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1001 Potrero Ave, Rm 3421 UCSF Box 0811 San Francisco, CA 94110

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Philip Rosenthal, MD

Professor

We have three main areas of interest, all involving malaria, one of the most important infections of humans. First, we study the basic biology of malaria parasites, including the biochemical properties and biological roles of parasite proteases and mechanisms of action of novel antimalarial agents. Second, in collaboration with industry and academic groups, we are pursuing drug discovery, evaluating protease inhibitors, oxaboroles, and other compounds as potential antimalarial drugs. Third, we study malaria in Africa, with translational and laboratory studies at UCSF and in Uganda and Burkina Faso evaluating antimalarial drug efficacy and resistance, the molecular epidemiology of malaria, the roles of host and parasite genetic polymorphisms in treatment outcomes, antimalarial pharmacokinetics and pharmacodynamics, and related areas. Finally, a new area of interest is using genetic tools to characterize causes of febrile illness in African children. In other activities, Dr. Rosenthal is Editor-in-Chief of the American Journal of Tropical Medicine and Hygiene; Chair, Scientific Advisory Committee, WorldWide Antimalarial Resistance Network; Member, Scientific Board, Infectious Diseases Data Observatory; and a member of the World Health Organization Technical Expert Group on Malaria Chemotherapy.
Education
Post-Doc Fellow/Scholar, 1988 - Medicine, University of California, San Francisco
Clinical Fellowship, - Infectious Diseases, University of California, San Francisco
Residency, - School of Medicine, University of Michigan
Publications
  1. He MS, He S, Roh M, Kakuru A, Jagannathan P, Dorsey G, Rosenthal P, Aweeka F, Huang L. Development and validation of UHPLC-MS/MS methods for determination of piperaquine in quantitative dried blood samples and microvolume plasma samples. 2026. PMID: 42090845


  2. Nankabirwa JI, Kakuru A, Nguyen AT, Roh ME, Aguti M, Adrama H, Kizza J, Olwoch P, Camanag K, Benjamin-Chung J, Rosenthal PJ, Kamya MR, Dorsey G, Jagannathan P. Impact of intermittent preventive treatment for malaria in pregnancy with sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine, and their combination on infant outcomes: A randomized controlled trial. 2026. PMID: 42007686


  3. Kancharla P, Dodean RA, Li Y, Zhang X, Kelly S, Charlton J, Binauhan AJ, Navarrete K, Garcia L, Mu J, Lu J, Caridha D, Madejczyk MS, Jin X, Dennis WE, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Chin GC, Chim-Ong A, Cui L, Qahash T, Shoue DA, Ferdig MT, Mockenhaupt FP, van Loon W, Ndoli JM, Kudyba H, Vega-Rodriguez J, Okitwi M, Kreutzfeld O, Docan C, Green C, Liu Y, Agulay A, Mirsalis J, Farrell SN, Probst AS, Nilsen A, Alday PH, Stone Doggett J, McFadden GI, Goodman CD, Catteruccia F, Rosenthal PJ, Riscoe MK, Cooper RA, Roth A, Kelly JX. Potent acridone antimalarial against all three life stages of Plasmodium. 2026. PMID: 41980931


  4. Aguti M, Nankabirwa JI, Kizza J, Kakuru A, Ssemukuye T, Adrama H, Olwoch P, Opira B, Odongo B, Camanag K, Nakalembe M, Clark T, Rosenthal PJ, Dorsey G, Jaganathan P, Kamya MR. Natural History and the Burden of Malaria During the First Year of Life in the High-Transmission Setting of Uganda. 2026. PMID: 41926926


  5. Diamond T, Chapin CA, Diorio CJ, McCuaig S, Lau M, Chu N, Gibson NM, Kreiger PA, Horslen S, Loomes KM, Banc-Husu AM, Chu J, Jensen MK, Leung DH, Narang A, Carter BA, Elisofon S, Fischer R, Lobritto SJ, Leonis M, Peters AL, Rodriguez-Baez N, Romero R, Rosenthal P, Rudnick D, Squires J, Sundaram S, Tolliver KM, Valentino P, Durkalski V, Alonso EM, Behrens EM. CD8 TRM-like T cells expressing perforin and IFN-γ define a pediatric activated T-cell acute liver failure endotype. 2026. PMID: 41921202


  6. Katairo T, Asua V, Semakuba FD, Nsengimaana B, Kiyaga S, Hathaway N, Murie K, Tukwasibwe S, Wiringilimaana I, Nakasaanya J, Mwubaha C, Achom KB, Esilu TE, Ayitewala A, Mbabazi M, Kabbale KD, Mulondo J, Watyekele E, Aranda-Diaz A, Maiteki CS, Opigo J, Dorsey G, Nsobya SL, Kamya MR, Agaba BB, Ssewanyana I, Greenhouse B, Rosenthal PJ, Briggs J, Conrad MD. Sustained High Prevalence of Multiple Antimalarial Drug Resistance Markers in Uganda in 2023-24. 2026. PMID: 41891011


  7. Kastenberg ZJ, Beil CA, Henn L, Alonso EM, Hsu EK, Wang K, Ng VL, Gupta NA, Magee JC, Merion RM, Horslen S, Karpen SJ, Kohli R, Loomes K, Miethke A, Tolliver KM, Rosenthal P, Harpavat S, Sokol RJ, Guthery SL, and the Childhood Liver Disease Research Network (ChiLDReN). Demographic Factors and Biliary Atresia: A Childhood Liver Disease Research Network Study. 2026. PMID: 41707679


  8. Pinheiro AS, Teixeira DE, Silva-Aguiar RP, Shim YJ, Merkulova AA, Silbak S, Skomorovska-Prokvolit Y, Midem D, Ogolla S, Burckhardt BB, Gangnus T, Scharfstein J, Caruso-Neves C, McCarty OJT, Gailani D, Bader M, Rosenthal PJ, Dent AE, Janse CJ, McCrae KR, Pinheiro AAS, Kazura JW, Schmaier AH. Bradykinin Contributes to Vasogenic Edema in Murine Experimental Cerebral Malaria. 2026. PMID: 42124709


  9. Kiyaga S, Mbabazi M, Katairo T, Kabbale KD, Asua V, Nsengimaana B, Wiringilimaana I, Semakuba FD, Mwubaha C, Nakasaanya J, Watyekele E, Ayitewala A, Tukwasibwe S, Mulondo J, Nsobya SL, Agaba B, Maiteki-Sebuguzi C, Kamya MR, Kateete DP, Nabende JN, Jjingo D, Mboowa G, Batte C, Ssewanyana I, Aranda-Díaz A, Dorsey G, Rosenthal PJ, Conrad M, Greenhouse B, Briggs J. Accuracy of Plasmodium falciparum genetic data for estimating parasite prevalence and malaria incidence in Uganda. 2026. PMID: 41723456


  10. Wadhwani SI, Spector PR, Feldman AG, Furuya KN, Hartjes K, Jarasvaraparn C, Kelly B, Lerret SM, Mysore K, Pawaria A, Rosenthal P, Shui A, Slowik V, Taylor S, Vittorio J, Valentino PL, Society of Pediatric Liver Transplantation (SPLIT). Defining the Society of Pediatric Liver Transplantation (SPLIT) research agenda: A Delphi consensus project. 2026. PMID: 41730231


  11. Kizza J, Katairo T, Kakuru A, Nsengimaana B, Esilu T, Wiringilimaana I, Semakuba FD, Gerlovina I, Hathaway N, Briggs J, Tukwasibwe S, Kiwuwa SM, Kamya MR, Nankabirwa JI, Dorsey G, Rosenthal PJ. Recurrent Plasmodium falciparum parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda. 2026. PMID: 41679334


  12. Adrama H, Dela Cruz EJ, Ozarslan N, Kakuru A, Odongo B, Gaw SL, Benjamin-Chung J, Kizza J, Aguti M, Ategeka J, Olwoch P, Nakalembe M, Opira B, Clark TD, Kamya MR, Rosenthal PJ, Dorsey G, Roh ME. Impact of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine on sexually transmitted and reproductive tract infections: results from a randomized trial in Uganda. 2026. PMID: 41657027


  13. Aguti M, Kizza J, Kakuru A, Nakalembe M, Nankabirwa JI, Gaw SL, Opira B, Ssemukuye T, Ozarslan N, Ranjit A, Dela Cruz E, Clark TD, Roh ME, Jagannathan P, Rosenthal PJ, Adrama H, Olwoch P, Mayende J, Odongo B, John A, Kamya M, Dorsey G. Maternal and household risk factors for malaria in pregnancy and low birthweight: a prospective cohort study from Uganda. 2025. PMID: 41469677


  14. Kiyaga S, Mbabazi M, Katairo T, Kabbale KD, Asua V, Nsengimaana B, Wiringilimaana I, Semakuba FD, Mwubaha C, Nakasaanya J, Watyekele E, Ayitewala A, Tukwasibwe S, Mulondo J, Nsobya SL, Agaba B, Maiteki-Sebuguzi C, Kamya MR, Kateete DP, Nabende JN, Jjingo D, Mboowa G, Batte C, Ssewanyana I, Aranda-Díaz A, Dorsey G, Rosenthal PJ, Conrad M, Greenhouse B, Briggs J. Accuracy of Plasmodium falciparum genetic data for estimating parasite prevalence and malaria incidence in Uganda. 2025. PMID: 41510267


  15. Kumar A, Li Y, Zhang X, Gaddam M, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Blount C, DeLuca J, Vuong C, Kudyba K, Roncal N, Ashraf K, Lee PJ, Pannone K, Leed S, Dinh HT, Mdaki K, Navarrete K, Charlton J, Binauhan AJ, Qahash T, Kibe KM, Shoue DA, Checkley L, Ferdig MT, Chim-Ong A, Cui L, Orena S, Byaruhanga O, Assimwe J, Tibagambirwa I, Chithanna S, Dodean RA, Legac J, Kreutzfeld O, Rosenthal PJ, Cooper RA, Reynolds KA, Roth A, Kelly JX, Kancharla P. Optimization of Prodiginines as Single-Dose Curative Antimalarials. 2025. PMID: 41253140


  16. Rosenthal PJ. Is Seasonal Malaria Chemoprevention with Sulfadoxine-Pyrimethamine/Amodiaquine Appropriate in East Africa? 2025. PMID: 41231735


  17. Kizza J, Katairo T, Kakuru A, Nsengimaana B, Esilu T, Wiringilimaana I, Semakuba FD, Gerlovina I, Hathaway N, Briggs J, Tukwasibwe S, Kiwuwa SM, Kamya MR, Nankabirwa JI, Dorsey G, Rosenthal PJ. Recurrent Plasmodium falciparum parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda. 2025. PMID: 41282777


  18. Haney RS, Butler JH, Wardlaw LA, Merino EF, Mendiola V, Cooper CA, Mathew J, Tumwebaze PK, Rosenthal PJ, Cooper RA, Kyle DE, Rizopoulos Z, Baud D, Brand S, Totrov M, Carlier PR, Cassera MB. Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant Plasmodium falciparum. 2025. PMID: 41105262


  19. Rosenthal PJ. Improving antimalarial therapeutic efficacy studies. 2025. PMID: 41043440


  20. Shneider BL, Kanchi RS, Grimm SL, Devaraj S, Emamaullee J, Schraw J, Lupo PJ, Bezerra JA, Loomes KM, Magee JC, Sokol RJ, Wang KS, Kriegmeier A, Hsu E, Molleston JP, Rosenthal P, Kohli R, Karpen SJ, Horslen SP, Jensen MK, Barbetta A, Coarfa C, Childhood Liver Disease Research Network. Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition. 2025. PMID: 41021277


  21. Kakuru A, Kizza J, Aguti M, Adrama H, Ategeka J, Olwoch P, Nakalembe M, Nankabirwa JI, Opira B, Ozarslan N, Ranjit A, Dela Cruz E, Clark TD, Roh ME, Gaw SL, Jagannathan P, Rosenthal PJ, Kamya MR, Dorsey G. Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda. 2025. PMID: 40966190


  22. Aguti M, Kizza J, Kakuru A, Nakalembe M, Nankabirwa JI, Gaw SL, Opira B, Ssemukuye T, Ozarslan N, Ranjit A, Cruz E, Clark TD, Roh ME, Jagannathan P, Rosenthal PJ, Adrama H, Olwoch P, Mayende J, Odongo B, John A, Kamya MR, Dorsey G. Maternal and household risk factors for malaria in pregnancy and low birthweight: a prospective cohort study from Uganda. 2025. PMID: 41001541


  23. Shneider BL, Goodrich NP, Ye W, Molleston JP, Leung DH, Sokol RJ, Cavallo L, Wang K, Valentino PL, Teckman JH, Squires JE, Sundaram SS, Rosenthal P, Romero R, Miethke AG, Loomes KM, Kohli R, Karpen SJ, Kamath BM, Jensen MK, Bezerra JA, Bass LM, Magee JC, ChiLDReN. Prospective Multicenter Longitudinal Measurement of Liver Stiffness in School-Age Children With Cholestatic Liver Disease. 2025. PMID: 41142527


  24. Lebel PM, Jeyakumar I, Khoo MWL, Emorut J, Charlton C, Saxena A, Jacobsen A, Huynh E, Wu W, Courville G, Fu PC, Raghavan M, Puccinelli R, Olwoch P, Dorsey G, Rosenthal PJ, DeRisi J, Gomez-Sjoberg R. Remoscope: a label-free imaging cytometer for malaria diagnostics. 2025. PMID: 40631413


  25. Kamya MR, Nankabirwa JI, Ebong C, Asua V, Kiggundu M, Orena S, Okitwi M, Tukwasibwe S, Agaba B, Kyabayinze D, Opigo J, Rutazana D, Binagwa B, Mugwanya E, Babirye S, Sebikaari G, Condo PM, Appiah G, Nsobya SL, Conrad MD, Rosenthal PJ, Moriarty LF, Yeka A. Efficacies of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine, and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in children aged 6 months to 10 years in Uganda: a randomised, open 2025. PMID: 40845863


  26. Maxwell SL, Price JC, Perito ER, Rosenthal P, Wojcicki JM. Weight gain in infancy and metabolic dysfunction-associated steatotic liver disease (MASLD) in a prospective birth cohort of Latino children. 2025. PMID: 40814062


  27. McClure M, Arinaitwe E, Kamya MR, Rosenthal PJ, Nankabirwa J, Kilama M, Musiime A, Dorsey G, Greenhouse B, Rodriguez-Barraquer I. Relating household entomological measures to individual malaria risk. 2025. PMID: 40804728


  28. Okitwi M, Orena S, Tumwebaze PK, Katairo T, Taremwa Y, Byaruhanga O, Tukwasibwe S, Nsobya SL, Legac J, Bailey JA, Cooper RA, Conrad MD, Rosenthal PJ. Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024. 2025. PMID: 40783405


  29. Klope MT, Talukder P, Blank BR, Chelebieva S, Chen J, Fontaine SD, Gonciarz RL, Jaishankar P, Lee GJ, Legac J, Mathur V, Narayan A, Okitwi M, Orena S, Settineri NS, Tapia JA, Taremwa Y, Tumwebaze PK, Vinod A, Burrows JN, Rosenthal PJ, Cooper RA, Renslo AR. Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance. 2025. PMID: 40779626


  30. Li J, Wang X, Lackner AI, Narasimhan P, Li L, Mallajosyula V, Johnson MM, Höbler AL, Kirosingh AS, Braun AE, Nankya F, Musinguzi K, Kakuru A, Kamya M, Rosenthal PJ, Dorsey G, Jagannathan P, Angelo M, Pollheimer J, Gaw SL, Winn VD, Nadeau KC, Davis MM. Regulatory KIR+CD8+ T cells are elevated during human pregnancy. 2025. PMID: 40768597


  31. Arzika AM, Abdou A, Maliki R, Lebas E, Cook C, Vanderschelden B, O'Brien KS, Cotter SY, Varnado NE, Callahan EK, Bailey RL, West SK, Rosenthal PJ, Porco TC, Lietman TM, Keenan JD, MORDOR-Niger Study Group. Biannual Mass Azithromycin Distributions for Preschool Children and Malaria Parasitemia: A Secondary Analysis of the MORDOR Cluster Randomized Trial. 2025. PMID: 40824641


  32. Nardella F, Jiang T, Wang L, Bohmer MJ, Chakraborty S, Okombo J, Calla J, Silva TM, Pazicky S, Che J, Jeon J, Vincent E, Boonyalai N, Coyle R, Buchanan MJ, Schaefer S, Chen D, Khan A, Mayville E, De Souza ML, Treat M, Charlton J, Tumwebaze PK, Tjia S, Montejo L, Cover K, Rosenthal PJ, Cooper RA, Bozdech Z, Lee MCS, Chakrabarti R, Desai SA, Fidock DA, Wang J, Gray NS, Winzeler EA, Chakrabarti D. Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity. 2025. PMID: 40628257


  33. Adrama H, Dela Cruz EJ, Ozarslan N, Kakuru A, Odongo B, Gaw SL, Benjamin-Chung J, Kizza J, Aguti M, Ategeka J, Olwoch P, Nakalembe M, Opira B, Clark TD, Kamya MR, Rosenthal PJ, Dorsey G, Roh ME. Impact of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine on sexually transmitted and reproductive tract infections: results from a randomised trial in Uganda. 2025. PMID: 40630588


  34. Kancharla P, Dodean RA, Li Y, Zhang X, Kelly S, Charlton J, Binauhan A, Garcia L, Caridha D, Madejczyk MS, Jin X, Dennis WE, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Chimong A, Cui L, Vega-Rodriguez J, Okitwi M, Kreutzfeld O, Docan C, Green C, Liu Y, Agulay A, Mirsalis J, Farrell SN, McFadden GI, Goodman CD, Probst AS, Nilsen A, Catteruccia F, Rosenthal PJ, Riscoe M, Cooper R, Roth A, Kelly J. Potent Acridone Antimalarial against All Three Life Stages of Plasmodium. 2025. PMID: 40678217


  35. Niaré K, Crudale R, Fola AA, Wernsman Young N, Asua V, Conrad MD, Gashema P, Ghansah A, Hangi S, Ishengoma DS, Mazarati JB, Zeleke AJ, Rosenthal PJ, Djimdé AA, Juliano JJ, Bailey JA. Highly multiplexed molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole-genome sequencing assessments for selection and relatedness. 2025. PMID: 40574802


