B Joseph Guglielmo, PharmD

Dean, School of Pharmacy

B. Joseph Guglielmo, PharmD, is a pharmacist, clinical scientist, teacher, and international expert in the evidence-based use of antimicrobials to treat infections.

He was named dean of the UCSF School of Pharmacy in 2012 and holds the Troy C. Daniels Distinguished Professorship in Pharmaceutical Science.

As dean, Guglielmo oversees the activities and progress of three departments; a campus organized research unit; and a dean’s office charged with School administration and finance, strategic planning, communications, academic affairs, and the development and delivery of a doctor of pharmacy (PharmD) degree program. His leadership as dean actively supports the distinguishing UCSF concept of One UCSF and upholds the institution’s PRIDE values.

During his tenure as dean, the School of Pharmacy has remained the top recipient among pharmacy schools nationwide of research dollars from the National Institutes of Health (NIH), and its PharmD degree program has remained among the top-rated such programs in the nation.

Guglielmo initiated a transformation of the PharmD degree program, which welcomed its first class in 2018. The program’s foundation of scientific thinking evolves from the distinctive scientific mindset of the faculty, and the faculty’s drive to seek and apply new knowledge across research, education, and patient care.

Guglielmo is widely known as an advocate for therapeutics-related research, from basic science to health policy research. As chair of the School's Department of Clinical Pharmacy, Guglielmo oversaw a 40 percent increase in the Department of Clinical Pharmacy’s faculty research funding. He created the department-run Medication Outcomes Center in 2007 to improve medication use at UCSF Health and beyond. In the late 1980s he developed the UCSF Medical Center Antimicrobial Stewardship Program to ensure the safe, effective use of antimicrobials, focusing upon decreasing antimicrobial resistance. The program was one of the earliest programs of its kind in the United States.

As patients seek new and cost-effective health care with increasingly complicated disease states and medications, Guglielmo advocates for research on new ways for pharmacists to care for patients, especially in the community. He also supports strong relationships among clinical scientists and their upstream basic and translational scientist colleagues, as demonstrated through his own collaborations. Guglielmo has been actively involved in the UCSF Clinical and Translational Science Institute (CTSI) from its inception and during its renewal; he has also served as past associate director of the CTSI Mentor Development Program.

His personal research agenda involves the safe, effective, and appropriate use of antimicrobials, as well as the pharmacoepidemiology and pharmacokinetics of anti-infective agents. He is the author of numerous peer-reviewed papers, book chapters, and abstracts, the majority related to anti-infective agents.

He believes that the most important clinical research is shaped through the researcher’s own clinical experiences. Together with his administrative, research, and teaching responsibilities, he continues to be active as an infectious diseases pharmacist supporting the UCSF Medical Center Antimicrobial Stewardship Program and serving on the Infectious Diseases Consult Service team. These experiences continue to provide the background for important hypothesis-centered research on the safe, effective use of antimicrobials.

Beyond the hospital, Guglielmo developed clinical pharmacy services for UCSF HIV/AIDS programs, specifically for the HIV Women's Program and the Men of Color Program.

Guglielmo has taught doctor of pharmacy students, pharmacy residents and fellows, medical students and residents, and infectious diseases fellows for decades, and he has mentored infectious diseases specialty pharmacist residents and fellows continuously since 1986. He has also mentored a number of international scholars, including Fogarty fellows.

He is the recipient of many teaching awards, including the UCSF Lifetime Achievement in Mentoring Award, Resident Preceptor of the Year Awards, UCSF School of Pharmacy Long Teaching Awards, and UCSF Academic Senate Distinction in Teaching Award. He is a fellow of the American College Clinical Pharmacy and the Infectious Diseases Society of America.


Guglielmo earned a PharmD from the University of Southern California in 1978 and completed a PharmD residency at UCSF in 1979.
Education
Residency, 1979 - School of Pharmacy - Pharmacy Practice, University of California, San Francisco
PharmD, 1978 - Pharmacy, University of Southern California (USC)
B.S., 1973 - Biology, Santa Clara University
Honors and Awards
  • Fellow, Infectious Diseases Society America, 2013
  • Troy C. Daniels Distinguished Professorship in Pharmaceutical Science, UCSF, 2013
  • Fellow, American College of Clinical Pharmacy, 2011
  • Faculty Mentoring Program Lifetime Achievement in Mentoring Award, UCSF, 2010
  • Vincent G. Pons Award in Clinical Infectious Diseases, UCSF, 2005
  • Long Prize for Excellence in Teaching, UCSF, 1999
  • Pharmacy Leadership Society Recognition, Phi Lambda Sigma, 1995
  • Pharmacy Residents Preceptorship Award, UCSF, 1995
  • Fellow, California Society of Health-System Pharmacists, 1993
  • Academic Senate Distinction in Teaching Award, UCSF, 1992
  • Commencement Speaker, School of Pharmacy, UCSF, 1992
  • Pharmacy Residents Preceptorship Award, UCSF, 1989
  • Pharmacy Residents Preceptorship Award, UCSF, 1988
  • Pharmacy Residents Preceptorship Award, UCSF, 1987
  • Long Foundation Award for Excellence in Teaching, UCSF, 1986
  • Pharmacy Residents Preceptorship Award, UCSF, 1985
  • Long Foundation Award for Excellence in Teaching, UCSF, 1981
  • Pharmacy Residents Preceptorship Award, UCSF, 1981
Websites
Publications
  1. Guglielmo BJ. Metronidazole Neurotoxicity: Suspicions Confirmed. 2021. PMID: 32266372


