Lynn Pulliam, PhD

Professor

Dr. Pulliam is Professor of Laboratory Medicine and Medicine at UCSF. Her research interests are in HIV-associated cognitive impairment, neuroinflammation and chronic monocyte activation. She has begun to study how extracellular vesicles from activated cells can influence inflammation in recipient cells. Also, isolation of blood neuron-derived exosomes can be a window into the health of brain neurons and can be used as biomarkers for cognitive impairment in HIV, Alzheimer's and post COVID sequelae. She is former President and continuing Board of Directors Member of the Society for Neurovirology as well as a member of several journal Editorial Boards. Dr. Pulliam is Director of Microbiology at the San Francisco Veterans Affairs Medical Center where she teaches microbiology to Infectious Disease and Laboratory Medicine residents and fellows.

Education

Ph.D., 1983 - Graduate Division (Experimental Pathology), University of California, San Francisco

M.S., 1977 - Microbiology, California State University, Long Beach

BA, 1969 - Biology, Northwestern University, Evanston

Honors and Awards

Pioneer in Neurovirology, International Society for Neurovirology, 2019
Prize in Neurovirology, Drexel College of Medicine, 2017
Most Influential Women in Business, San Francisco Business Times, 2012
President, Society for Neurovirology, 2010-2013
Outstanding Women in Neuroscience, International Society for Neurovirology, 2009

Publications

Sun B, Tang N, Peluso MJ, Iyer NS, Torres L, Donatelli JL, Munter SE, Nixon CC, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Pulliam L. Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations. 2021. PMID: 33668514
Fernandes N, Pulliam L. Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV/AIDS. 2019. PMID: 31385260
Pulliam L, Liston M, Sun B, Narvid J. Using neuronal extracellular vesicles and machine learning to predict cognitive deficits in HIV. 2020. PMID: 32681213
Sun B, Abadjian L, Monto A, Freasier H, Pulliam L. Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms. 2020. PMID: 32157304
Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D. Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease. 2019. PMID: 30610738
Sun B, Dalvi P, Abadjian L, Tang N, Pulliam L. Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV. Volume 31 of Issue 14. 2017. PMID: 28692534
Dalvi P, Sun B, Tang N, Pulliam L. Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway. Volume 7 of Issue 1. 2017. PMID: 28855621
Tang N, Sun B, Gupta A, Rempel H, Pulliam L. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-?B in endothelial cells. Volume 30 of Issue 9. 2016. PMID: 27226520
Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. Human plasma platelet-derived exosomes: effects of aspirin. Volume 30 of Issue 5. 2016. PMID: 26873936
Pulliam L, Gupta A. Modulation of cellular function through immune-activated exosomes. Volume 34 of Issue 7. 2015. PMID: 25945690
Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H. Monocyte activation from interferon-a in HIV infection increases acetylated LDL uptake and ROS production. Volume 34 of Issue 10. 2014. PMID: 24731171
Gupta A, Pulliam L. Exosomes as mediators of neuroinflammation. 2014. PMID: 24694258
Pulliam L. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection. Volume 12 of Issue 2. 2014. PMID: 24862334
Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. Volume 8 of Issue 2. 2013. PMID: 23437063
Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. Volume 62 of Issue 2. 2013. PMID: 23187938
Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C. Global NeuroAIDS roundtable. Volume 19 of Issue 1. 2013. PMID: 23354550
Wang Q, Na B, Ou JH, Pulliam L, Yen TS. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. Volume 7 of Issue 5. 2012. PMID: 22606292
Pulliam L, Rempel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations. Volume 25 of Issue 14. 2011. PMID: 21750421
O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Volume 30 of Issue 2-3. 2011. PMID: 21508516
Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L. Suppressed monocyte gene expression profile in men versus women with PTSD. Volume 25 of Issue 3. 2010. PMID: 21145962
Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L. Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection. Volume 24 of Issue 10. 2010. PMID: 20495440
Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J, Pulliam L. Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy-treated subjects with human immunodeficiency virus type 1 infection. Volume 16 of Issue 2. 2010. PMID: 20307252
Hans Rempel, Bing Sun, Cyrus Calosing, Satish Pillai, Lynn Pulliam. Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection 2010. PMID:
Pulliam L. HIV regulation of amyloid beta production. Volume 4 of Issue 2. 2009. PMID: 19288202