  36. Katairo T, Asua V, Nsengimaana B, Tukwasibwe S, Semakuba FD, Wiringilimaana I, Kagurusi BA, Mwubaha C, Nakasaanya J, Garg S, Kiyaga S, Mbabazi M, Kabbale KD, Ayitewala A, Nsobya SL, Kamya MR, Ssewanyana I, Bailey JA, Aranda-Díaz A, Rosenthal PJ, Greenhouse B, Briggs J, Conrad MD. Performance of molecular inversion probe DR23K and Paragon MAD4HatTeR Amplicon sequencing panels for detection of Plasmodium falciparum mutations associated with antimalarial drug resistance. 2025. PMID: 40506703


  37. Kumar A, Li Y, Zhang X, Jin X, Dennis WE, Chetree R, Blount C, Caridha D, Madejczyk MS, Lee PJ, Pannone K, DeLuca J, Vuong C, Leed S, Dinh HT, Mdaki K, Mahato R, Sen P, Mondal T, Phukan K, Saha A, Chim-Ong A, Cui L, Valmon R, Chithanna S, Dodean RA, Peyton DH, Orena S, Assimwe J, Tibagambirwa I, Angutoko P, Legac J, Kreutzfeld O, Rosenthal PJ, Chenu E, Duffy J, Roth A, Reynolds KA, Kelly JX, Kancharla P. Optimization of Tambjamines Active against Multiple Stages of Malaria Parasites. 2025. PMID: 40450579


  38. Nguyen TD, Zupko RJ, Conrad MD, Rukundo GB, Farinha CC, Asua VD, Tran KT, Grace DM, Rosenthal PJ, Agaba BB, Kamya MR, Opigo J, Boni MF. Slowing the spread of treatment failure to artemisinin-based combination therapies in Uganda. 2025. PMID: 40463542


  39. Dodean RA, Li Y, Zhang X, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Pou S, Winter RW, Liebman KM, Williams R, Kumar A, Chim-Ong A, Cui L, Orena S, Assimwe J, Tibagambirwa I, Byaruhanga O, Angutoko P, Legac J, Kreutzfeld O, Rosenthal PJ, Cooper RA, Nilsen A, Riscoe MK, Roth A, Kancharla P, Kelly JX. Development of Next-Generation Antimalarial Acridones with Radical Cure Potential. 2025. PMID: 40179277


  40. Gonzalez-Peralta RP, Wen JW, Hardikar W, Karnsakul WW, Whitworth S, Lin CH, Indolfi G, Rosenthal P, Balistreri W, Schwarz KB, Honegger JR, Zhang X, Svarovskaia EC, Suri V, Kersey K, Leung DH. Long-term efficacy and safety of sofosbuvir-based direct-acting antiviral regimens in paediatric patients with hepatitis C virus infection: an international registry study. 2025. PMID: 40113366


  41. Meier-Scherling CPG, Watson OJ, Asua V, Ghinai I, Katairo T, Garg S, Conrad MD, Rosenthal PJ, Okell LC, Bailey JA. Selection of Plasmodium falciparum kelch13 mutations in Uganda in comparison with southeast Asia: a modelling study. 2025. PMID: 40112841


  42. Niaré K, Crudale R, Fola AA, Wernsman Young N, Asua V, Conrad M, Gashema P, Ghansah A, Hangi S, Ishengoma DS, Mazarati JB, Zeleke AJ, Rosenthal PJ, Djimdé AA, Juliano JJ, Bailey JA. Highly multiplex molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole genome sequencing assessments for selection and relatedness. 2025. PMID: 40162260


  43. Rosenthal PJ, Hamer DH, Bausch DG, Nishi JB, Fidock DA. US Public Health and Biomedical Research Institutions Help Keep the World Safe and Deserve Continued Strong Support. 2025. PMID: 40080909


  44. Ozarslan N, Mong C, Ategeka J, Li L, Buarpung S, Robinson JF, Kizza J, Kakuru A, Kamya MR, Dorsey G, Rosenthal PJ, Gaw SL. Placental malaria induces a unique methylation profile associated with fetal growth restriction. 2025. PMID: 40051167


  45. McClure M, Arinaitwe E, Kamya MR, Rosenthal PJ, Nankabirwa J, Maxwell K, Musiime A, Dorsey G, Greenhouse B, Rodriguez-Barraquer I. Relating household entomological measures to individual malaria risk. 2025. PMID: 39975909


  46. Taylor SA, Harpavat S, Gromer KD, Andreev V, Loomes KM, Bezerra JA, Jarasvaraparn C, Wang K, Horslen S, Rosenthal P, Teckman J, Valentino PL, Ng VL, Karpen SJ, Sokol RJ, Alonso EM, Mack CL, Childhood Liver Disease Research Network (ChiLDReN). Increased serum GM-CSF at diagnosis of biliary atresia is associated with improved biliary drainage. 2025. PMID: 39881181


  47. Katairo T, Asua V, Nsengimaana B, Tukwasibwe S, Semakuba FD, Wiringilimaana I, Garg S, Kiyaga S, Mbabazi M, Kabbale KD, Ayitewala A, Nsobya SL, Kamya MR, Ssewanyana I, Bailey JA, Aranda-Díaz A, Rosenthal PJ, Greenhouse B, Briggs J, Conrad MD. Performance of Molecular Inversion Probe DR23K and Paragon MAD4HatTeR Amplicon Sequencing Panels for Detection of Plasmodium falciparum Mutations Associated with Antimalarial Drug Resistance. 2025. PMID: 39975885


  48. Rosenthal PJ. Artemisinin Partial Resistance and the Treatment of Severe Malaria. 2024. PMID: 39540803


  49. Okitwi M, Orena S, Tumwebaze PK, Katairo T, Taremwa Y, Byaruhanga O, Tukwasibwe S, Nsobya SL, Legac J, Cooper RA, Conrad MD, Rosenthal PJ. Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024. 2025. PMID: 39802777


  50. Martinez-Vega R, Ishengoma DS, Gosling R, Rosenthal PJ, Dondorp A, Barnes KI, Nsanzabana C, Djimde AA, Ochola-Oyier LI, Tibenderana J, Chimumbwa J, Golassa L, Kapologwe NA, Mbacham WF, Kamya MR, Fidock DA, Komatsu R, von Seidlein L, Dhorda M. Regional action needed to halt antimalarial drug resistance in Africa. 2024. PMID: 39674185


  51. Gomez-Gonzalez PJ, Gupta A, Drought LG, Patel A, Okombo J, van der Watt M, Walker-Gray R, Schindler KA, Burkhard AY, Yeo T, Narwal SK, Bloxham TS, Flueck C, Walker EM, Rey JA, Fairhurst KJ, Reader J, Park H, Pollard HG, Stewart LB, Brandner-Garrod L, Kristan M, Sterk GJ, van Nuland YM, Manko E, van Schalkwyk DA, Zheng Y, Leurs R, Dechering KJ, Aguiar ACC, Guido RVC, Pereira DB, Tumwebaze PK, Nosbya SL, Rosenthal PJ, Cooper RA, Palmer M, Parkinson T, Burrows JN, Uhlemann AC, Birkholtz LM, Small-Saunders JL, Duffy J, Fidock DA, Brown A, Gardner M, Baker DA. Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. 2024. PMID: 39642214


  52. Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK, Economy JM, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, Melillo B, Mok S, Narwal SK, Ndiaye T, Ottilie S, Palomo Diaz S, Park H, Peña S, Rocamora F, Sakata-Kato T, Small-Saunders JL, Summers RL, Tumwebaze PK, Vanaerschot M, Xia G, Yeo T, You A, Gamo FJ, Goldberg DE, Lee MCS, McNamara CW, Ndiaye D, Rosenthal PJ, Schreiber SL, Serra G, De Siqueira-Neto JL, Skinner-Adams TS, Uhlemann AC, Kato N, Lukens AK, Wirth DF, Fidock DA, Winzeler EA. Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. 2024. PMID: 39607932


  53. Okitwi M, Shoue DA, Checkley LA, Orena S, Ceja FG, Taremwa Y, Tumwebaze PK, Katairo T, Byaruhanga O, Sievert MA, Garg S, Kreutzfeld OK, Legac J, Bailey JA, Nsobya SL, Conrad MD, Rosenthal PJ, Ferdig MT, Cooper RA. The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates. 2024. PMID: 39545737


  54. Lebel PM, Jeyakumar I, Khoo MWL, Charlton C, Saxena A, Jacobsen A, James E, Huynh E, Wu W, Courville G, Fu PC, Raghavan M, Puccinelli R, Peter O, Dorsey G, Rosenthal P, DeRisi J, Gomez-Sjoberg R. Remoscope: a label-free imaging cytometer for malaria diagnostics. 2024. PMID: 39606416


  55. Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S, Winzeler EA, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P. Tambjamines as Fast-Acting Multistage Antimalarials. 2024. PMID: 39526703


  56. Rosenthal PJ. Refugees. 2024. PMID: 39499950


  57. Tukwasibwe S, Lewis SN, Taremwa Y, van der Ploeg K, Press KD, Ty M, Namirimu Nankya F, Musinguzi K, Nansubuga E, Bach F, Chamai M, Okitwi M, Tumusiime G, Nakimuli A, Colucci F, Kamya MR, Nankabirwa JI, Arinaitwe E, Greenhouse B, Dorsey G, Rosenthal PJ, Ssewanyana I, Jagannathan P. Natural killer cell antibody-dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission. 2024. PMID: 39493859


  58. Zumla A, Rosenthal PJ, Sam-Agudu NA, Ogoina D, Mbala-Kingebeni P, Ntoumi F, Nakouné E, Njouom R, Ndembi N, Mills EJ, Muyembe-Tamfum JJ, Nachega JB. The 2024 Public Health Emergency of International Concern: A Global Failure to Control Mpox. 2024. PMID: 39406210


  59. Mwebaza N, Roh ME, Geng YZ, Opio L, Opira B, Marzan F, Mwima MW, Ssemukuye T, Guo K, Gingrich D, Fotaki N, Kakuru A, Kizza J, Aguti M, Adrama H, Kamya M, Dorsey G, Rosenthal PJ, Aweeka FT, Huang L. Drug-Drug Interaction Between Dihydroartemisinin-Piperaquine and Sulfadoxine-Pyrimethamine During Malaria Chemoprevention in Pregnant Women. 2024. PMID: 39402742


  60. Ozarslan N, Mong C, Ategeka J, Li L, Buarpung S, Robinson JF, Kizza J, Kakuru A, Kamya MR, Dorsey G, Rosenthal PJ, Gaw SL. Placental Malaria Induces a Unique Placental Methylation Profile Associated with Fetal Growth Restriction. 2024. PMID: 38798500


  61. Jacobson KB, Röltgen K, Lam B, Nayebare P, Kakuru A, Kizza J, Aguti M, Nankya F, Briggs J, Takahashi S, Greenhouse B, Rodriguez-Barraquer I, van der Ploeg K, Wohlstadter JN, Sigal GB, Roh ME, Nankabirwa JI, Cuu G, Gaw SL, Rosenthal PJ, Kamya MR, Ssewanyana I, Dorsey G, Boyd SD, Jagannathan P. Gestational SARS-CoV-2 Infection in a Ugandan Birth Cohort: High Incidence, Mild Maternal Disease, and Evidence of Association with Transient Infant Stunting. 2024. PMID: 39288758


  62. Jain AK, Busgang SA, Gennings C, Yates KP, Schwimmer JB, Rosenthal P, Murray KF, Molleston JP, Scheimann A, Xanthakos SA, Behling CA, Carpenter D, Fishbein M, Neuschwander-Tetri BA, Tonasia J, Vos MB. Environmental toxicants modulate disease severity in pediatric metabolic dysfunction-associated steatohepatitis. 2024. PMID: 39282813


  63. Klope MT, Tapia Cardona JA, Chen J, Gonciarz RL, Cheng K, Jaishankar P, Kim J, Legac J, Rosenthal PJ, Renslo AR. Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains. 2024. PMID: 39411530


  64. Kamya MR, Nankabirwa JI, Arinaitwe E, Rek J, Zedi M, Maiteki-Sebuguzi C, Opigo J, Staedke SG, Oruni A, Donnelly MJ, Greenhouse B, Briggs J, Krezanoski PJ, Bousema T, Rosenthal PJ, Olwoch P, Jagannathan P, Rodriguez-Barraquer I, Dorsey G. Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda. 2024. PMID: 39208072


  65. Tukwasibwe S, Garg S, Katairo T, Asua V, Kagurusi BA, Mboowa G, Crudale R, Tumusiime G, Businge J, Alula D, Kasozi J, Wadembere I, Ssewanyana I, Arinaitwe E, Nankabirwa JI, Nsobya SL, Kamya MR, Greenhouse B, Dorsey G, Bailey JA, Briggs J, Conrad MD, Rosenthal PJ. Varied prevalence of antimalarial drug resistance markers in different populations of newly arrived refugees in Uganda. 2024. PMID: 38874098


  66. Kreutzfeld O, Orena S, Okitwi M, Tumwebaze PK, Byaruhanga O, Katairo T, Conrad MD, Legac J, Garg S, Crudale R, Aydemir O, Giesbrecht D, Nsobya SL, Blasco B, Duffey M, Rouillier M, Bailey JA, Cooper RA, Rosenthal PJ. Ex vivo susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan Plasmodium falciparum isolates. 2024. PMID: 39136468


  67. Dhorda M, Kaneko A, Komatsu R, Kc A, Mshamu S, Gesase S, Kapologwe N, Assefa A, Opigo J, Adoke Y, Ebong C, Karema C, Uwimana A, Mangara JN, Amaratunga C, Peto TJ, Tripura R, Callery JJ, Adhikari B, Mukaka M, Cheah PY, Mutesa L, Day NPJ, Barnes KI, Dondorp A, Rosenthal PJ, White NJ, von Seidlein L. Artemisinin-resistant malaria in Africa demands urgent action. 2024. PMID: 39024426


  68. Ishengoma DS, Gosling R, Martinez-Vega R, Beshir KB, Bailey JA, Chimumbwa J, Sutherland C, Conrad MD, Tadesse FG, Juliano JJ, Kamya MR, Mbacham WF, Ménard D, Rosenthal PJ, Raman J, Tatarsky A, Tessema SK, Fidock DA, Djimde AA. Urgent action is needed to confront artemisinin partial resistance in African malaria parasites. 2024. PMID: 38710833


  69. Ozarslan N, Robinson JF, Buarpung S, Kim MY, Ansbro MR, Akram J, Montoya DJ, Kamya MR, Kakuru A, Dorsey G, Rosenthal PJ, Cheng G, Feeney ME, Fisher SJ, Gaw SL. Gravidity influences distinct transcriptional profiles of maternal and fetal placental macrophages at term. 2024. PMID: 38994356


  70. Rosenthal PJ, Asua V, Conrad MD. Author Correction: Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa. 2024. PMID: 38413816


  71. Nachega JB, Sam-Agudu NA, Ogoina D, Mbala-Kingebeni P, Ntoumi F, Nakouné E, Njouom R, Lewis RF, Gandhi M, Rosenthal PJ, Rawat A, Wilson LA, Kindrachuk J, Liesenborghs L, Mills EJ, Preiser W, Rimoin AW, Sullivan NJ, Peeters M, Delaporte E, Baxter C, Harrison L, Hermans MP, Mohr EL, Gonsalves G, Ndembi N, Zumla A, Muyembe-Tamfum JJ, Mpox Research Consortium. The surge of mpox in Africa: a call for action. 2024. PMID: 38735300


  72. Ovchinsky N, Aumar M, Baker A, Baumann U, Bufler P, Cananzi M, Czubkowski P, Durmaz Ö, Fischer R, Indolfi G, Karnsakul WW, Lacaille F, Lee WS, Maggiore G, Rosenthal P, Ruiz M, Sokal E, Sturm E, van der Woerd W, Verkade HJ, Wehrman A, Clemson C, Yu Q, Ni Q, Ruvido J, Manganaro S, Mattsson JP. Efficacy and safety of odevixibat in patients with Alagille syndrome (ASSERT): a phase 3, double-blind, randomised, placebo-controlled trial. 2024. PMID: 38670135


  73. Jonas MM, Romero R, Rosenthal P, Lin CH, Verucchi G, Wen J, Balistreri WF, Whitworth S, Bansal S, Leung DH, Narkewicz MR, Gonzalez-Peralta RP, Mangia A, Karnsakul W, Rao GS, Shao J, de Jong J, Parhy B, Osinusi A, Kersey K, Murray KF, Sokal EM, Schwarz KB. Sofosbuvir-velpatasvir in children 3-17 years old with hepatitis C virus infection. 2024. PMID: 38644678


  74. Di Chio C, Starvaggi J, Totaro N, Previti S, Natale B, Cosconati S, Bogacz M, Schirmeister T, Legac J, Rosenthal PJ, Zappalà M, Ettari R. Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria. 2024. PMID: 38673995


  75. Rosenthal PJ, Asua V, Bailey JA, Conrad MD, Ishengoma DS, Kamya MR, Rasmussen C, Tadesse FG, Uwimana A, Fidock DA. The emergence of artemisinin partial resistance in Africa: how do we respond? 2024. PMID: 38552654


  76. Kamya MR, Nankabirwa JI, Arinaitwe E, Rek J, Zedi M, Maiteki-Sebuguzi C, Opigo J, Staedke SG, Oruni A, Donnelly MJ, Greenhouse B, Briggs J, Krezanoski PJ, Bousema T, Rosenthal PJ, Olwoch P, Jagannathan P, Rodriguez-Barraquer I, Dorsey G. Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda. 2024. PMID: 38559091


  77. Maxwell SL, Price JC, Perito ER, Rosenthal P, Wojcicki JM. Food insecurity is a risk factor for metabolic dysfunction-associated steatotic liver disease in Latinx children. 2024. PMID: 38453472


  78. Pandurangi S, Mourya R, Nalluri S, Fei L, Dong S, Harpavat S, Guthery SL, Molleston JP, Rosenthal P, Sokol RJ, Wang KS, Ng V, Alonso EM, Hsu EK, Karpen SJ, Loomes KM, Magee JC, Shneider BL, Horslen SP, Teckman JH, Bezerra JA, and the Childhood Liver Disease Research Network. Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort. 2024. PMID: 38446707


  79. Somé AF, Conrad MD, Kabré Z, Fofana A, Yerbanga RS, Bazié T, Neya C, Somé M, Kagambega TJ, Legac J, Garg S, Bailey JA, Ouédraogo J-B, Rosenthal PJ, Cooper RA. Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso. 2024. PMID: 38411062