  2. Guglielmo BJ. The Colchicine Debacle Revisited. 2021. PMID: 33252611


  3. Meyer-Massetti C, Hofstetter V, Hedinger-Grogg B, Meier CR, Guglielmo BJ. Medication-related problems during transfer from hospital to home care: baseline data from Switzerland. 2018. PMID: 30291577


  4. Meyer-Massetti C, Meier CR, Guglielmo BJ. The scope of drug-related problems in the home care setting. 2018. PMID: 29322475


  5. Roy SL, Atkins JT, Gennuso R, Kofos D, Sriram RR, Dorlo TP, Hayes T, Qvarnstrom Y, Kucerova Z, Guglielmo BJ, Visvesvara GS. Assessment of blood-brain barrier penetration of miltefosine used to treat a fatal case of granulomatous amebic encephalitis possibly caused by an unusual Balamuthia mandrillaris strain. 2015. PMID: 26329128


  6. Frymoyer A, Lee S, Bonifacio SL, Meng L, Lucas SS, Guglielmo BJ, Sun Y, Verotta D. Every 36-h gentamicin dosing in neonates with hypoxic-ischemic encephalopathy receiving hypothermia. 2013. PMID: 23702622


  7. Frymoyer A, Meng L, Bonifacio SL, Verotta D, Guglielmo BJ. Gentamicin pharmacokinetics and dosing in neonates with hypoxic ischemic encephalopathy receiving hypothermia. 2013. PMID: 23553582


  8. Burrell C, Tsourounis C, Quan D, Jue V, Tam E, Guglielmo BJ. Impact of a pharmacist-driven protocol to improve drug allergy documentation at a university hospital. 2013. PMID: 24421479


  9. Guglielmo BJ. The colchicine debacle. 2013. PMID: 23277277


  10. Cocohoba JM, Murphy P, Pietrandoni G, Guglielmo BJ. Improved antiretroviral refill adherence in HIV-focused community pharmacies. 2012. PMID: 23023860


  11. Murphy P, Cocohoba J, Tang A, Pietrandoni G, Hou J, Guglielmo BJ. Impact of HIV-specialized pharmacies on adherence and persistence with antiretroviral therapy. 2012. PMID: 22860900


  12. Swartling M, Gupta R, Dudas V, Guglielmo BJ. Short term impact of guidelines on vancomycin dosing and therapeutic drug monitoring. 2012. PMID: 22331444


  13. Cheng CM, Fu C, Guglielmo BJ, Auerbach AD. Boxed warning inconsistencies between drug information resources and the prescribing information. 2011. PMID: 21856808


  14. Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL. Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations. 2011. PMID: 21923588


  15. Guglielmo BJ, Edwards DJ, Franks AS, Naughton CA, Schonder KS, Stamm PL, Thornton P, Popovich NG. A critical appraisal of and recommendations for faculty development. 2011. PMID: 21931460


  16. Meyer-Massetti C, Vaerini S, Rätz Bravo AE, Meier CR, Guglielmo BJ. Comparative safety of antipsychotics in the WHO pharmacovigilance database: the haloperidol case. 2011. PMID: 21809143


  17. Meyer-Massetti C, Cheng CM, Schwappach DL, Paulsen L, Ide B, Meier CR, Guglielmo BJ. Systematic review of medication safety assessment methods. 2011. PMID: 21258028


  18. Macdougall C, Udkow T, Guglielmo BJ, Vittinghoff E, Martin J. National estimates and predictors of prescription medication sample use in the United States, 1999-2005. Volume 50 of Issue 6. 2010. PMID: 21071311


  19. Sohn AH, Schwartz JM, Yang KY, Jarvis WR, Guglielmo BJ, Weintrub PS. Risk factors and risk adjustment for surgical site infections in pediatric cardiothoracic surgery patients. 2010. PMID: 20605267


  20. Cheng CM, Guglielmo BJ, Maselli J, Auerbach AD. Coverage of FDA medication boxed warnings in commonly used drug information resources. 2010. PMID: 20458094


