 of Issue 11. 1993. PMID: 8098724


  243. Heinzel FP, Rerko RM, Hatam F, Locksley RM. IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. Volume 150 of Issue 9. 1993. PMID: 8473741


  244. Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM. TH1 and TH2 cell antigen receptors in experimental leishmaniasis. Volume 259 of Issue 5100. 1993. PMID: 8451641


  245. Stevenson FT, Bursten SL, Locksley RM, Lovett DH. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. Volume 176 of Issue 4. 1992. PMID: 1402651


  246. Locksley RM, Louis JA. Immunology of leishmaniasis. Volume 4 of Issue 4. 1992. PMID: 1356346


  247. Stevenson FT, Torrano F, Locksley RM, Lovett DH. Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms. Volume 152 of Issue 2. 1992. PMID: 1639857


  248. Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Volume 356 of Issue 6370. 1992. PMID: 1560843


  249. Reiner SL, Locksley RM. Lessons from Leishmania: a model for investigations of CD4+ subset differentiation. Volume 1 of Issue 1. 1992. PMID: 1365527


  250. Sadick MD, Street N, Mosmann TR, Locksley RM. Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice. Volume 59 of Issue 12. 1991. PMID: 1937832


  251. Holaday BJ, Sadick MD, Wang ZE, Reiner SL, Heinzel FP, Parslow TG, Locksley RM. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. Volume 147 of Issue 5. 1991. PMID: 1831830


  255. Gardner KD, Burnside JS, Elzinga LW, Locksley RM. Cytokines in fluids from polycystic kidneys. 1991. PMID: 2051729


  256. Locksley RM, Scott P. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Volume 12 of Issue 3. 1991. PMID: 1829891


  257. Locksley RM, Heinzel FP, Holaday BJ, Mutha SS, Reiner SL, Sadick MD. Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection. Volume 142 of Issue 1. 1991. PMID: 1829257


  258. Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. Volume 171 of Issue 1. 1990. PMID: 2104918


  259. Guglielmo BJ, Jacobs RA, Locksley RM. The exposure of health care workers to ribavirin aerosol. 1989. PMID: 2926922


  261. Locksley RM, Crowe S, Sadick MD, Heinzel FP, Gardner KD, McGrath MS, Mills J. Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo. Volume 82 of Issue 6. 1988. PMID: 3264291


  263. Hamadeh R, Ardehali A, Locksley RM, York MK. Fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient. Volume 94 of Issue 2. 1988. PMID: 3293934


  266. Locksley RM, Heinzel FP, Shepard HM, Agosti J, Eessalu TE, Aggarwal BB, Harlan JM. Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells. Volume 139 of Issue 6. 1987. PMID: 3497981


  267. Locksley RM, Heinzel FP, Sadick MD, Holaday BJ, Gardner KD. Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets. Volume 138 of Issue 5. 1987. PMID: 2964247


  268. Sadick MD, Heinzel FP, Shigekane VM, Fisher WL, Locksley RM. Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells. Volume 139 of Issue 4. 1987. PMID: 3112230


  270. Hickstein DD, Ozols J, Williams SA, Baenziger JU, Locksley RM, Roth GJ. Isolation and characterization of the receptor on human neutrophils that mediates cellular adherence. 1987. PMID: 3553180


  271. Hickstein DD, Smith A, Fisher W, Beatty PG, Schwartz BR, Harlan JM, Root RK, Locksley RM. Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells. 1987. PMID: 2947951


  272. Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK. Monoclonal antibodies binding to the human neutrophil C3bi receptor have disparate functional effects. 1986. PMID: 3006829


  274. Locksley RM, Flournoy N, Sullivan KM, Meyers JD. Infection with varicella-zoster virus after marrow transplantation. 1985. PMID: 3905982


  275. Locksley RM, Fankhauser J, Henderson WR. Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii. 1985. PMID: 2995993


  277. Jacobs RF, Locksley RM, Wilson CB, Haas JE, Klebanoff SJ. Interaction of primate alveolar macrophages and Legionella pneumophila. 1984. PMID: 6373825


  278. Ryser RJ, Locksley RM, Eng SC, Dobbins WO, Schoenknecht FD, Rubin CE. Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood-brain barrier. 1984. PMID: 6199255


  279. Locksley RM, Wilson CB, Klebanoff SJ. Increased respiratory burst in myeloperoxidase-deficient monocytes. 1983. PMID: 6309288


  280. Klebanoff SJ, Locksley RM, Jong EC, Rosen H. Oxidative response of phagocytes to parasite invasion. 1983. PMID: 6315321


  282. Locksley RM, Jacobs RF, Wilson CB, Weaver WM, Klebanoff SJ. Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems. 1982. PMID: 6288801


  283. Locksley RM, Cohen ML, Quinn TC, Tompkins LS, Coyle MB, Kirihara JM, Counts GW. Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection. 1982. PMID: 7114628


  284. Locksley RM, Wilson CB, Klebanoff SJ. Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes. Volume 69 of Issue 5. 1982. PMID: 7068848


  286. Moss AJ, DeCamilla J, Mietlowski W, Greene WA, Goldstein S, Locksley R. Prognostic grading and significance of ventricular premature beats after recovery from myocardial infarction. 1975. PMID: 52416


  287. Stam AC, Sole M, Locksley R, Weglicki WB, Sonnenblick EH. Two improvements in the preparation of cardiac microsomes. 1974. PMID: 4377613