  80. Himes R, Rosenthal P, Dilwali N, Smith K, Venick R, Gonzalez-Peralta RP. Real-world experience of maralixibat in Alagille syndrome: Novel findings outside of clinical trials. 2024. PMID: 38334237


  81. Rosenthal PJ, Asua V, Conrad MD. Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa. 2024. PMID: 38321292


  82. Meier-Scherling CPG, Watson OJ, Asua V, Ghinai I, Katairo T, Garg S, Conrad M, Rosenthal PJ, Okell LC, Bailey JA. Selection of artemisinin partial resistance Kelch13 mutations in Uganda in 2016-22 was at a rate comparable to that seen previously in South-East Asia. 2024. PMID: 38352505


  83. Sok V, Marzan F, Roh M, Guo K, Legac J, Mwebaza N, Dorsey G, Rosenthal PJ, Aweeka FT, Huang L. Determination of sulfadoxine and pyrimethamine in microvolume human plasma using ultra high performance liquid chromatography-tandam mass spectrometry. 2024. PMID: 38309043


  84. Wang L, Bohmer MJ, Wang J, Nardella F, Calla J, Laureano De Souza M, Schindler KA, Montejo L, Mittal N, Rocamora F, Treat M, Charlton JT, Tumwebaze PK, Rosenthal PJ, Cooper RA, Chakrabarti R, Winzeler EA, Chakrabarti D, Gray NS. Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. 2024. PMID: 38214254


  85. Van Hove JLK, Friederich MW, Strode DK, Van Hove RA, Miller KR, Sharma R, Shah H, Estrella J, Gabel L, Horslen S, Kohli R, Lovell MA, Miethke AG, Molleston JP, Romero R, Squires JE, Alonso EM, Guthery SL, Kamath BM, Loomes KM, Rosenthal P, Mysore KR, Cavallo LA, Valentino PL, Magee JC, Sundaram SS, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Protein biomarkers GDF15 and FGF21 to differentiate mitochondrial hepatopathies from other pediatric liver diseases. 2024. PMID: 38180987


  86. Cheng K, Rosenthal P. Diagnosis and management of Alagille and progressive familial intrahepatic cholestasis. 2023. PMID: 38055640


  87. Teckman J, Rosenthal P, Ignacio RV, Spino C, Bass LM, Horslen S, Wang K, Magee JC, Karpen S, Asai A, Molleston JP, Squires RH, Kamath BM, Guthery SL, Loomes KM, Shneider BL, Sokol RJ, ChiLDReN (Childhood Liver Disease Research Network). Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance. 2023. PMID: 38055647


  88. Jain AK, Buchannan P, Yates KP, Belt P, Schwimmer JB, Rosenthal P, Murray KF, Molleston JP, Scheimann A, Xanthakos SA, Behling CA, Hertel P, Nilson J, Neuschwander-Tetri BA, Tonascia J, Vos MB, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Nutrition assessment and MASH severity in children using the Healthy Eating Index. 2023. PMID: 38055641


  89. Pal K, Lala S, Agarwal P, Patel TS, Legac J, Rahman MA, Ahmedi S, Shahid N, Singh S, Kumari K, Madhav H, Sen A, Manzoor N, Dixit BC, Van Zyl R, Rosenthal PJ, Hoda N. Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: in silico, synthesis, and biological approach. 2023. PMID: 38107179


  90. Boster JM, Goodrich NP, Spino C, Loomes KM, Alonso EM, Kamath BM, Sokol RJ, Karpen S, Miethke A, Shneider BL, Molleston JP, Kohli R, Horslen SP, Rosenthal P, Valentino PL, Teckman JH, Hangartner TN, Sundaram SS, Childhood Liver Disease Research Network (ChiLDReN). Sarcopenia is associated with osteopenia and impaired quality of life in children with genetic intrahepatic cholestatic liver disease. 2023. PMID: 37902507


  91. Roh ME, Zongo I, Haro A, Huang L, Somé AF, Yerbanga RS, Conrad MD, Wallender E, Legac J, Aweeka F, Ouédraogo JB, Rosenthal PJ. Seasonal malaria chemoprevention drug levels and drug resistance markers in children with or without malaria in Burkina Faso: a case control study. 2023. PMID: 37221018


  92. Ozarslan N, Robinson JF, Buarpung S, Kim MY, Ansbro MR, Akram J, Montoya DJ, Kamya MR, Kakuru A, Dorsey G, Rosenthal PJ, Cheng G, Feeney ME, Fisher SJ, Gaw SL. Distinct transcriptional profiles of maternal and fetal placental macrophages at term are associated with gravidity. 2023. PMID: 37808856


  93. Schwarzenberg SJ, King WC, Ling SC, Murray KF, Mogul D, Rosenthal P, Rodriguez-Baez N, Teckman J, Schwarz KB, Hepatitis B Research Network (HBRN). Change in Health-Related Quality of Life in Youth with Chronic Hepatitis B Living in North America: A 5-Year Cohort Study. 2023. PMID: 37756340


  94. Kirosingh AS, Delmastro A, Kakuru A, van der Ploeg K, Bhattacharya S, Press KD, Ty M, Parte L, Kizza J, Muhindo M, Devachanne S, Gamain B, Nankya F, Musinguzi K, Rosenthal PJ, Feeney ME, Kamya M, Dorsey G, Jagannathan P. Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria. 2023. PMID: 37634385


  95. Conrad MD, Asua V, Garg S, Giesbrecht D, Niaré K, Smith S, Namuganga JF, Katairo T, Legac J, Crudale RM, Tumwebaze PK, Nsobya SL, Cooper RA, Kamya MR, Dorsey G, Bailey JA, Rosenthal PJ. Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda. 2023. PMID: 37611122


  96. Nachega JB, Mbala-Kingebeni P, Rosenthal PJ, Rimoin AW, Hoff NA, Liesenborghs L, Vanlerberghe V, Andrei G, Rawat A, Wilson LA, Forrest J, Mills EJ, Hermans MP, Mulangu S, Ntoumi F, Zumla A, Muyembe-Tamfum JJ. The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries. 2023. PMID: 37580027


  97. Rosenthal PJ. Proteasome inhibitors: The next generation of antimalarial drugs? 2023. PMID: 37207628


  98. Squires JE, Miethke AG, Valencia CA, Hawthorne K, Henn L, Van Hove JLK, Squires RH, Bove K, Horslen S, Kohli R, Molleston JP, Romero R, Alonso EM, Bezerra JA, Guthery SL, Hsu E, Karpen SJ, Loomes KM, Ng VL, Rosenthal P, Mysore K, Wang KS, Friederich MW, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children. 2023. PMID: 37184518


  99. Ghany MG, Belle SH, Kleiner DE, Smith C, Kelley SS, Rosenthal P, Fontana RJ, Hepatitis B Research Network. Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study. 2023. PMID: 37184524


  100. Kreutzfeld O, Tumwebaze PK, Okitwi M, Orena S, Byaruhanga O, Katairo T, Conrad MD, Rasmussen SA, Legac J, Aydemir O, Giesbrecht D, Forte B, Campbell P, Smith A, Kano H, Nsobya SL, Blasco B, Duffey M, Bailey JA, Cooper RA, Rosenthal PJ. Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline. 2023. PMID: 37158739


  101. Previti S, Ettari R, Di Chio C, Legac J, Bogacz M, Zimmer C, Schirmeister T, Rosenthal PJ, Zappalà M. Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis. 2023. PMID: 37163812


  102. Blank BR, Gut J, Rosenthal PJ, Renslo AR. Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials. 2023. PMID: 37077383


  103. Wojcicki JM, Gill RM, Wilson L, Lin J, Rosenthal P. Shorter leukocyte telomere length protects against NAFLD progression in children. 2023. PMID: 37012261


  104. Hong H, Aslam-Mir U, Kajubi R, Wallender E, Mwebaza N, Dorsey G, Rosenthal PJ, Aweeka FT, Huang L. Efavirenz-Based Antiretroviral Therapy but Not Pregnancy Increased Unbound Piperaquine Exposure in Women during Malaria Chemoprevention. 2023. PMID: 36916944


  105. Harpavat S, Hawthorne K, Setchell KDR, Rivas MN, Henn L, Beil CA, Karpen SJ, Ng VL, Alonso EM, Bezerra JA, Guthery SL, Horslen S, Loomes KM, McKiernan P, Magee JC, Merion RM, Molleston JP, Rosenthal P, Thompson RJ, Wang KS, Sokol RJ, Shneider BL, for Childhood Liver Disease Research Network (ChiLDReN). Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy. 2023. PMID: 36131538


  106. Gonzalez-Peralta RP, Wirth S, Squires RH, Mutschler F, Lang T, Pawlowska M, Sluzewski W, Majda-Stanislawska E, Fischler B, Balistreri WF, Jonas MM, Blondet N, Rosenthal P, Alkhouri N, Romero R, Grandhi A, Castronuovo P, Caro L, Du L, Rosenbloom DIS, Haber BA. Elbasvir/grazoprevir in children aged 3-18 years with chronic HCV genotype 1 or 4 infection: a pharmacokinetic modeling study. 2023. PMID: 36790337


  107. Miloh T, Goldstein A, Howard R, Mogul DB, Marden JR, Anderson A, Gaburo K, Kirson N, Rosenthal P. Costs of pediatric liver transplantation among commercially insured and Medicaid-insured patients with cholestasis in the US. 2023. PMID: 36747344


  108. Briggs J, Takahashi S, Nayebare P, Cuu G, Rek J, Zedi M, Kizza T, Arinaitwe E, Nankabirwa JI, Kamya M, Jagannathan P, Jacobson K, Rosenthal PJ, Dorsey G, Greenhouse B, Ssewanyana I, Rodr?guez-Barraquer I. Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022. 2023. PMID: 36790811


  109. Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Michino M, Yukawa T, Chelebieva S, Tumwebaze PK, Vendome J, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, Liverton N, Foley M, Meinke PT, Nathan CF, Kirkman LA, Lin G. Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors-Part II. 2023. PMID: 36630286


  110. Nankabirwa JI, Bousema T, Blanken SL, Rek J, Arinaitwe E, Greenhouse B, Rosenthal PJ, Kamya MR, Staedke SG, Dorsey G. Measures of malaria transmission, infection, and disease in an area bordering two districts with and without sustained indoor residual spraying of insecticide in Uganda. 2022. PMID: 36584122


  111. Pal K, Raza MK, Legac J, Rahman A, Manzoor S, Bhattacharjee S, Rosenthal PJ, Hoda N. Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents. 2022. PMID: 36621136


  112. Nachega JB, Nsanzimana S, Rawat A, Wilson LA, Rosenthal PJ, Siedner MJ, Varma JK, Kilmarx PH, Mutesa L, Tanner M, Binagwaho A, Forrest J, Mbala-Kingebeni P, Muyembe-Tamfum JJ, Ntoumi F, Zumla A, de Oliveira T, Mills EJ. Advancing detection and response capacities for emerging and re-emerging pathogens in Africa. 2022. PMID: 36563700


  113. Mawejje HD, Asiimwe JR, Kyagamba P, Kamya MR, Rosenthal PJ, Lines J, Dorsey G, Staedke SG. Impact of different mosquito collection methods on indicators of Anopheles malaria vectors in Uganda. 2022. PMID: 36536428


  114. Mawejje HD, Weetman D, Epstein A, Lynd A, Opigo J, Maiteki-Sebuguzi C, Lines J, Kamya MR, Rosenthal PJ, Donnelly MJ, Dorsey G, Staedke SG. Characterizing pyrethroid resistance and mechanisms in Anopheles gambiae (s.s.) and Anopheles arabiensis from 11 districts in Uganda. 2022. PMID: 36590346


  115. Sharma B, Chowdhary S, Legac J, Rosenthal PJ, Kumar V. Quinoline-based heterocyclic hydrazones: Design, synthesis, anti-plasmodial assessment, and mechanistic insights. 2022. PMID: 36418231


  116. Nachega JB, Sam-Agudu NA, Machekano RN, Rosenthal PJ, Schell S, de Waard L, Bekker A, Gachuno OW, Kinuthia J, Mwongeli N, Budhram S, Vannevel V, Somapillay P, Prozesky HW, Taljaard J, Parker A, Agyare E, Opoku AB, Makarfi AU, Abdullahi AM, Adirieje C, Ishoso DK, Pipo MT, Tshilanda MB, Bongo-Pasi Nswe C, Ditekemena J, Sigwadhi LN, Nyasulu PS, Hermans MP, Sekikubo M, Musoke P, Nsereko C, Agbeno EK, Yeboah MY, Umar LW, Ntakwinja M, Mukwege DM, Birindwa EK, Mushamuka SZ, Smith ER, Mills EJ, Otshudiema JO, Mbala-Kingebeni P, Tamfum JM, Zumla A, Tsegaye A, Mteta A, Sewankambo NK, Suleman F, Adejumo P, Anderson JR, Noormahomed EV, Deckelbaum RJ, Stringer JSA, Mukalay A, Taha TE, Fowler MG, Wasserheit JN, Masekela R, Mellors JW, Siedner MJ, Myer L, Kengne AP, Yotebieng M, Mofenson LM, Langenegger E, AFREhealth Research Collaboration on COVID-19 and Pregnancy. Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Pregnancy in Sub-Saharan Africa: A 6-Country Retrospective Cohort Analysis. 2022. PMID: 36130257


  117. Rosenthal PJ. Response to "The Importance of Exercising Caution When Comparing Results from Malaria Vaccines Administered on the EPI Schedule and on a Seasonal Schedule". 2022. PMID: 36410330


  118. Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D, King S, Squires R, Sindhi R, Venkat V, Bukauskas K, McKiernan P, Haberstroh L, Squires J, Rosenthal P, Bull L, Curry J, Langlois C, Kim G, Teckman J, Kociela V, Nagy R, Patel S, Cerkoski J, Molleston JP, Bozic M, Subbarao G, Klipsch A, Sawyers C, Cummings O, Horslen SP, Murray K, Hsu E, Cooper K, Young M, Finn L, Kamath BM, Ng V, Quammie C, Putra J, Sharma D, Parmar A, Guthery S, Jensen K, Rutherford A, Lowichik A, Book L, Meyers R, Hall T, Wang KS, Michail S, Thomas D, Goodhue C, Kohli R, Wang L, Soufi N, Thomas D, Karpen S, Gupta N, Romero R, Vos MB, Tory R, Berauer JP, Abramowsky C, McFall J, Shneider BL, Harpavat S, Hertel P, Leung D, Tessier M, Schady D, Cavallo L, Olvera D, Banks C, Tsai C, Thompson R, Doo E, Hoofnagle J, Sherker A, Torrance R, Hall S, Magee J, Merion R, Spino C, Ye W, Childhood Liver Disease Research Network. Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease. 2022. PMID: 36069569


  119. Tumwebaze PK, Conrad MD, Okitwi M, Orena S, Byaruhanga O, Katairo T, Legac J, Garg S, Giesbrecht D, Smith SR, Ceja FG, Nsobya SL, Bailey JA, Cooper RA, Rosenthal PJ. Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda. 2022. PMID: 36289202


  120. Nachega JB, Sam-Agudu NA, Siedner MJ, Rosenthal PJ, Mellors JW, Zumla A, Hermans MP, Ntakwinja MB, Mukwege DM, Langenegger E, Mofenson LM, African Forum for Research and Education in Health (AFREhealth) Research Collaboration on COVID-19 a. Prioritizing Pregnant Women for Coronavirus Disease 2019 Vaccination in African Countries. 2022. PMID: 36130226


  121. Namuganga JF, Nankabirwa JI, Maiteki-Ssebuguzi C, Gonahasa S, Opigo J, Staedke SG, Rutazaana D, Ebong C, Dorsey G, Tomko SS, Kizza T, Mawejje HD, Arinaitwe E, Rosenthal PJ, Kamya MR. East Africa International Center of Excellence for Malaria Research: Impact on Malaria Policy in Uganda. 2022. PMID: 36228904


  122. Nankabirwa JI, Rek J, Arinaitwe E, Namuganga JF, Nsobya SL, Asua V, Mawejje HD, Epstein A, Greenhouse B, Rodriguez-Barraquer I, Briggs J, Krezanoski PJ, Rosenthal PJ, Conrad M, Smith D, Staedke SG, Drakeley C, Bousema T, Andolina C, Donnelly MJ, Kamya MR, Dorsey G. East Africa International Center of Excellence for Malaria Research: Summary of Key Research Findings. 2022. PMID: 36228916


  123. Nankabirwa JI, Arinaitwe E, Briggs J, Rek J, Rosenthal PJ, Kamya MR, Olwoch P, Smith DL, Rodriguez-Barraquer I, Dorsey G, Greenhouse B. Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir. 2022. PMID: 36191870


  124. Ebel NH, Goldstein A, Howard R, Mogul DB, Marden JR, Anderson A, Gaburo K, Kirson N, Rosenthal P. Health Care Resource Utilization by Patients with Alagille Syndrome. 2022. PMID: 36179890


  125. Briggs J, Takahashi S, Nayebare P, Cuu G, Rek J, Zedi M, Kizza T, Arinaitwe E, Nankabirwa JI, Kamya M, Jagannathan P, Jacobson K, Rosenthal PJ, Dorsey G, Greenhouse B, Ssewanyana I, Rodr?guez-Barraquer I. Reconstructing the SARS-CoV-2 epidemic in eastern Uganda through longitudinal serosurveillance in a malaria cohort. 2022. PMID: 36172117


  126. Garg S, Kreutzfeld O, Chelebieva S, Tumwebaze PK, Byaruhanga O, Okitwi M, Orena S, Katairo T, Nsobya SL, Conrad MD, Aydemir O, Legac J, Gould AE, Bayles BR, Bailey JA, Duffey M, Lin G, Kirkman LA, Cooper RA, Rosenthal PJ. Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors. 2022. PMID: 36094216


  127. Hughes E, Wallender E, Kajubi R, Jagannathan P, Ochieng T, Kakuru A, Kamya MR, Clark TD, Rosenthal PJ, Dorsey G, Aweeka F, Savic RM. Piperaquine induced QTc prolongation decreases with repeated monthly dihydroartemisinin-piperaquine dosing in pregnant Ugandan women. 2021. PMID: 34864925


  128. Gupta Y, Sharma N, Singh S, Romero JG, Rajendran V, Mogire RM, Kashif M, Beach J, Jeske W, Ogutu BR, Kanzok SM, Akala HM, Legac J, Rosenthal PJ, Rademacher DJ, Durvasula R, Singh AP, Rathi B, Kempaiah P. The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca2+ Homeostasis by Targeting a Unique Ion Channel. 2022. PMID: 35890267


  129. Plucinski M, Ashley EA, Bassat Q, Venkatesan M, Rosenthal PJ, Halsey E. STARTER Checklist for Antimalarial Therapeutic Efficacy Reporting. 2022. PMID: 35880678


  130. Plucinski MM, Ashley EA, Bassat Q, Venkatesan M, Rosenthal PJ, Halsey ES. STARTER checklist for antimalarial therapeutic efficacy reporting. 2022. PMID: 35698123


  131. Shneider BL, Spino CA, Kamath BM, Magee JC, Ignacio RV, Huang S, Horslen SP, Molleston JP, Miethke AG, Kohli R, Leung DH, Jensen MK, Loomes KM, Karpen SJ, Mack C, Rosenthal P, Squires RH, Baker A, Rajwal S, Kelly D, Sokol RJ, Thompson RJ, for ChiLDReN and UK IMAGO/IMAGINE Investigators. Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome. 2022. PMID: 35672955


  132. Shneider BL, Kamath BM, Magee JC, Goodrich NP, Loomes KM, Ye W, Spino C, Alonso EM, Molleston JP, Bezerra JA, Wang KS, Karpen SJ, Horslen SP, Guthery SL, Rosenthal P, Squires RH, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Use of funded multicenter prospective longitudinal databases to inform clinical trials in rare diseases-Examination of cholestatic liver disease in Alagille syndrome. 2022. PMID: 35506349


  133. de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L, Bolscher JM, Demarta-Gatsi C, Henderson RWM, Huijs T, Koolen KMJ, Tumwebaze PK, Yeo T, Aguiar ACC, Angulo-Barturen I, Churchyard A, Baum J, Fernández BC, Fuchs A, Gamo FJ, Guido RVC, Jiménez-Diaz MB, Pereira DB, Rochford R, Roesch C, Sanz LM, Trevitt G, Witkowski B, Wittlin S, Cooper RA, Rosenthal PJ, Sauerwein RW, Schalkwijk J, Hermkens PHH, Bonnert RV, Campo B, Fidock DA, Llinás M, Niles JC, Kooij TWA, Dechering KJ. Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. 2022. PMID: 35444200


  134. Bass LM, Ye W, Hawthorne K, Leung DH, Murray KF, Molleston JP, Romero R, Karpen S, Rosenthal P, Loomes KM, Wang KS, Squires RH, Miethke A, Ng VL, Horslen S, Kyle Jensen M, Sokol RJ, Magee JC, Shneider BL, ChiLDReN. Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia. 2022. PMID: 35271743


  135. Rosenthal PJ, Björkman A, Dhorda M, Djimde A, Dondorp AM, Gaye O, Guerin PJ, Juma E, Kwiatkowski DP, Merson L, Ntoumi F, Price RN, Raman J, Roos DS, Ter Kuile F, Tinto H, Tomko SS, White NJ, Barnes KI. Cooperation in Countering Artemisinin Resistance in Africa: Learning from COVID-19. 2022. PMID: 35413688


  136. Das D, Vongpromek R, Assawariyathipat T, Srinamon K, Kennon K, Stepniewska K, Ghose A, Sayeed AA, Faiz MA, Netto RLA, Siqueira A, Yerbanga SR, Ouédraogo JB, Callery JJ, Peto TJ, Tripura R, Koukouikila-Koussounda F, Ntoumi F, Ong'echa JM, Ogutu B, Ghimire P, Marfurt J, Ley B, Seck A, Ndiaye M, Moodley B, Sun LM, Archasuksan L, Proux S, Nsobya SL, Rosenthal PJ, Horning MP, McGuire SK, Mehanian C, Burkot S, Delahunt CB, Bachman C, Price RN, Dondorp AM, Chappuis F, Guérin PJ, Dhorda M. Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning. 2022. PMID: 35413904


  137. Rosenthal PJ. Malaria in 2022: Challenges and Progress. 2022. PMID: 35413687


  138. Khalili M, Kleiner DE, King WC, Sterling RK, Ghany MG, Chung RT, Bhan AK, Rosenthal P, Lisker-Melman M, Ramachandran R, Lok AS. Reply to Li, Henry, and Nguyen. 2022. PMID: 35158369


  139. Lopes EA, Mestre R, Fontinha D, Legac J, Pei JV, Sanches-Vaz M, Mori M, Lehane AM, Rosenthal PJ, Prudêncio M, Santos MMM. Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity. 2022. PMID: 35390711


  140. Perrillo R, Lin HS, Schwarz KB, Rosenthal P, Lisker-Melman M, Chung RT, Prokunina-Olsson L, Cloherty G, Feld J, Hepatitis B Research Network (HBRN). Changes in serum hepatitis B surface and e antigen, interferon-inducible protein 10, and aminotransferase levels during combination therapy of immune-tolerant chronic hepatitis B. 2022. PMID: 35188674


  141. Huang L, Sok V, Aslam-Mir U, Marzan F, Whalen M, Rosenthal PJ, Aweeka F. Determination of unbound piperaquine in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry. 2022. PMID: 35531322


  142. Okitwi M, Orena S, Thomas K, Tumwebaze PK, Byaruhanga O, Nsobya SL, Conrad MD, Bayles BR, Rosenthal PJ, Cooper RA. Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates. 2022. PMID: 35266828


  143. Brinkmann S, Semmler S, Kersten C, Patras MA, Kurz M, Fuchs N, Hammerschmidt SJ, Legac J, Hammann PE, Vilcinskas A, Rosenthal PJ, Schirmeister T, Bauer A, Schäberle TF. Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues. 2022. PMID: 35262340


  144. Nachega JB, Sam-Agudu NA, Machekano RN, Rabie H, van der Zalm MM, Redfern A, Dramowski A, O'Connell N, Pipo MT, Tshilanda MB, Byamungu LN, Masekela R, Jeena PM, Pillay A, Gachuno OW, Kinuthia J, Ishoso DK, Amoako E, Agyare E, Agbeno EK, Martyn-Dickens C, Sylverken J, Enimil A, Jibril AM, Abdullahi AM, Amadi O, Umar UM, Sigwadhi LN, Hermans MP, Otokoye JO, Mbala-Kingebeni P, Muyembe-Tamfum JJ, Zumla A, Sewankambo NK, Aanyu HT, Musoke P, Suleman F, Adejumo P, Noormahomed EV, Deckelbaum RJ, Fowler MG, Tshilolo L, Smith G, Mills EJ, Umar LW, Siedner MJ, Kruger M, Rosenthal PJ, Mellors JW, Mofenson LM, African Forum for Research and Education in Health (AFREhealth) COVID-19 Research Collaboration on C. Assessment of Clinical Outcomes Among Children and Adolescents Hospitalized With COVID-19 in 6 Sub-Saharan African Countries. 2022. PMID: 35044430


  145. Taft BR, Yokokawa F, Kirrane T, Mata AC, Huang R, Blaquiere N, Waldron G, Zou B, Simon O, Vankadara S, Chan WL, Ding M, Sim S, Straimer J, Guiguemde A, Lakshminarayana SB, Jain JP, Bodenreider C, Thompson C, Lanshoeft C, Shu W, Fang E, Qumber J, Chan K, Pei L, Chen YL, Schulz H, Lim J, Abas SN, Ang X, Liu Y, Angulo-Barturen I, Jiménez-Díaz MB, Gamo FJ, Crespo-Fernandez B, Rosenthal PJ, Cooper RA, Tumwebaze P, Aguiar ACC, Campo B, Campbell S, Wagner J, Diagana TT, Sarko C. Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria. 2022. PMID: 35229610


  146. Kreutzfeld O, Tumwebaze PK, Byaruhanga O, Katairo T, Okitwi M, Orena S, Rasmussen SA, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Duffey M, Cooper RA, Rosenthal PJ. Decreased susceptibility to dihydrofolate reductase inhibitors associated with genetic polymorphisms in Ugandan Plasmodium falciparum isolates. 2021. PMID: 34460932


  147. Taylor SA, Venkat V, Arnon R, Gopalareddy VV, Rosenthal P, Anderson SG, Anand R, Daniel JF, Society of Pediatric Liver Transplantation. Organ-Specific Comorbidities Are Associated With Distinct Complications After Liver Transplantation for Biliary Atresia. 2021. PMID: 34821466


  148. Fidock DA, Rosenthal PJ. Artemisinin resistance in Africa: How urgent is the threat? 2021. PMID: 35005674


  149. Wallender E, Ali AM, Hughes E, Kakuru A, Jagannathan P, Muhindo MK, Opira B, Whalen M, Huang L, Duvalsaint M, Legac J, Kamya MR, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM. Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children. 2021. PMID: 34795281


  150. Kanai M, Yeo T, Asua V, Rosenthal PJ, Fidock DA, Mok S. Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing. 2021. PMID: 34694871


  151. Hertel PM, Hawthorne K, Kim S, Finegold MJ, Shneider BL, Squires JE, Gupta NA, Bull LN, Murray KF, Kerkar N, Ng VL, Molleston JP, Bezerra JA, Loomes KM, Taylor SA, Schwarz KB, Turmelle YP, Rosenthal P, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Presentation and Outcomes of Infants With Idiopathic Cholestasis: A Multicenter Prospective Study. 2021. PMID: 34310436


  152. Rosenthal PJ. Are Artemisinin-Based Combination Therapies For Malaria Beginning To Fail in Africa? 2021. PMID: 34491214


  153. Kreutzfeld O, Rasmussen SA, Ramanathan AA, Tumwebaze PK, Byaruhanga O, Katairo T, Asua V, Okitwi M, Orena S, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey J, Duffey M, Bayles BR, Vaidya AB, Cooper RA, Rosenthal PJ. Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates. 2021. PMID: 34339273


  154. Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S, Desert P, Jiménez-Díaz MB, Marfurt J, Rouillier M, Cherkaoui-Rbati MH, Gobeau N, Wittlin S, Uhlemann AC, Price RN, Wirjanata G, Noviyanti R, Tumwebaze P, Cooper RA, Rosenthal PJ, Sanz LM, Gamo FJ, Joseph J, Singh S, Bashyam S, Augereau JM, Giraud E, Bozec T, Vermat T, Tuffal G, Guillon JM, Menegotto J, Sallé L, Louit G, Cabanis MJ, Nicolas MF, Doubovetzky M, Merino R, Bessila N, Angulo-Barturen I, Baud D, Bebrevska L, Escudié F, Niles JC, Blasco B, Campbell S, Courtemanche G, Fraisse L, Pellet A, Fidock DA, Leroy D. The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. 2021. PMID: 34290058


  155. Stokes BH, Dhingra SK, Rubiano K, Mok S, Straimer J, Gnädig NF, Deni I, Schindler KA, Bath JR, Ward KE, Striepen J, Yeo T, Ross LS, Legrand E, Ariey F, Cunningham CH, Souleymane IM, Gansané A, Nzoumbou-Boko R, Ndayikunda C, Kabanywanyi AM, Uwimana A, Smith SJ, Kolley O, Ndounga M, Warsame M, Leang R, Nosten F, Anderson TJ, Rosenthal PJ, Ménard D, Fidock DA. Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. 2021. PMID: 34279219


  156. Duvalsaint M, Conrad MD, Tukwasibwe S, Tumwebaze PK, Legac J, Cooper RA, Rosenthal PJ. Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum. 2021. PMID: 34193148


  157. Ekusai-Sebatta D, Arinaitwe E, Mpimbaza A, Nankabirwa JI, Drakeley C, Rosenthal PJ, Staedke SG, Muyinda H. Challenges and opportunities for use of long-lasting insecticidal nets to prevent malaria during overnight travel in Uganda: a qualitative study. 2021. PMID: 34174892


  158. Tumwebaze PK, Katairo T, Okitwi M, Byaruhanga O, Orena S, Asua V, Duvalsaint M, Legac J, Chelebieva S, Ceja FG, Rasmussen SA, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Bayles BR, Rosenthal PJ, Cooper RA. Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study. 2021. PMID: 34553183


  159. Andolina C, Rek JC, Briggs J, Okoth J, Musiime A, Ramjith J, Teyssier N, Conrad M, Nankabirwa JI, Lanke K, Rodriguez-Barraquer I, Meerstein-Kessel L, Arinaitwe E, Olwoch P, Rosenthal PJ, Kamya MR, Dorsey G, Greenhouse B, Drakeley C, Staedke SG, Bousema T. Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study. 2021. PMID: 34146476


  160. Pal K, Raza MK, Legac J, Ataur Rahman M, Manzoor S, Rosenthal PJ, Hoda N. Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives. 2021. PMID: 34223162


  161. Karpen SJ, Kamath BM, Alexander JJ, Ichetovkin I, Rosenthal P, Sokol RJ, Dunn S, Thompson RJ, Heubi JE. Use of a Comprehensive 66-Gene Cholestasis Sequencing Panel in 2171 Cholestatic Infants, Children, and Young Adults. 2021. PMID: 33720099


  162. Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, Deni I, Lawong A, Huang A, Chen G, Wang W, Jayaseelan J, Katneni K, Patil R, Saunders J, Shahi SP, Chittimalla R, Angulo-Barturen I, Jiménez-Díaz MB, Wittlin S, Tumwebaze PK, Rosenthal PJ, Cooper RA, Aguiar ACC, Guido RVC, Pereira DB, Mittal N, Winzeler EA, Tomchick DR, Laleu B, Burrows JN, Rathod PK, Fidock DA, Charman SA, Phillips MA. Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. 2021. PMID: 33876936


  163. Rani A, Sharma A, Legac J, Rosenthal PJ, Singh P, Kumar V. A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies. 2021. PMID: 33895706


  164. Rosenthal PJ. Has artemisinin resistance emerged in Africa? 2021. PMID: 33864802


  165. Asua V, Conrad MD, Aydemir O, Duvalsaint M, Legac J, Duarte E, Tumwebaze P, Chin DM, Cooper RA, Yeka A, Kamya MR, Dorsey G, Nsobya SL, Bailey J, Rosenthal PJ. Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda. 2020. PMID: 33146722


  166. Lin G, Zhan W, Zhang H, Ginn J, Leung A, Liu YJ, Michino M, Toita A, Wong TT, Imaeda T, Hara R, Yukawa T, Chelebieva S, Tumwebaze PK, Lafuente-Monasterio MJ, Vendome J, Martinez-Martinez MS, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, Meinke PT, Nathan CF, Kirkman LA. Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice. 2021. PMID: 33433953


  167. Tukwasibwe S, Traherne JA, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jiang W, Nankabirwa JI, Rek J, Arinaitwe E, Nsobya SL, Atuheirwe M, Frank M, Godwin A, Jagannathan P, Cose S, Kamya MR, Dorsey G, Rosenthal PJ, Colucci F, Nakimuli A. Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity. 2021. PMID: 33632228


  168. Briggs J, Kuchta A, Murphy M, Tessema S, Arinaitwe E, Rek J, Chen A, Nankabirwa JI, Drakeley C, Smith D, Bousema T, Kamya M, Rodriguez-Barraquer I, Staedke S, Dorsey G, Rosenthal PJ, Greenhouse B. Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda. 2021. PMID: 33531029


  169. . Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity. 2021. PMID: 33584643


  170. Mwesigwa M, Webster JL, Nsobya SL, Rowan A, Basnet MS, Phares CR, Weinberg M, Klosovsky A, Naoum M, Rosenthal PJ, Stauffer W. Prevalence of Malaria Parasite Infections among U.S.-Bound Congolese Refugees with and without Splenomegaly. 2021. PMID: 33534754


  171. Nsobya SL, Walakira A, Namirembe E, Kiggundu M, Nankabirwa JI, Ruhamyankaka E, Arinaitwe E, Conrad MD, Kamya MR, Dorsey G, Rosenthal PJ. Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from Uganda. 2021. PMID: 33386076


  172. Rosenthal PJ. Year 100 of the American Journal of Tropical Medicine and Hygiene: A Remarkable Year. 2021. PMID: 33432913


  173. Rek J, Musiime A, Zedi M, Otto G, Kyagamba P, Asiimwe Rwatooro J, Arinaitwe E, Nankabirwa J, Staedke SG, Drakeley C, Rosenthal PJ, Kamya M, Dorsey G, Krezanoski PJ. Non-adherence to long-lasting insecticide treated bednet use following successful malaria control in Tororo, Uganda. 2020. PMID: 33270743


  174. Nayebare P, Asua V, Conrad MD, Kajubi R, Kakuru A, Nankabirwa JI, Muhanguzi D, Dorsey G, Kamya MR, Nsobya S, Rosenthal PJ. Associations between malaria preventive regimens and Plasmodium falciparum drug resistance mediating polymorphisms in Ugandan pregnant women. 2020. PMID: 33020152


  175. Hughes E, Imperial M, Wallender E, Kajubi R, Huang L, Jagannathan P, Zhang N, Kakuru A, Natureeba P, Mwima MW, Muhindo M, Mwebaza N, Clark TD, Opira B, Nakalembe M, Havlir D, Kamya M, Rosenthal PJ, Dorsey G, Aweeka F, Savic RM. Piperaquine exposure is altered by pregnancy, HIV and nutritional status in Ugandan women. 2020. PMID: 33020153


  176. Arinaitwe E, Nankabirwa JI, Krezanoski P, Rek J, Kamya V, Epstein A, Rosenthal PJ, Drakeley C, Kamya MR, Dorsey G, Staedke SG. Association between recent overnight travel and use of long-lasting insecticidal nets in rural Uganda: a prospective cohort study in Tororo. 2020. PMID: 33176793


  177. Butler JH, Baptista RP, Valenciano AL, Zhou B, Kissinger JC, Tumwebaze PK, Rosenthal PJ, Cooper R, Yue JM, Cassera MB. Resistance to some, but not other dimeric lindenane sesquiterpenoid esters is mediated by mutations in a Plasmodium falciparum esterase. 2020. PMID: 32970404


  178. Venkat V, Ng VL, Magee JC, Ye W, Hawthorne K, Harpavat S, Molleston JP, Murray KF, Wang KS, Soufi N, Bass LM, Alonso EM, Bezerra JA, Jensen MK, Kamath BM, Loomes KM, Mack CL, Rosenthal P, Shneider BL, Squires RH, Sokol RJ, Karpen SJ, Childhood Liver Disease Research Network. Modeling Outcomes in Children With Biliary Atresia With Native Liver After 2 Years of Age. 2020. PMID: 33305153


  179. Arinaitwe E, Mpimbaza A, Nankabirwa JI, Kamya V, Asiimwe A, Kuule JK, Kamya MR, Drakeley C, Dorsey G, Rosenthal PJ, Staedke SG. Malaria Diagnosed in an Urban Setting Strongly Associated with Recent Overnight Travel: A Case-Control Study from Kampala, Uganda. 2020. PMID: 32840203


  180. Cuu G, Asua V, Tukwasibwe S, Nsobya S, Mpimbaza A, Rosenthal PJ. Associations between aminoquinoline resistance genotypes and clinical presentations of Plasmodium falciparum infection in Uganda. 2020. PMID: 32660999


  181. Rosenthal PJ, Bausch DG, Goraleski KA, Hill DR, Jacobson JA, John CC, Breman JG. Keep Politics out of Funding Decisions for Medical Research and Public Health. 2020. PMID: 32700678


  182. Shneider BL, Goodrich NP, Ye W, Sawyers C, Molleston JP, Merion RM, Leung DH, Karpen SJ, Kamath BM, Cavallo L, Wang K, Teckman JH, Squires JE, Sundaram SS, Rosenthal P, Romero R, Murray KF, Loomes KM, Jensen MK, Bezerra JA, Bass LM, Sokol RJ, Magee JC, Childhood Liver Disease Research Network (ChiLDReN). Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease. 2020. PMID: 33163838


  183. Kumar S, Saini A, Legac J, Rosenthal PJ, Raj R, Kumar V. Amalgamating Isatin/Indole/Nitro-imidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial and cytotoxic evaluation. 2020. PMID: 32515142


  184. Tukwasibwe S, Nakimuli A, Traherne J, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jagannathan P, Rosenthal PJ, Cose S, Colucci F. Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria. 2020. PMID: 32541835


  185. Andrus JK, Evans-Gilbert T, Santos JI, Guzman MG, Rosenthal PJ, Toscano C, Valenzuela MT, Siqueira M, Etienne C, Breman JG. Perspectives on Battling COVID-19 in Countries of Latin America and the Caribbean. 2020. PMID: 32524963


  186. Rosenthal PJ, Breman JG, Djimde AA, John CC, Kamya MR, Leke RGF, Moeti MR, Nkengasong J, Bausch DG. COVID-19: Shining the Light on Africa. 2020. PMID: 32372749


  187. Mwebaza N, Cheah V, Forsman C, Kajubi R, Marzan F, Wallender E, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations. 2020. PMID: 32470030


  188. Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Mu J, Bayles BR, Cooper R, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX. Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. 2020. PMID: 32390431


  189. Kamath BM, Spino C, McLain R, Magee JC, Fredericks EM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Alonso EM, Murray KF, Loomes KM, Kyle Jensen M, Karpen SJ, Rosenthal P, Thomas D, Sokol RJ, Shneider BL, Childhood Liver Disease Research Network (ChiLDReN). Unraveling the Relationship Between Itching, Scratch Scales, and Biomarkers in Children With Alagille Syndrome. 2020. PMID: 32626833


  190. Blank B, Gonciarz R, Talukder P, Gut J, Legac J, Rosenthal PJ, Renslo AR. Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy. 2020. PMID: 32369341


  191. Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A, Havlir D, Jagannathan P, Rosenthal PJ, Rodriguez-Barraquer I, Dorsey G. The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018. 2020. PMID: 32431280


  192. Rosenthal PJ. The Importance of Diagnostic Testing during a Viral Pandemic: Early Lessons from Novel Coronavirus Disease (COVID-19). 2020. PMID: 32238224


  193. Verity R, Aydemir O, Brazeau NF, Watson OJ, Hathaway NJ, Mwandagalirwa MK, Marsh PW, Thwai K, Fulton T, Denton M, Morgan AP, Parr JB, Tumwebaze PK, Conrad M, Rosenthal PJ, Ishengoma DS, Ngondi J, Gutman J, Mulenga M, Norris DE, Moss WJ, Mensah BA, Myers-Hansen JL, Ghansah A, Tshefu AK, Ghani AC, Meshnick SR, Bailey JA, Juliano JJ. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. 2020. PMID: 32355199


  194. Rosenthal PJ. Are three drugs for malaria better than two? 2020. PMID: 32171077


  195. Sindhe KMV, Wu W, Legac J, Zhang YK, Easom EE, Cooper RA, Plattner JJ, Freund YR, DeRisi JL, Rosenthal PJ. Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation. 2020. PMID: 31992618


  196. Kamath BM, Ye W, Goodrich NP, Loomes KM, Romero R, Heubi JE, Leung DH, Spinner NB, Piccoli DA, Alonso EM, Guthery SL, Karpen SJ, Mack CL, Molleston JP, Murray KF, Rosenthal P, Squires JE, Teckman J, Wang KS, Thompson R, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study. 2020. PMID: 33313463


  197. Kakande E, Greenhouse B, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E, Rosenthal PJ, Kamya MR, Dorsey G, Rodriguez-Barraquer I. Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study. 2020. PMID: 31941490


  198. Rosenthal PJ. Falcipain cysteine proteases of malaria parasites: An update. 2020. PMID: 31927030


  199. Legac J, Adeniyi AA, Kisten P, Rosenthal PJ, Singh P, Kumar V. Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights. 2020. PMID: 32071682


  200. Aguiar L, Biosca A, Lantero E, Gut J, Vale N, Rosenthal PJ, Nogueira F, Andreu D, Fernàndez-Busquets X, Gomes P. Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates. 2019. PMID: 31842498


  201. Rani A, Kumar S, Legac J, Adeniyi AA, Awolade P, Singh P, Rosenthal PJ, Kumar V. Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials. 2019. PMID: 31802710


  202. Oldenburg CE, Amza A, Cooley G, Kadri B, Nassirou B, Arnold BF, Rosenthal PJ, O'Brien KS, West SK, Bailey RL, Porco TC, Keenan JD, Lietman TM, Martin DL. Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial. 2019. PMID: 31796025


  203. Kortz TB, Nyirenda J, Tembo D, Elfving K, Baltzell K, Bandawe G, Rosenthal PJ, Macfarlane SB, Mandala W, Nyirenda TS. Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis. 2019. PMID: 31595873


  204. Tilley L, Rosenthal PJ. Malaria parasites fine-tune mutations to resist drugs. 2019. PMID: 31822828


  205. Sharma B, Kaur S, Legac J, Rosenthal PJ, Kumar V. Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-ß-carboline-4-aminoquinoline conjugates. 2019. PMID: 31740250


  206. Rosenthal PJ. Be Careful What You Eat! 2019. PMID: 31549613


  207. Schwarz KB, Lombardero M, Di Bisceglie AM, Murray KF, Rosenthal P, Ling SC, Cloonan YK, Rodriguez-Baez N, Schwarzenberg SJ, Hoofnagle JH, Teckman J, Hepatitis B Research Network (HBRN). Phenotypes of Chronic Hepatitis B in Children From a Large North American Cohort. 2019. PMID: 31436702


  208. de J Parra Y, Andueza L FD, Ferrer M RE, Bruno Colmenarez J, Acosta ME, Charris J, Rosenthal PJ, Gut J. [(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity. 2019. PMID: 31762723


  209. Conrad MD, Nsobya SL, Rosenthal PJ. The diversity of the Plasmodium falciparum K13 propeller domain did not increase after implementation of artemisinin-based combination therapy in Uganda. 2019. PMID: 31358588


  210. Rosenthal PJ. Artemisinin Resistance in Eastern India. 2018. PMID: 30541018


  211. Danial E, Fleck-Derderian S, Rosenthal P. Has Rotavirus Vaccination Decreased the Prevalence of Biliary Atresia? 2019. PMID: 30222646


  212. Black DD, Mack C, Kerkar N, Miloh T, Sundaram SS, Anand R, Gupta A, Alonso E, Arnon R, Bulut P, Karpen S, Lin CH, Rosenthal P, Ryan M, Squires RH, Valentino P, Elsea SH, Shneider BL. A Prospective Trial of Withdrawal and Reinstitution of Ursodeoxycholic Acid in Pediatric Primary Sclerosing Cholangitis. 2019. PMID: 31701072


  213. Conrad MD, Rosenthal PJ. Antimalarial drug resistance in Africa: the calm before the storm? 2019. PMID: 31375467


  214. Whalen ME, Kajubi R, Chamankhah N, Huang L, Orukan F, Wallender E, Kamya MR, Dorsey G, Jagannathan P, Rosenthal PJ, Mwebaza N, Aweeka FT. Reduced exposure to piperaquine in young children, compared to adults, in children receiving dihydroartemisinin-piperaquine as malaria chemoprevention. 2019. PMID: 31173649


  215. Rosenthal PJ. A shorter course for anti-relapse therapy against vivax malaria. 2019. PMID: 31327565


  216. Guler JL, Rosenthal PJ. Mass Drug Administration to Control and Eliminate Malaria in Africa: How Do We Best Utilize the Tools at Hand? 2019. PMID: 30304408


  217. Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD. Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis. 2019. PMID: 31249291


  218. Arzika AM, Maliki R, Boubacar N, Kane S, Cotter SY, Lebas E, Cook C, Bailey RL, West SK, Rosenthal PJ, Porco TC, Lietman TM, Keenan JD. Biannual mass azithromycin distributions and malaria parasitemia in pre-school children in Niger: A cluster-randomized, placebo-controlled trial. 2019. PMID: 31237871


  219. Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G. Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. 2019. PMID: 31177777


  220. Ramesh A, Nakielny S, Hsu J, Kyohere M, Byaruhanga O, de Bourcy C, Egger R, Dimitrov B, Juan YF, Sheu J, Wang J, Kalantar K, Langelier C, Ruel T, Mpimbaza A, Wilson MR, Rosenthal PJ, DeRisi JL. Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. 2019. PMID: 31220115


  221. Mpimbaza A, Nayiga S, Ndeezi G, Rosenthal PJ, Karamagi C, Katahoire A. Understanding the context of delays in seeking appropriate care for children with symptoms of severe malaria in Uganda. 2019. PMID: 31166968


  222. Rosenthal PJ, Tan KR. Expanded Availability of Intravenous Artesunate for the Treatment of Severe Malaria in the United States. 2019. PMID: 30927931


  223. Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA, Rosenthal PJ, Grau GER, Hunt NH, Payne RJ. Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. 2019. PMID: 31062592


  224. Rani A, Legac J, Rosenthal PJ, Kumar V. Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation. 2019. PMID: 30991190


  225. Berauer JP, Mezina AI, Okou DT, Sabo A, Muzny DM, Gibbs RA, Hegde MR, Chopra P, Cutler DJ, Perlmutter DH, Bull LN, Thompson RJ, Loomes KM, Spinner NB, Rajagopalan R, Guthery SL, Moore B, Yandell M, Harpavat S, Magee JC, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Alonso EM, Rosenthal P, Squires RH, Wang KS, Finegold MJ, Russo P, Sherker AH, Sokol RJ, Karpen SJ, Childhood Liver Disease Research Network (ChiLDReN). Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome. 2019. PMID: 30664273


  226. Yeka A, Wallender E, Mulebeke R, Kibuuka A, Kigozi R, Bosco A, Kyambadde P, Opigo J, Kalyesubula S, Senzoga J, Vinden J, Conrad M, Rosenthal PJ. Comparative efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Ugandan children. 2018. PMID: 30418593


  227. Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B. Persistent parasitemia despite dramatic reduction in malaria incidence after 3 rounds of indoor residual spraying in Tororo, Uganda. 2018. PMID: 30383230


  228. Asua V, Vinden J, Conrad MD, Legac J, Kigozi SP, Kamya MR, Dorsey G, Nsobya SL, Rosenthal PJ. Changing molecular markers of antimalarial drug sensitivity across Uganda. 2018. PMID: 30559133


  229. Rosenthal PJ, John CC, Rabinovich NR. Malaria: How Are We Doing and How Can We Do Better? 2019. PMID: 30628572


  230. Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P, Havlir D, Kamya M, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM. Modeling prevention of malaria and selection of drug resistance with different dosing schedules of dihydroartemisinin-piperaquine preventive therapy during pregnancy in Uganda. 2018. PMID: 30530597


  231. Chotsiri P, Zongo I, Milligan P, Compaore YD, Somé AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B, Rosenthal PJ, White NJ, Ouédraogo JB, Tarning J. Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children. 2019. PMID: 30696903


  232. Hilk K, Zerofsky M, Rhee S, Rosenthal P, Perito ER. Center variation in screening for and management of metabolic syndrome in pediatric liver transplant recipients: A survey of SPLIT centers. 2019. PMID: 30664821


  233. Arinaitwe E, Dorsey G, Nankabirwa JI, Kigozi SP, Katureebe A, Kakande E, Rek J, Rosenthal PJ, Drakeley C, Kamya MR, Staedke SG. Association between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at Three Sites in Uganda. 2018. PMID: 29868722


  234. Rosenthal PJ, Vinetz JM, Siegel C, Kazura JW. Volume 100 of the American Journal of Tropical Medicine and Hygiene. 2019. PMID: 30652665


  235. Loomes KM, Spino C, Goodrich NP, Hangartner TN, Marker AE, Heubi JE, Kamath BM, Shneider BL, Rosenthal P, Hertel PM, Karpen SJ, Molleston JP, Murray KF, Schwarz KB, Squires RH, Teckman J, Turmelle YP, Alonso EM, Sherker AH, Magee JC, Sokol RJ, Childhood Liver Disease Research Network. Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. 2018. PMID: 30063078


  236. Mpimbaza A, Katahoire A, Rosenthal PJ, Karamagi C, Ndeezi G. Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria. 2018. PMID: 30563514


  237. Rosenthal PJ. Artemisinin Resistance Outside of Southeast Asia. 2018. PMID: 30426924


  238. Leung DH, Wirth S, Yao BB, Viani RM, Gonzalez-Peralta RP, Jonas MM, Lobritto SJ, Narkewicz MR, Sokal E, Fortuny C, Hsu EK, Del Valle-Segarra A, Zha J, Larsen L, Liu L, Shuster DL, Cohen DE, Rosenthal P. Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir and With or Without Ribavirin for Adolescents With HCV Genotype 1 or 4. 2018. PMID: 30411078


  239. Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C, Rosenthal PJ, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ. Molecular assays for antimalarial drug resistance surveillance: A target product profile. 2018. PMID: 30235327


  240. Mpimbaza A, Walakira A, Ndeezi G, Katahoire A, Karamagi C, Nsobya SL, Tukwasibwe S, Asua V, Rosenthal PJ. Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. 2018. PMID: 30222732


  241. Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT. Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine. 2018. PMID: 29547881


  242. Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. Cysteine proteases in protozoan parasites. 2018. PMID: 30138453


  243. Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. 2018. PMID: 29967165


  244. Siddiqui FA, Cabrera M, Wang M, Brashear A, Kemirembe K, Wang Z, Miao J, Chookajorn T, Yang Z, Cao Y, Dong G, Rosenthal PJ, Cui L. Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association with Artemisinin Resistance. 2018. PMID: 29659945


  245. Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM. Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz. Volume 217 of Issue 6. 2018. PMID: 29272443


  246. Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F. Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability. 2018. PMID: 29499488


  247. Katrak S, Nayebare P, Rek J, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B. Clinical consequences of submicroscopic malaria parasitaemia in Uganda. Volume 17 of Issue 1. 2018. PMID: 29402282


  248. Panosian C, Rosenthal PJ. "The Way We Were" Ken Warren's Legacy and Modern Investments in Global Health. 2017. PMID: 29187275


  249. Rasmussen SA, Ceja FG, Conrad MD, Tumwebaze PK, Byaruhanga O, Katairo T, Nsobya SL, Rosenthal PJ, Cooper RA. Changing Antimalarial Drug Sensitivities in Uganda. 2017. PMID: 28923866


  250. Rani A, Singh A, Gut J, Rosenthal PJ, Kumar V. Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation. 2017. PMID: 29174811


  251. Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E, Havlir DV, Jagannathan P, Huang L, Aweeka F, Kamya MR, Dorsey G, Rosenthal PJ. Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda. Volume 216 of Issue 8. 2017. PMID: 28968782


  252. Conrad MD, Mota D, Musiime A, Kilama M, Rek J, Kamya M, Dorsey G, Rosenthal PJ. Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda. Volume 97 of Issue 5. 2017. PMID: 29016309


  253. Mpimbaza A, Ndeezi G, Katahoire A, Rosenthal PJ, Karamagi C. Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study. 2017. PMID: 29016322


  254. Katrak S, Murphy M, Nayebare P, Rek J, Smith M, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal P, Greenhouse B. Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda. Volume 97 of Issue 6. 2017. PMID: 29016335


  255. Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ. Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. 2017. PMID: 28939159


  256. Rosenthal PJ, Goraleski KA, Rabinovich NR, Walker PF. Let's Eliminate Diseases, Not Institutes: The Case for the Fogarty International Center. 2017. PMID: 28990909


  257. Asua V, Tukwasibwe S, Conrad M, Walakira A, Nankabirwa JI, Mugenyi L, Kamya MR, Nsobya SL, Rosenthal PJ. Plasmodium Species Infecting Children Presenting with Malaria in Uganda. 2017. PMID: 28990911


  258. Wirth S, Rosenthal P, Gonzalez-Peralta RP, Jonas MM, Balistreri WF, Lin CH, Hardikar W, Kersey K, Massetto B, Kanwar B, Brainard DM, Shao J, Svarovskaia E, Kirby B, Arnon R, Murray KF, Schwarz KB. Sofosbuvir and ribavirin in adolescents 12-17 years old with hepatitis C virus genotype 2 or 3 infection. 2017. PMID: 28543053


  259. Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M. Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs). 2017. PMID: 28763614


  260. Ippolito MM, Johnson J, Mullin C, Mallow C, Morgan N, Wallender E, Li T, Rosenthal PJ. The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis. Volume 65 of Issue 3. 2017. PMID: 28402391


  261. Kumar S, Saini A, Gut J, Rosenthal PJ, Raj R, Kumar V. 4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation. 2017. PMID: 28756265


  262. O'Brien KS, Cotter SY, Amza A, Kadri B, Nassirou B, Stoller NE, Zhou Z, Cotter C, West SK, Bailey RL, Rosenthal PJ, Gaynor BD, Porco TC, Lietman TM. Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. 2017. PMID: 28722569


  263. Perito ER, Ajmera V, Bass NM, Rosenthal P, Lavine JE, Schwimmer JB, Yates KP, Diehl AM, Molleston JP, Murray KF, Scheimann A, Gill R, Glidden D, Aouizerat B. Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. 2017. PMID: 29130075


  264. Blank BR, Gut J, Rosenthal PJ, Renslo AR. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. 2017. PMID: 28692297


  265. Perito ER, Vase T, Ramachandran R, Phelps A, Jen KY, Lustig RH, Feldstein VA, Rosenthal P. Hepatic steatosis after pediatric liver transplant. 2017. PMID: 28426902


  266. Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL, Rosenthal PJ, Campo B, Gamo FJ, Sanz LM, Cao J. Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate. 2017. PMID: 28635296


  267. Shneider BL, Moore J, Kerkar N, Magee JC, Ye W, Karpen SJ, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Whitington PF, Rosenthal P, Squires RH, Guthery SL, Arnon R, Schwarz KB, Turmelle YP, Sherker AH, Sokol RJ, Childhood Liver Disease Research Network. Initial assessment of the infant with neonatal cholestasis-Is this biliary atresia? 2017. PMID: 28493866


  268. Singh A, Rani A, Gut J, Rosenthal PJ, Kumar V. Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. 2017. PMID: 28332319


  269. Tukwasibwe S, Tumwebaze P, Conrad M, Arinaitwe E, Kamya MR, Dorsey G, Nsobya SL, Greenhouse B, Rosenthal PJ. Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. 2017. PMID: 28327148


  270. Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Volume 8. 2017. PMID: 28262680


  271. Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA. Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis. 2017. PMID: 28148555


  272. Tumwebaze P, Tukwasibwe S, Taylor A, Conrad M, Ruhamyankaka E, Asua V, Walakira A, Nankabirwa J, Yeka A, Staedke SG, Greenhouse B, Nsobya SL, Kamya MR, Dorsey G, Rosenthal PJ. Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda. 2017. PMID: 28039354


  273. Ssewanyana I, Arinaitwe E, Nankabirwa JI, Yeka A, Sullivan R, Kamya MR, Rosenthal PJ, Dorsey G, Mayanja-Kizza H, Drakeley C, Greenhouse B, Tetteh KK. Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Volume 16 of Issue 1. 2017. PMID: 28183299


  274. Rosenthal PJ, Bausch DG, Higgs S, Rabinovich NR, Hill DR, Plowe CV, Goraleski KA, Walker PF. Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States. 2017. PMID: 28077738


  275. Sonoiki E, Nsanzabana C, Legac J, Sindhe KM, DeRisi J, Rosenthal PJ. Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1. 2016. PMID: 27821443


  276. Katureebe A, Zinszer K, Arinaitwe E, Rek J, Kakande E, Charland K, Kigozi R, Kilama M, Nankabirwa J, Yeka A, Mawejje H, Mpimbaza A, Katamba H, Donnelly MJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Kamya MR, Dorsey G. Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study. 2016. PMID: 27824885


  277. Rosenthal PJ, Hill DR, Bausch DG, Goraleski KA, Higgs S, Walker PF, Plowe CV. The (International) American Society of Tropical Medicine and Hygiene. 2016. PMID: 27807294


  278. Taylor AR, Flegg JA, Holmes CC, Guérin PJ, Sibley CH, Conrad MD, Dorsey G, Rosenthal PJ. Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda. 2016. PMID: 28480232


  279. Rosenthal PJ. Communicable Diseases: A Global Perspective. Volume 95 of Issue 4. 2016. PMID: 27708202


  280. Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S. Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. 2016. PMID: 27431220


  281. Nankabirwa JI, Conrad MD, Legac J, Tukwasibwe S, Tumwebaze P, Wandera B, Brooker SJ, Staedke SG, Kamya MR, Nsobya SL, Dorsey G, Rosenthal PJ. Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity. 2016. PMID: 27401569


  282. Singh A, Gut J, Rosenthal PJ, Kumar V. 4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation. 2016. PMID: 27688182


  283. Rek J, Katrak S, Obasi H, Nayebare P, Katureebe A, Kakande E, Arinaitwe E, Nankabirwa JI, Jagannathan P, Drakeley C, Staedke SG, Smith DL, Bousema T, Kamya M, Rosenthal PJ, Dorsey G, Greenhouse B. Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda. 2016. PMID: 27628178


  284. Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, Dos Santos DJ, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. 2016. PMID: 27538856


  285. Pham YH, Rosenthal P. Chronic Hepatitis C Infection in Children. 2016. PMID: 27426900


  286. Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ. Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase. Volume 60 of Issue 8. 2016. PMID: 27270277


  287. Rosenthal PJ. Azithromycin for Malaria? 2016. PMID: 27215296


  288. Ribeiro CJ, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PJ, Prudêncio M, Moreira R, Santos MM. Novel squaramides with in vitro liver stage antiplasmodial activity. 2016. PMID: 26968650


  289. Nankabirwa JI, Yeka A, Arinaitwe E, Kigozi R, Drakeley C, Kamya MR, Greenhouse B, Rosenthal PJ, Dorsey G, Staedke SG. Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction. Volume 14. 2015. PMID: 26714465


  290. Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. 2015. PMID: 26725209


  291. Yeka A, Kigozi R, Conrad MD, Lugemwa M, Okui P, Katureebe C, Belay K, Kapella BK, Chang MA, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial. 2015. PMID: 26597254


  292. Pereira NA, Monteiro Â, Machado M, Gut J, Molins E, Perry MJ, Dourado J, Moreira R, Rosenthal PJ, Prudêncio M, Santos MM. Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites. 2015. PMID: 26525306


  293. Rosenthal PJ. Artefenomel: a promising new antimalarial drug. Volume 16 of Issue 1. 2015. PMID: 26448142


  294. Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. 2015. PMID: 26617969


  295. Rosenthal PJ. The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children. 2015. PMID: 26316645


  296. Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. 2015. PMID: 26259943


  297. Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse B. Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities. Volume 112 of Issue 32. 2015. PMID: 26216993


  298. Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Sanders V, Freund YR, Campo B, Rosenthal PJ, Bu W, Gamo FJ, Sanz LM, Ge M, Li L, Ding J, Yang Y. Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles. 2015. PMID: 26067904


  299. Kibuuka A, Byakika-Kibwika P, Achan J, Yeka A, Nalyazi JN, Mpimbaza A, Rosenthal PJ, Kamya MR. Bacteremia Among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test. Volume 93 of Issue 2. 2015. PMID: 26055736


  300. Cooper RA, Conrad MD, Watson QD, Huezo SJ, Ninsiima H, Tumwebaze P, Nsobya SL, Rosenthal PJ. Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. 2015. PMID: 26033725


  301. Zongo I, Milligan P, Compaore YD, Some AF, Greenwood B, Tarning J, Rosenthal PJ, Sutherland C, Nosten F, Ouedraogo JB. Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso. 2015. PMID: 25918149


  302. . The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data. 2015. PMID: 25888957


  303. Raj R, Saini A, Gut J, Rosenthal PJ, Kumar V. Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates. 2015. PMID: 25817773


  304. Rodrigues CA, Frade RF, Albuquerque IS, Perry MJ, Gut J, Machado M, Rosenthal PJ, Prudêncio M, Afonso CA, Moreira R. Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids. 2015. PMID: 25784585


  305. Marques AF, Gomes PS, Oliveira PL, Rosenthal PJ, Pascutti PG, Lima LM. Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme. 2015. PMID: 25791019


  306. Kamya MR, Arinaitwe E, Wanzira H, Katureebe A, Barusya C, Kigozi SP, Kilama M, Tatem AJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Dorsey G. Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. Volume 92 of Issue 5. 2015. PMID: 25778501


  307. Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, Kozak B, Bloome J, Okiring J, Kakuru A, Bigira V, Kapisi J, Legac J, Gut J, Cooper RA, Kamya MR, Havlir DV, Dorsey G, Greenhouse B, Nsobya SL, Rosenthal PJ. Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. 2015. PMID: 25753626


  308. Schwartz A, Baidjoe A, Rosenthal PJ, Dorsey G, Bousema T, Greenhouse B. The Effect of Storage and Extraction Methods on Amplification of Plasmodium falciparum DNA from Dried Blood Spots. Volume 92 of Issue 5. 2015. PMID: 25758652


  309. Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J, Rosenthal PJ, Nogueira F, Egan TJ, Moreira R, Paulo A. N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity. 2015. PMID: 25725608


  310. Rosenthal PJ, Bausch DG. Perspectives on Ebola. 2015. PMID: 25582689


  311. Hsiang MS, Greenhouse B, Rosenthal PJ. Reply to Goyal et al. 2014. PMID: 25512627


  312. Conroy T, Guo JT, Elias N, Cergol KM, Gut J, Legac J, Khatoon L, Liu Y, McGowan S, Rosenthal PJ, Hunt NH, Payne RJ. Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. 2014. PMID: 25412465


  313. Sharma RK, Younis Y, Mugumbate G, Njoroge M, Gut J, Rosenthal PJ, Chibale K. Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2. 2014. PMID: 25486422


  314. Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G. Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. Volume 28 of Issue 18. 2014. PMID: 25493596


  315. Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. Drug delivery to the malaria parasite using an arterolane-like scaffold. Volume 10 of Issue 1. 2014. PMID: 25314098


  316. Jonas MM, Schwarz KB, Gonzalez-Peralta R, Lobritto S, Molleston JP, Murray KF, Rosenthal P, Wen J, Wat C, Pavlovic V, Warne C. Long-term growth outcomes in children treated for chronic hepatitis C. 2014. PMID: 25241178


  317. Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, Mårtensson A, Ngasala B, Conrad MD, Rosenthal PJ, Tshefu AK, Moormann AM, Vulule JM, Doumbo OK, Ter Kuile FO, Meshnick SR, Bailey JA, Juliano JJ. Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study. 2014. PMID: 25180240


  318. Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR, Havlir DV, Dorsey G, Rosenthal PJ. Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children. Volume 9 of Issue 8. 2014. PMID: 25144768


  319. Zongo I, Somé FA, Somda SA, Parikh S, Rouamba N, Rosenthal PJ, Tarning J, Lindegardh N, Nosten F, Ouédraogo JB. Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine. 2014. PMID: 25133389


  320. Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G. Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. Volume 11 of Issue 8. 2014. PMID: 25093754


  321. Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TM, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Björkman A, Borrmann S, Checchi F, Desai M, Dhorda M, Djimdé AA, El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher JF, Fröberg G, Grivoyannis A, Hamour S, Houzé S, Johnson J, Kamugisha E, Kariuki S, Kiechel JR, Kironde F, Kofoed PE, LeBras J, Malmberg M, Mwai L, Ngasala B, Nosten F, Nsobya SL, Nzila A, Oguike M, Otienoburu SD, Ogutu B, Ouédraogo JB, Piola P, Rombo L, Schramm B, Somé AF, Thwing J, Ursing J, Wong RP, Zeynudin A, Zongo I, Plowe CV, Sibley CH. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. 2014. PMID: 25048375


  322. . ß-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation. 2014. PMID: 25062007


  323. Raj R, Mehra V, Gut J, Rosenthal PJ, Wicht KJ, Egan TJ, Hopper M, Wrischnik LA, Land KM, Kumar V. Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity. 2014. PMID: 25038484


  324. Ng VL, Haber BH, Magee JC, Miethke A, Murray KF, Michail S, Karpen SJ, Kerkar N, Molleston JP, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Turmelle YP, Alonso EM, Sherker AH, Sokol RJ, Childhood Liver Disease Research and Education Network (CHiLDREN). Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a North American multicenter consortium. 2014. PMID: 25015575


  325. Bertoldo JB, Chiaradia-Delatorre LD, Mascarello A, Leal PC, Cordeiro MN, Nunes RJ, Sarduy ES, Rosenthal PJ, Terenzi H. Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum. 2014. PMID: 24964346


  326. Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J, Rosenthal PJ, Prudêncio M, Moreira R, O'Neill PM, Lopes F. Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials. 2014. PMID: 24824551


  327. Wanzira H, Kakuru A, Arinaitwe E, Bigira V, Muhindo MK, Conrad M, Rosenthal PJ, Kamya MR, Tappero JW, Dorsey G. Longitudinal outcomes in a cohort of Ugandan children randomized to artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of malaria. Volume 59 of Issue 4. 2014. PMID: 24825870


  328. Mbogo GW, Nankoberanyi S, Tukwasibwe S, Baliraine FN, Nsobya SL, Conrad MD, Arinaitwe E, Kamya M, Tappero J, Staedke SG, Dorsey G, Greenhouse B, Rosenthal PJ. Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda. Volume 91 of Issue 1. 2014. PMID: 24799371


  329. Hsiang MS, Greenhouse B, Rosenthal PJ. Point of care testing for malaria using LAMP, loop mediated isothermal amplification. 2014. PMID: 24795471


  330. Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid T, Guedes RC, dos Santos DJ, Rosenthal PJ, Moreira R. Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity. 2014. PMID: 24813880


  331. Kakuru A, Achan J, Muhindo MK, Ikilezi G, Arinaitwe E, Mwangwa F, Ruel T, Clark TD, Charlebois E, Rosenthal PJ, Havlir D, Kamya MR, Tappero JW, Dorsey G. Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children. Volume 59 of Issue 3. 2014. PMID: 24759826


  332. Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R. Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities. 2014. PMID: 24673163


  333. Ruel TD, Kakuru A, Ikilezi G, Mwangwa F, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Kamya M, Achan J. Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy. Volume 65 of Issue 5. 2014. PMID: 24326597


  334. Somé AF, Zongo I, Compaoré YD, Sakandé S, Nosten F, Ouédraogo JB, Rosenthal PJ. Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso. 2014. PMID: 24733476


  335. Sundararaj S, Saxena AK, Sharma R, Vashisht K, Sharma S, Anvikar A, Dixit R, Rosenthal PJ, Pandey KC. Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target. 2014. PMID: 24699522


  336. Taylor AR, Flegg JA, Nsobya SL, Yeka A, Kamya MR, Rosenthal PJ, Dorsey G, Sibley CH, Guerin PJ, Holmes CC. Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections. 2014. PMID: 24636676


  337. Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Forge D, Kumar V. 7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation. 2014. PMID: 24341638


  338. Nankoberanyi S, Mbogo GW, LeClair NP, Conrad MD, Tumwebaze P, Tukwasibwe S, Kamya MR, Tappero J, Nsobya SL, Rosenthal PJ. Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda. 2014. PMID: 24629020


  339. Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N, Dorsey G, Rosenthal PJ, Brooker SJ, Staedke SG, Kamya MR. Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. Volume 58 of Issue 10. 2014. PMID: 24621953


  340. Gaynor BD, Amza A, Kadri B, Nassirou B, Lawan O, Maman L, Stoller NE, Yu SN, Chin SA, West SK, Bailey RL, Rosenthal PJ, Keenan JD, Porco TC, Lietman TM. Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. Volume 90 of Issue 5. 2014. PMID: 24615132


  341. Conrad MD, LeClair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW, Greenhouse B, Dorsey G, Rosenthal PJ. Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children. Volume 210 of Issue 3. 2014. PMID: 24610872


  342. Weldon DJ, Shah F, Chittiboyina AG, Sheri A, Chada RR, Gut J, Rosenthal PJ, Shivakumar D, Sherman W, Desai P, Jung JC, Avery MA. Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of a-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum. 2014. PMID: 24507921


  343. Tukwasibwe S, Mugenyi L, Mbogo GW, Nankoberanyi S, Maiteki-Sebuguzi C, Joloba ML, Nsobya SL, Staedke SG, Rosenthal PJ. Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. Volume 210 of Issue 1. 2014. PMID: 24446524


  344. Raj R, Gut J, Rosenthal PJ, Kumar V. 1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation. 2014. PMID: 24424135


  345. Rosenthal PJ. Changes at our journal. 2014. PMID: 24402700


  346. Kjellin LL, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS. Volume 6 of Issue 23. 2014. PMID: 25529877


  347. Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O'Neill PM, Lopes F. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. 2013. PMID: 24900781


  348. Singh P, Raj R, Singh P, Gut J, Rosenthal PJ, Kumar V. Urea/oxalamide tethered ß-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation. 2013. PMID: 24287561


  349. Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Kumar V. 4-Aminoquinoline-ß-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation. 2013. PMID: 24034147


  350. Mugumbate G, Newton AS, Rosenthal PJ, Gut J, Moreira R, Chibale K, Guedes RC. Novel anti-plasmodial hits identified by virtual screening of the ZINC database. 2013. PMID: 24158745


  351. Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds. 2013. PMID: 24900630


  352. Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O'Neill P, Mota MM, Lopes F, Moreira R. Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability. 2013. PMID: 24020770


  353. Rodrigues T, Ressurreição AS, da Cruz FP, Albuquerque IS, Gut J, Carrasco MP, Gonçalves D, Guedes RC, dos Santos DJ, Mota MM, Rosenthal PJ, Moreira R, Prudêncio M, Lopes F. Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. 2013. PMID: 24125849


  354. Ribeiro CJ, Kumar SP, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM. Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents. 2013. PMID: 24077527


  355. Gong L, Parikh S, Rosenthal PJ, Greenhouse B. Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Volume 12. 2013. PMID: 24025776


  356. Prasad R. Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. 2013. PMID: 24023882


  357. Rosenthal PJ. The interplay between drug resistance and fitness in malaria parasites. Volume 89 of Issue 6. 2013. PMID: 23899091


  358. Mba'ning BM, Lenta BN, Noungoué DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF, Rosenthal PJ, Tsamo E, Sewald N, Laatsch H. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. 2013. PMID: 23863332


  359. Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O'Neill PM, Ward SA, Lopes F, Moreira R. An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites. 2013. PMID: 23853126


  360. Tukulula M, Njoroge M, Mugumbate GC, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K. Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents. 2013. PMID: 23896611


  361. Schuck DC, Ferreira SB, Cruz LN, da Rocha DR, Moraes MS, Nakabashi M, Rosenthal PJ, Ferreira VF, Garcia CR. Biological evaluation of hydroxynaphthoquinones as anti-malarials. 2013. PMID: 23841934


  362. Gantt S, Huang ML, Magaret A, Bunts L, Selke S, Wald A, Rosenthal PJ, Dorsey G, Casper C. An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia. Volume 58 of Issue 1. 2013. PMID: 23827788


  363. Ochong E, Tumwebaze PK, Byaruhanga O, Greenhouse B, Rosenthal PJ. Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites. 2013. PMID: 23796921


  364. Carrasco MP, Gut J, Rodrigues T, Ribeiro MH, Lopes F, Rosenthal PJ, Moreira R, Dos Santos DJ. Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits. 2013. PMID: 27481771


  365. LeClair NP, Conrad MD, Baliraine FN, Nsanzabana C, Nsobya SL, Rosenthal PJ. Optimization of a ligase detection reaction-fluorescent microsphere assay for characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum. 2013. PMID: 23720790


  366. Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R. Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria. 2013. PMID: 23701465


  367. Njogu PM, Gut J, Rosenthal PJ, Chibale K. Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine. 2013. PMID: 24900723


  368. Andayi WA, Egan TJ, Gut J, Rosenthal PJ, Chibale K. Synthesis, Antiplasmodial Activity, and ß-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids. 2013. PMID: 24900724


  369. Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. In vitro and in vivo antimalarial efficacies of optimized tetracyclines. 2013. PMID: 23629719


  370. Marques AF, Esser D, Rosenthal PJ, Kassack MU, Lima LM. Falcipain-2 inhibition by suramin and suramin analogues. 2013. PMID: 23680445


  371. Raj R, Singh P, Singh P, Gut J, Rosenthal PJ, Kumar V. Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: synthesis and antimalarial evaluation. 2013. PMID: 23434528


  372. Ikilezi G, Achan J, Kakuru A, Ruel T, Charlebois E, Clark TD, Rosenthal PJ, Havlir D, Kamya MR, Dorsey G. Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies. 2013. PMID: 23358639


  373. Cotrin SS, Gouvêa IE, Melo PM, Bagnaresi P, Assis DM, Araújo MS, Juliano MA, Gazarini ML, Rosenthal PJ, Juliano L, Carmona AK. Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity. 2013. PMID: 23354130


  374. Pérez BC, Teixeira C, Albuquerque IS, Gut J, Rosenthal PJ, Gomes JR, Prudêncio M, Gomes P. N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads. 2013. PMID: 23273038


  375. Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G. Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. 2012. PMID: 23273022


  376. Pérez B, Teixeira C, Gomes AS, Albuquerque IS, Gut J, Rosenthal PJ, Prudêncio M, Gomes P. In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites. 2012. PMID: 23290049


  377. Keh CE, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M, Rosenthal PJ, Dorsey G, Nixon DF, Greenhouse B. Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda. Volume 7 of Issue 12. 2012. PMID: 23285095


  378. Baltzell KA, Shakely D, Hsiang M, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal PJ, Greenhouse B. Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar. 2012. PMID: 23249688


  379. Mahajan SS, Gut J, Rosenthal PJ, Renslo AR. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite. 2012. PMID: 23234548


  380. Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR. Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. 2012. PMID: 23190222


  381. Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ. Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo. 2012. PMID: 23171238


  382. Huang L, Parikh S, Rosenthal PJ, Lizak P, Marzan F, Dorsey G, Havlir D, Aweeka FT. Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers. Volume 61 of Issue 3. 2012. PMID: 22918158


  383. Lu X, Altharawi A, Gut J, Rosenthal PJ, Long TE. 1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues. 2012. PMID: 24936235


  384. Pérez B, Teixeira C, Gut J, Rosenthal PJ, Gomes JR, Gomes P. Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum. 2012. PMID: 22753234


  385. Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation. 2012. PMID: 22749280


  386. Pérez BC, Teixeira C, Figueiras M, Gut J, Rosenthal PJ, Gomes JR, Gomes P. Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials. 2012. PMID: 22683112


  387. Bagnaresi P, Barros NM, Assis DM, Melo PM, Fonseca RG, Juliano MA, Pesquero JB, Juliano L, Rosenthal PJ, Carmona AK, Gazarini ML. Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins. 2012. PMID: 22564457


  388. Shah F, Gut J, Legac J, Shivakumar D, Sherman W, Rosenthal PJ, Avery MA. Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis. 2012. PMID: 22332946


  389. Long TE, Lu X, Galizzi M, Docampo R, Gut J, Rosenthal PJ. Phosphonium lipocations as antiparasitic agents. 2012. PMID: 22414614


  390. Gong L, Maiteki-Sebuguzi C, Rosenthal PJ, Hubbard AE, Drakeley CJ, Dorsey G, Greenhouse B. Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait. Volume 119 of Issue 16. 2012. PMID: 22327223


  391. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK. Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Volume 54 of Issue 7. 2012. PMID: 22308272


  392. Rosenthal PJ. How do we best diagnose malaria in Africa? 2012. PMID: 22302846


  393. Kamya MR, Byakika-Kibwika P, Gasasira AF, Havlir D, Rosenthal PJ, Dorsey G, Achan J. The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa. 2012. PMID: 23293660


  394. Matos J, da Cruz FP, Cabrita É, Gut J, Nogueira F, do Rosário VE, Moreira R, Rosenthal PJ, Prudêncio M, Gomes P. Novel potent metallocenes against liver stage malaria. 2011. PMID: 22155838


  395. Singh P, Singh P, Kumar M, Gut J, Rosenthal PJ, Kumar K, Kumar V, Mahajan MP, Bisetty K. Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from ß-lactams and 7-chloroquinoline using click chemistry. 2011. PMID: 22172698


  396. Makanga M, Bassat Q, Falade CO, Premji ZG, Krudsood S, Hunt P, Walter V, Beck HP, Marrast AC, Cousin M, Rosenthal PJ. Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis. 2011. PMID: 22049029


  397. Gupta V, Perez-Perez GI, Dorsey G, Rosenthal PJ, Blaser MJ. The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children. Volume 106 of Issue 1. 2011. PMID: 22018600


  398. Glória PM, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM. Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents. 2011. PMID: 22071522


  399. Baliraine FN, Rosenthal PJ. Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda. 2011. PMID: 21881128


  400. Rodrigues T, Moreira R, Gut J, Rosenthal PJ, O Neill PM, Biagini GA, Lopes F, dos Santos DJ, Guedes RC. Identification of new antimalarial leads by use of virtual screening against cytochrome bc1. 2011. PMID: 21958736


  401. Nsanzabana C, Rosenthal PJ. In vitro activity of antiretroviral drugs against Plasmodium falciparum. 2011. PMID: 21876053


  402. Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, do Rosário VE, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola. 2011. PMID: 21864379


  403. Capela R, Cabal GG, Rosenthal PJ, Gut J, Mota MM, Moreira R, Lopes F, Prudêncio M. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy. 2011. PMID: 21807973


  404. Kemgne EA, Mbacham WF, Boyom FF, Zollo PH, Tsamo E, Rosenthal PJ. In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants. 2011. PMID: 21739316


  405. Talisuna A, Adibaku S, Dorsey G, Kamya MR, Rosenthal PJ. Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward. Volume 121 of Issue 3. 2011. PMID: 21756863


  406. Greenhouse B, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S, Rosenthal PJ, Dorsey G, John CC. Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. Volume 204 of Issue 1. 2011. PMID: 21628654


  407. Rosenthal PJ. Lessons from sickle cell disease in the treatment and control of malaria. 2011. PMID: 21714653


  408. Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, Tilley L. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. 2011. PMID: 21709259


  409. Langolf S, Machon U, Ehlers M, Sicking W, Schirmeister T, Büchhold C, Gelhaus C, Rosenthal PJ, Schmuck C. Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks. 2011. PMID: 21678556


  410. Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. 2011. PMID: 21609473


  411. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies. 2011. PMID: 21500839


  412. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. 2011. PMID: 21572521


  413. Shah F, Mukherjee P, Gut J, Legac J, Rosenthal PJ, Tekwani BL, Avery MA. Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library. 2011. PMID: 21428453


  414. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ. Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Volume 121 of Issue 3. 2011. PMID: 21420377


  415. Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. 2011. PMID: 21376591


  416. Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. An image-based assay for high throughput screening of Giardia lamblia. 2011. PMID: 21262276


  417. Boyom FF, Fokou PV, Yamthe LR, Mfopa AN, Kemgne EM, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ. Potent antiplasmodial extracts from Cameroonian Annonaceae. 2011. PMID: 21256952


  418. Praveen Kumar S, Gut J, Guedes RC, Rosenthal PJ, Santos MM, Moreira R. Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. 2011. PMID: 21295887


  419. Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. 2011. PMID: 21207937


  420. Büchold C, Hemberger Y, Heindl C, Welker A, Degel B, Pfeuffer T, Staib P, Schneider S, Rosenthal PJ, Gut J, Morschhäuser J, Bringmann G, Schirmeister T. New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors. 2011. PMID: 21082722


  421. Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J. Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children. Volume 56 of Issue 1. 2011. PMID: 21099693


  422. Rosenthal PJ. Falcipains and other cysteine proteases of malaria parasites. 2011. PMID: 21660657


  423. Cruz LN, Alves E, Leal MT, Juliano MA, Rosenthal PJ, Juliano L, Garcia CR. FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii. 2010. PMID: 21168413


  424. Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Gut J, Rosenthal PJ, Waterson D, Gamo FJ, Angulo-Barturen I, Ge M, Li Z, Li L, Jian Y, Cui H, Wang H, Yang J. Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents. 2010. PMID: 21195617


  425. Gama BE, de Oliveira NK, de Souza JM, Santos F, de Carvalho LJ, Melo YF, Rosenthal PJ, Daniel-Ribeiro CT, Ferreira-da-Cruz Mde F. Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy. 2010. PMID: 21143867


  426. Boyom FF, Ngouana V, Kemgne EA, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ. Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. 2010. PMID: 21107862


  427. Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO, Greenhouse B, Rosenthal PJ. Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. 2010. PMID: 21078941


  428. Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J, Rosenthal PJ, Avery MA. Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents. 2010. PMID: 20945914


  429. Charlebois ED, Ruel TD, Gasasira AF, Achan J, Kateera F, Akello C, Cao H, Dorsey G, Rosenthal PJ, Ssewanyana I, Kamya MR, Havlir DV. Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy. Volume 55 of Issue 3. 2010. PMID: 20592617


  430. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds. 2010. PMID: 21044845


  431. Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. 2010. PMID: 20979352


  432. Nankabirwa J, Cundill B, Clarke S, Kabatereine N, Rosenthal PJ, Dorsey G, Brooker S, Staedke SG. Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren. Volume 5 of Issue 10. 2010. PMID: 20976051


  433. Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y. Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. 2010. PMID: 20967286


  434. Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK. Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes. Volume 170 of Issue 1-2. 2010. PMID: 20863855


  435. Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval E, Ventosa P, Rosenthal PJ, Fiandor JM. Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series. 2010. PMID: 20672841


  436. Lavrado J, Gani K, Nobre PA, Santos SA, Figueiredo P, Lopes D, Rosário Vd, Gut J, Rosenthal PJ, Moreira R, Paulo A. Bis-alkylamine quindolone derivatives as new antimalarial leads. 2010. PMID: 20801652


  437. Bebell LM, Pilcher CD, Dorsey G, Havlir D, Kamya MR, Busch MP, Dunn Williams J, Nugent CT, Bentsen C, Rosenthal PJ, Charlebois ED. Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. Volume 24 of Issue 12. 2010. PMID: 20543656


  438. Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Greenhouse B, Staedke SG, Kamya MR, Dorsey G, Rosenthal PJ. Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children. Volume 5 of Issue 7. 2010. PMID: 20689585


  439. Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J, Rosenthal PJ, Chibale K. Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity. 2010. PMID: 20621360


  440. Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G. Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance. Volume 9. 2010. PMID: 20573194


  441. Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene. 2010. PMID: 20565881


  442. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Chemical genetics of Plasmodium falciparum. 2010. PMID: 20485428


  443. Sijwali PS, Rosenthal PJ. Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export. 2010. PMID: 20419102


  444. Somé AF, Séré YY, Dokomajilar C, Zongo I, Rouamba N, Greenhouse B, Ouédraogo JB, Rosenthal PJ. Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso. 2010. PMID: 20231394


  445. Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T. Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. 2010. PMID: 20131843


  446. Hans RH, Gut J, Rosenthal PJ, Chibale K. Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids. 2010. PMID: 20206517


  447. Gupta V, Dorsey G, Hubbard AE, Rosenthal PJ, Greenhouse B. Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda. Volume 9. 2010. PMID: 20074380


  448. Nsobya SL, Kiggundu M, Nanyunja S, Joloba M, Greenhouse B, Rosenthal PJ. In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. 2010. PMID: 20065051


  449. Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. 2009. PMID: 20045640


  450. Vale N, Prudêncio M, Marques CA, Collins MS, Gut J, Nogueira F, Matos J, Rosenthal PJ, Cushion MT, do Rosário VE, Mota MM, Moreira R, Gomes P. Imidazoquines as antimalarial and antipneumocystis agents. 2009. PMID: 19799426


  451. Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Volume 49 of Issue 11. 2009. PMID: 19877969


  452. Nawaz F, Nsobya SL, Kiggundu M, Joloba M, Rosenthal PJ. Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda. 2009. PMID: 19905933


  453. Newman PM, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J, Havlir D, Rosenthal PJ, Dorsey G, Clark TD, Cohan D. Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda. Volume 8. 2009. PMID: 19912657


  454. Löser R, Gut J, Rosenthal PJ, Frizler M, Gütschow M, Andrews KT. Antimalarial activity of azadipeptide nitriles. 2009. PMID: 19913414


  455. Mwesigwa J, Parikh S, McGee B, German P, Drysdale T, Kalyango JN, Clark TD, Dorsey G, Lindegardh N, Annerberg A, Rosenthal PJ, Kamya MR, Aweeka F. Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda. Volume 54 of Issue 1. 2009. PMID: 19841149


  456. Johnson MK, Clark TD, Njama-Meya D, Rosenthal PJ, Parikh S. Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility. 2009. PMID: 19789650


  457. Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C. On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. 2009. PMID: 19715342


  458. Lavine JE, Schwimmer JB, Molleston JP, Scheimann AO, Murray KF, Abrams SH, Rosenthal P, Sanyal AJ, Robuck PR, Brunt EM, Unalp A, Tonascia J. Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Volume 31 of Issue 1. 2009. PMID: 19761871


  459. Jensen TP, Bukirwa H, Njama-Meya D, Francis D, Kamya MR, Rosenthal PJ, Dorsey G. Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children. Volume 8. 2009. PMID: 19754955


  460. Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, Martin JN. Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission. Volume 200 of Issue 3. 2009. PMID: 19534596


  461. German P, Parikh S, Lawrence J, Dorsey G, Rosenthal PJ, Havlir D, Charlebois E, Hanpithakpong W, Lindegardh N, Aweeka FT. Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. Volume 51 of Issue 4. 2009. PMID: 19506482


  462. Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO. Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. Volume 339. 2009. PMID: 19622553


  463. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. 2009. PMID: 19620707


  464. Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK. Antiparasitic activities of novel, orally available fumagillin analogs. 2009. PMID: 19648008


  465. Mpimbaza A, Staedke SG, Ndeezi G, Byarugaba J, Rosenthal PJ. Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. 2009. PMID: 19563665


  466. Pandey KC, Barkan DT, Sali A, Rosenthal PJ. Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum. 2009. PMID: 19479029


  467. Rodrigues T, Guedes RC, dos Santos DJ, Carrasco M, Gut J, Rosenthal PJ, Moreira R, Lopes F. Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. 2009. PMID: 19467600


  468. Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J, Rosenthal PJ, Lopes F, Moreira R. Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition. 2009. PMID: 19435664


  469. Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. 2009. PMID: 19357776


  470. Staedke SG, Mwebaza N, Kamya MR, Clark TD, Dorsey G, Rosenthal PJ, Whitty CJ. Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial. Volume 373 of Issue 9675. 2009. PMID: 19362361


  471. Mobula L, Lilley B, Tshefu AK, Rosenthal PJ. Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo. 2009. PMID: 19346374


  472. Boyom FF, Kemgne EM, Tepongning R, Ngouana V, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ. Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon. 2009. PMID: 19442463


  473. Noungoue DT, Chaabi M, Ngouela S, Antheaume C, Boyom FF, Gut J, Rosenthal PJ, Lobstein A, Tsamo E. Antimalarial compounds from the stem bark of Vismia laurentii. 2009. PMID: 19526714


  474. Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Clark TD, Staedke SG, Kamya MR, Hubbard A, Rosenthal PJ, Dorsey G. Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance. Volume 199 of Issue 5. 2009. PMID: 19199542


  475. Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. 2009. PMID: 19128015


  476. Ssewanyana I, Baker CA, Ruel T, Bousheri S, Kamya M, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Cao H. The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda. Volume 25 of Issue 1. 2009. PMID: 19182922


  477. Dude MA, Kaeppler U, Herb M, Schiller M, Schulz F, Vedder B, Heppner S, Pradel G, Gut J, Rosenthal PJ, Schirmeister T, Leippe M, Gelhaus C. Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid. 2008. PMID: 19104483


  478. McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. Development of protease inhibitors for protozoan infections. 2008. PMID: 18978536


  479. Nsobya SL, Kiggundu M, Joloba M, Dorsey G, Rosenthal PJ. Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture. Volume 198 of Issue 10. 2008. PMID: 18808336


  480. Parikh S, Rosenthal PJ. Human genetics and malaria: relevance for the design of clinical trials. 2008. PMID: 18752442


  481. Dominguez JN, Leon C, Rodrigues J, Gamboa de Dominguez N, Gut J, Rosenthal PJ. Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities. 2008. PMID: 19036479


  482. Kim CC, Parikh S, Sun JC, Myrick A, Lanier LL, Rosenthal PJ, DeRisi JL. Experimental malaria infection triggers early expansion of natural killer cells. 2008. PMID: 18824529


  483. Clark TD, Greenhouse B, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Staedke SG, Seto E, Kamya MR, Rosenthal PJ, Dorsey G. Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. Volume 198 of Issue 3. 2008. PMID: 18522503


  484. Yeka A, Dorsey G, Kamya MR, Talisuna A, Lugemwa M, Rwakimari JB, Staedke SG, Rosenthal PJ, Wabwire-Mangen F, Bukirwa H. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. Volume 3 of Issue 6. 2008. PMID: 18545692


  485. Staedke SG, Jagannathan P, Yeka A, Bukirwa H, Banek K, Maiteki-Sebuguzi C, Clark TD, Nzarubara B, Njama-Meya D, Mpimbaza A, Rosenthal PJ, Kamya MR, Wabwire-Mangen F, Dorsey G, Talisuna AO. Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. Volume 7. 2008. PMID: 18547416


  486. Maiteki-Sebuguzi C, Jagannathan P, Yau VM, Clark TD, Njama-Meya D, Nzarubara B, Talisuna AO, Kamya MR, Rosenthal PJ, Dorsey G, Staedke SG. Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. Volume 7. 2008. PMID: 18547415


  487. Ruel TD, Achan J, Gasasira AF, Charlebois ED, Mehbratu T, Rosenthal PJ, Dorsey G, Kamya MR, Kekitiinwa A, Wong J, Havlir DV. HIV RNA suppression among HIV-infected Ugandan children with measles. Volume 48 of Issue 2. 2008. PMID: 18520684


  488. Vale N, Matos J, Gut J, Nogueira F, do Rosário V, Rosenthal PJ, Moreira R, Gomes P. Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity. 2008. PMID: 18539459


  489. Angulo-Barturen I, Jiménez-Díaz MB, Mulet T, Rullas J, Herreros E, Ferrer S, Jiménez E, Mendoza A, Regadera J, Rosenthal PJ, Bathurst I, Pompliano DL, Gómez de las Heras F, Gargallo-Viola D. A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. 2008. PMID: 18493601


  490. Verissimo E, Berry N, Gibbons P, Cristiano ML, Rosenthal PJ, Gut J, Ward SA, O'Neill PM. Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. 2008. PMID: 18554905


  491. Dahl EL, Rosenthal PJ. Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. 2008. PMID: 18450512


  492. Rosenthal PJ. Artesunate for the treatment of severe falciparum malaria. 2008. PMID: 18434652


  493. Mehlotra RK, Mattera G, Bockarie MJ, Maguire JD, Baird JK, Sharma YD, Alifrangis M, Dorsey G, Rosenthal PJ, Fryauff DJ, Kazura JW, Stoneking M, Zimmerman PA. Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Volume 52 of Issue 6. 2008. PMID: 18411325


  494. Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ, Havlir D, Dorsey G. High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Volume 46 of Issue 7. 2008. PMID: 18444813


  495. Ngouamegne ET, Fongang RS, Ngouela S, Boyom FF, Rohmer M, Tsamo E, Gut J, Rosenthal PJ. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. 2008. PMID: 18310952


  496. Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE. Plasmodium food vacuole plasmepsins are activated by falcipains. 2008. PMID: 18308731


  497. Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G. Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. Volume 197 of Issue 4. 2008. PMID: 18240951


  498. Ndjakou Lenta B, Devkota KP, Ngouela S, Fekam Boyom F, Naz Q, Choudhary MI, Tsamo E, Rosenthal PJ, Sewald N. Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. 2008. PMID: 18239315


  499. Lavrado J, Paulo A, Gut J, Rosenthal PJ, Moreira R. Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity. 2008. PMID: 18207399


  500. Mpimbaza A, Ndeezi G, Staedke S, Rosenthal PJ, Byarugaba J. Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. 2008. PMID: 18166545


  501. Bebell LM, Gasasira A, Kiggundu M, Dokomajilar C, Kamya MR, Charlebois ED, Havlir D, Rosenthal PJ, Dorsey G. HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda. Volume 46 of Issue 5. 2007. PMID: 18043317


  502. Vale N, Collins MS, Gut J, Ferraz R, Rosenthal PJ, Cushion MT, Moreira R, Gomes P. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. 2007. PMID: 18077165


  503. Ssewanyana I, Pietras C, Baker CA, Nghania F, Jones NG, Rosenthal PJ, Dorsey G, Cao H. Pattern of malaria-specific T-cell responses in a cohort of Ugandan children. Volume 54 of Issue 1. 2007. PMID: 17984125


  504. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Séré Y, Rosenthal PJ, Ouédraogo JB. Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Volume 45 of Issue 11. 2007. PMID: 17990228


  505. Biot C, Pradines B, Sergeant MH, Gut J, Rosenthal PJ, Chibale K. Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues. 2007. PMID: 17949976


  506. Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G. Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. Volume 21 of Issue 15. 2007. PMID: 17885296


  507. Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, Mbacham W, Meshnick SR, Mugittu K, Naidoo I, Price RN, Shafer RW, Sibley CH, Sutherland CJ, Zimmerman PA, Rosenthal PJ. World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. 2007. PMID: 17822535


  508. Dahl EL, Rosenthal PJ. Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. 2007. PMID: 17698630


  509. Schulz F, Gelhaus C, Degel B, Vicik R, Heppner S, Breuning A, Leippe M, Gut J, Rosenthal PJ, Schirmeister T. Screening of protease inhibitors as antiplasmodial agents. Part I: Aziridines and epoxides. 2007. PMID: 17562535


  510. Greenhouse B, Dokomajilar C, Hubbard A, Rosenthal PJ, Dorsey G. Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials. Volume 51 of Issue 9. 2007. PMID: 17591848


  511. Subramanian S, Sijwali PS, Rosenthal PJ. Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole. 2007. PMID: 17565983


  512. Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Volume 51 of Issue 8. 2007. PMID: 17562798


  513. Hopkins H, Kambale W, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda. Volume 76 of Issue 6. 2007. PMID: 17556616


  514. Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ. Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. Volume 297 of Issue 20. 2007. PMID: 17519410


  515. Kamya MR, Yeka A, Bukirwa H, Lugemwa M, Rwakimari JB, Staedke SG, Talisuna AO, Greenhouse B, Nosten F, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. Volume 2 of Issue 5. 2007. PMID: 17525792


  516. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. 2007. PMID: 17502099


  517. Singh A, Walker KJ, Sijwali PS, Lau AL, Rosenthal PJ. A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2. 2007. PMID: 17430972


  518. German P, Greenhouse B, Coates C, Dorsey G, Rosenthal PJ, Charlebois E, Lindegardh N, Havlir D, Aweeka FT. Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz. Volume 44 of Issue 6. 2007. PMID: 17304470


  519. Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL. Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. 2007. PMID: 17361129


  520. Ndjakou Lenta B, Ngouela S, Fekam Boyom F, Tantangmo F, Feuya Tchouya GR, Tsamo E, Gut J, Rosenthal PJ, Donald Connolly J. Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae). 2007. PMID: 17329893


  521. Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB. Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Volume 369 of Issue 9560. 2007. PMID: 17292769


  522. León C, Rodrigues J, Gamboa de Domínguez N, Charris J, Gut J, Rosenthal PJ, Domínguez JN. Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials. 2007. PMID: 17321641


  523. Collins WJ, Greenhouse B, Rosenthal PJ, Dorsey G. The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005. Volume 5. 2006. PMID: 17169157


  524. Pandey KC, Singh N, Arastu-Kapur S, Bogyo M, Rosenthal PJ. Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. 2006. PMID: 17083274


  525. Greenhouse B, Myrick A, Dokomajilar C, Woo JM, Carlson EJ, Rosenthal PJ, Dorsey G. Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections. Volume 75 of Issue 5. 2006. PMID: 17123974


  526. Chipeleme A, Gut J, Rosenthal PJ, Chibale K. Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum. 2006. PMID: 17052908


  527. Malamba SS, Mermin J, Reingold A, Lule JR, Downing R, Ransom R, Kigozi A, Hunt BM, Hubbard A, Rosenthal PJ, Dorsey G. Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members. Volume 75 of Issue 3. 2006. PMID: 16968909


  528. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. 2006. PMID: 16940111


  529. Gasasira AF, Dorsey G, Kamya MR, Havlir D, Kiggundu M, Rosenthal PJ, Charlebois ED. False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria. Volume 44 of Issue 8. 2006. PMID: 16891532


  530. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. 2006. PMID: 16864794


  531. Sijwali PS, Koo J, Singh N, Rosenthal PJ. Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum. 2006. PMID: 16890302


  532. Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ. Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Volume 75 of Issue 1. 2006. PMID: 16837725


  533. Parikh S, Liu J, Sijwali P, Gut J, Goldberg DE, Rosenthal PJ. Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin. 2006. PMID: 16723585


  534. Hwang J, Bitarakwate E, Pai M, Reingold A, Rosenthal PJ, Dorsey G. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review. Volume 11 of Issue 6. 2006. PMID: 16771999


  535. Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, Bakyaita N, Rwakimari JB, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, Staedke SG. Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. Volume 1 of Issue 1. 2006. PMID: 16871329


  536. Valente C, Guedes RC, Moreira R, Iley J, Gut J, Rosenthal PJ. Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum. 2006. PMID: 16697641


  537. Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K. Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. 2006. PMID: 16690319


  538. Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G. Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Volume 50 of Issue 5. 2006. PMID: 16641472


  539. Myrick A, Leemann E, Dokomajilar C, Hopkins H, Dorsey G, Kamya MR, Rosenthal PJ. Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda. Volume 74 of Issue 5. 2006. PMID: 16687676


  540. Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G. Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda. Volume 193 of Issue 8. 2006. PMID: 16544257


  541. Desai PV, Patny A, Gut J, Rosenthal PJ, Tekwani B, Srivastava A, Avery M. Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory. 2006. PMID: 16509575


  542. Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G. Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. Volume 193 of Issue 7. 2006. PMID: 16518760


  543. Eggena MP, Hopkins H, Barugahare B, Okello M, Ssali F, Mugyenyi P, Rosenthal PJ, Cao H, Dorsey G. CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria. Volume 74 of Issue 1. 2006. PMID: 16407344


  544. Ngouela S, Lenta BN, Noungoue DT, Ngoupayo J, Boyom FF, Tsamo E, Gut J, Rosenthal PJ, Connolly JD. Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f. 2005. PMID: 16368120


  545. Singh N, Sijwali PS, Pandey KC, Rosenthal PJ. Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'. 2005. PMID: 16337629


  546. Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D. Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. Volume 193 of Issue 1. 2005. PMID: 16323126


  547. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB, Rosenthal PJ. Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso. Volume 73 of Issue 5. 2005. PMID: 16282288


  548. Slater M, Kiggundu M, Dokomajilar C, Kamya MR, Bakyaita N, Talisuna A, Rosenthal PJ, Dorsey G. Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy. Volume 73 of Issue 2. 2005. PMID: 16103584


  549. Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. Volume 2 of Issue 7. 2005. PMID: 16033307


  550. Parikh S, Gut J, Istvan E, Goldberg DE, Havlir DV, Rosenthal PJ. Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors. 2005. PMID: 15980379


  551. Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. 2005. PMID: 15964982


  552. Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ. Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. 2005. PMID: 15887974


  553. Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. 2005. PMID: 15809160


  554. Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F. Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda. Volume 72 of Issue 5. 2005. PMID: 15891132


  555. Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ. Synthesis and antimalarial activity of sulfonamide chalcone derivatives. 2005. PMID: 15848205


  556. Dahl EL, Rosenthal PJ. Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum. 2005. PMID: 15664655


  557. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. 2005. PMID: 15582423


  558. Rosenthal PJ. Cysteine proteases of malaria parasites. 2004. PMID: 15582526


  559. Parikh S, Dorsey G, Rosenthal PJ. Host polymorphisms and the incidence of malaria in Ugandan children. Volume 71 of Issue 6. 2004. PMID: 15642965


  560. Dorsey G, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR, Rosenthal PJ. Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. Volume 71 of Issue 6. 2004. PMID: 15642967


  561. Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ. Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Volume 364 of Issue 9449. 2004. PMID: 15567011


  562. Na BK, Kim TS, Rosenthal PJ, Lee JK, Kong Y. Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors. 2004. PMID: 15372231


  563. Go ML, Liu M, Wilairat P, Rosenthal PJ, Saliba KJ, Kirk K. Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes. 2004. PMID: 15328079


  564. Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts. 2004. PMID: 15225694


  565. Singh A, Rosenthal PJ. Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport. 2004. PMID: 15192087


  566. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. 2004. PMID: 15163200


  567. Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening. 2004. PMID: 15173840


  568. Sijwali PS, Kato K, Seydel KB, Gut J, Lehman J, Klemba M, Goldberg DE, Miller LH, Rosenthal PJ. Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. 2004. PMID: 15166288


  569. Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. 2004. PMID: 15181569


  570. Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ. Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Volume 9 of Issue 5. 2004. PMID: 15117308


  571. Sijwali PS, Rosenthal PJ. Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. 2004. PMID: 15070727


  572. Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ. Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax. 2004. PMID: 14629194


  573. Locher CP, Ruben PC, Gut J, Rosenthal PJ. 5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel. 2003. PMID: 14638487


  574. Lee BJ, Singh A, Chiang P, Kemp SJ, Goldman EA, Weinhouse MI, Vlasuk GP, Rosenthal PJ. Antimalarial activities of novel synthetic cysteine protease inhibitors. 2003. PMID: 14638488


  575. Boyom FF, Ngouana V, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ. Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. 2003. PMID: 14599525


  576. Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ. Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2. 2003. PMID: 14625277


  577. Rosenthal PJ. Antimalarial drug discovery: old and new approaches. 2003. PMID: 14506208


  578. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. 2003. PMID: 14505663


  579. Dorsey G, Vlahos J, Kamya MR, Staedke SG, Rosenthal PJ. Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria. Volume 188 of Issue 8. 2003. PMID: 14551894


  580. Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G. Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Volume 69 of Issue 3. 2003. PMID: 14628938


  581. Kyabayinze D, Cattamanchi A, Kamya MR, Rosenthal PJ, Dorsey G. Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria. Volume 69 of Issue 3. 2003. PMID: 14628939


  582. Batra S, Sabnis YA, Rosenthal PJ, Avery MA. Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines. 2003. PMID: 12713840


  583. Sabnis YA, Desai PV, Rosenthal PJ, Avery MA. Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies. 2003. PMID: 12592020


  584. Gasasira AF, Dorsey G, Nzarubara B, Staedke SG, Nassali A, Rosenthal PJ, Kamya MR. Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. 2003. PMID: 12641399


  585. Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Volume 68 of Issue 2. 2003. PMID: 12641400


  586. Shenai BR, Lee BJ, Alvarez-Hernandez A, Chong PY, Emal CD, Neitz RJ, Roush WR, Rosenthal PJ. Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones. 2003. PMID: 12499184


  587. Dorsey G, Njama D, Kamya MR, Cattamanchi A, Kyabayinze D, Staedke SG, Gasasira A, Rosenthal PJ. Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Volume 360 of Issue 9350. 2002. PMID: 12504399


  588. Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ. Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites. 2002. PMID: 12169096


  589. Shenai BR, Rosenthal PJ. Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases. 2002. PMID: 12076775


  590. Park BS, Kim DY, Rosenthal PJ, Huh SC, Lee BJ, Park E-, Kim SM, Kim JE, Kim MH, Huh TL, Choi YJ, Suh KH, Choi WS, Lee SE. Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen. 2002. PMID: 11992775


  591. Shenai BR, Semenov AV, Rosenthal PJ. Stage-specific antimalarial activity of cysteine protease inhibitors. 2002. PMID: 12108550


  592. Sabnis Y, Rosenthal PJ, Desai P, Avery MA. Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors. 2002. PMID: 11922834


  593. Rosenthal PJ. Hydrolysis of erythrocyte proteins by proteases of malaria parasites. 2002. PMID: 11844998


  594. Sijwali PS, Shenai BR, Rosenthal PJ. Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain. 2002. PMID: 11827964


  595. Rosenthal PJ, Sijwali PS, Singh A, Shenai BR. Cysteine proteases of malaria parasites: targets for chemotherapy. 2002. PMID: 12132997


  596. Sijwali PS, Shenai BR, Gut J, Singh A, Rosenthal PJ. Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. 2001. PMID: 11716777


  597. Joachimiak MP, Chang C, Rosenthal PJ, Cohen FE. The impact of whole genome sequence data on drug discovery--a malaria case study. 2001. PMID: 11713369


  598. Staedke SG, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, Rosenthal PJ. Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial. 2001. PMID: 11502317


  599. Sijwali PS, Brinen LS, Rosenthal PJ. Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2. 2001. PMID: 11388810


  600. Dorsey G, Kamya MR, Singh A, Rosenthal PJ. Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda. 2001. PMID: 11294677


  601. Singh A, Rosenthal PJ. Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum. 2001. PMID: 11181388


  602. Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Babirye JN, Staedke SG, Rosenthal PJ. The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. 2001. PMID: 11280066


  603. Shenai BR, Sijwali PS, Singh A, Rosenthal PJ. Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. 2000. PMID: 10887194


  604. Dorsey G, Gandhi M, Oyugi JH, Rosenthal PJ. Difficulties in the prevention, diagnosis, and treatment of imported malaria. 2000. PMID: 10979063


  605. Dorsey G, Kamya MR, Ndeezi G, Babirye JN, Phares CR, Olson JE, Katabira ET, Rosenthal PJ. Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda. 2000. PMID: 11304055


  606. Olson JE, Lee GK, Semenov A, Rosenthal PJ. Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors. 1999. PMID: 10353642


  607. Rosenthal PJ. Proteases of protozoan parasites. 1999. PMID: 10214691


  608. Rosenthal PJ, Semenov A, Ploplis VA, Plow EF. Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites. 1998. PMID: 9879906


  609. Semenov A, Olson JE, Rosenthal PJ. Antimalarial synergy of cysteine and aspartic protease inhibitors. 1998. PMID: 9736544


  610. Gor DO, Li AC, Wiser MF, Rosenthal PJ. Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases. 1998. PMID: 9763298


  611. Gor DO, Rosenthal PJ. Humoral immune responses of Africans to cysteine protease-related antigens of Plasmodium falciparum. 1998. PMID: 9652457


  612. Gor DO, Li AC, Rosenthal PJ. Protective immune responses against protease-like antigens of the murine malaria parasite Plasmodium vinckei. 1998. PMID: 9682379


  613. Rosenthal PJ. Proteases of malaria parasites: new targets for chemotherapy. 1998. PMID: 9452398


  614. Rosenthal PJ, Meshnick SR. Hemoglobin catabolism and iron utilization by malaria parasites. 1996. PMID: 9027746


  615. Rosenthal PJ, Olson JE, Lee GK, Palmer JT, Klaus JL, Rasnick D. Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. 1996. PMID: 8807047


  616. Gamboa de Domínguez ND, Rosenthal PJ. Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites. 1996. PMID: 8639807


  617. Rosenthal PJ. Conservation of key amino acids among the cysteine proteinases of multiple malarial species. 1996. PMID: 8992323


  618. Salas F, Fichmann J, Lee GK, Scott MD, Rosenthal PJ. Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase. 1995. PMID: 7768590


  619. Rosenthal PJ. Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites. 1995. PMID: 7895837


  620. Li Z, Chen X, Davidson E, Zwang O, Mendis C, Ring CS, Roush WR, Fegley G, Li R, Rosenthal PJ. Anti-malarial drug development using models of enzyme structure. 1994. PMID: 9383368


  621. Rosenthal PJ, Ring CS, Chen X, Cohen FE. Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases. 1994. PMID: 8057374


  622. Rosenthal PJ. A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue. 1993. PMID: 8485161


  623. Rosenthal PJ, Lee GK, Smith RE. Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. 1993. PMID: 8450035


  624. Rosenthal PJ, Nelson RG. Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum. 1992. PMID: 1565129


  625. Rosenthal PJ, Wollish WS, Palmer JT, Rasnick D. Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase. 1991. PMID: 1939639


  626. Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH. Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development. 1989. PMID: 2671722


  627. Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. 1988. PMID: 3053784


  628. Rosenthal PJ, Chaisson RE, Hadley WK, Leech JH. Rectal leishmaniasis in a patient with acquired immunodeficiency syndrome. 1988. PMID: 3407656


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