  21. Nakamura K, Schwartz BS, Lindegårdh N, Keh C, Guglielmo BJ. Possible neuropsychiatric reaction to high-dose oseltamivir during acute 2009 H1N1 influenza A infection. 2010. PMID: 20192728


  22. Meyer-Massetti C, Cheng CM, Sharpe BA, Meier CR, Guglielmo BJ. The FDA extended warning for intravenous haloperidol and torsades de pointes: how should institutions respond? 2010. PMID: 20394022


  23. Martin T, Sharma M, Damon L, Kaplan L, Guglielmo BJ, Working M, O'Malley R, Hwang J, Linker C. Voriconazole is safe and effective as prophylaxis for early and late fungal infections following allogeneic hematopoietic stem cell transplantation. 2009. PMID: 19793068


  24. Feldman MD, Huang L, Guglielmo BJ, Jordan R, Kahn J, Creasman JM, Wiener-Kronish JP, Lee KA, Tehrani A, Yaffe K, Brown JS. Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development Program. 2009. PMID: 19774102


  25. Marquez C, Guglielmo BJ, Klausner JD. Five years later: re-examining the financial burden of boosting with Norvir. 2008. PMID: 18981784


  26. Patel D, Lawson W, Guglielmo BJ. Antimicrobial stewardship programs: interventions and associated outcomes. 2008. PMID: 18380603


  27. Frenzel T, Lee CZ, Kim H, Quinnine NJ, Hashimoto T, Lawton MT, Guglielmo BJ, McCulloch CE, Young WL. Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance. 2008. PMID: 18212521


  28. Robinson CA, Cocohoba J, MacDougall C, John MD, Guglielmo BJ. Discordance between ambulatory care clinic and community pharmacy medication databases for HIV-positive patients. Volume 47 of Issue 5. 2007. PMID: 17848351


  29. Riedel A, Choe L, Inciardi J, Yuen C, Martin T, Guglielmo BJ. Antifungal prophylaxis in chemotherapy-associated neutropenia: a retrospective, observational study. 2007. PMID: 17605773


  30. Nicandro JP, Tsourounis C, Frassetto L, Guglielmo BJ. In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4. 2007. PMID: 17594986


  31. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. 2006. PMID: 16581945


  32. Deck DH, Guglielmo BJ. Pharmacological advances in the treatment of invasive candidiasis. 2006. PMID: 16441215


  33. Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL. Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. 2006. PMID: 16395286


  34. Guglielmo BJ, Dudas V, Maewal I, Young R, Hilts A, Villmann M, Gibbs L, Gropper M, Jacobs R. Impact of a series of interventions in vancomycin prescribing on use and prevalence of vancomycin-resistant enterococci. 2005. PMID: 16156195


  35. MacDougall C, Guglielmo BJ, Maselli J, Gonzales R. Antimicrobial drug prescribing for pneumonia in ambulatory care. Volume 11 of Issue 3. 2005. PMID: 15757551


  36. Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin M, Prusiner SB, Ryou C, Guglielmo BJ. Pharmacokinetics of quinacrine in the treatment of prion disease. 2004. PMID: 15569390


  37. MacDougall C, Guglielmo BJ. Pharmacokinetics of valaciclovir. Volume 53 of Issue 6. 2004. PMID: 15140857


  38. Oren E, Shaffer ER, Guglielmo BJ. Impact of emerging technologies on medication errors and adverse drug events. 2003. PMID: 12892029


  39. Hickman DE, Stebbins MR, Hanak JR, Guglielmo BJ. Pharmacy-based intervention to reduce antibiotic use for acute bronchitis. 2003. PMID: 12549944


  40. Yang K, Guglielmo BJ. Patient education for H pylori: who benefits? 2002. PMID: 11897729


  41. Graff LR, Franklin KK, Witt L, Cohen N, Jacobs RA, Tompkins L, Guglielmo BJ. Antimicrobial therapy of gram-negative bacteremia at two university-affiliated medical centers. 2002. PMID: 11893347


  42. Botwin KJ, Chan J, Jacobs R, Guglielmo BJ. Restricted access to automated dispensing machines for surgical antimicrobial prophylaxis. 2001. PMID: 11351920


  43. Burkiewicz JS, Kostiuk KA, Jacobs RA, Guglielmo BJ. Impact of an intravenous fluconazole restriction policy on patient outcomes. 2001. PMID: 11197590


  44. Guglielmo BJ, Luber AD, Paletta D, Jacobs RA. Ceftriaxone therapy for staphylococcal osteomyelitis: a review. 2000. PMID: 10619757


  45. Guglielmo BJ, Luber AD, Corelli RL, Flaherty JF, Jacobs RA. Prevention of adverse events in hospitalized patients using an antimicrobial review program. 1999. PMID: 10560287


  46. Luber AD, Maa L, Lam M, Guglielmo BJ. Risk factors for amphotericin B-induced nephrotoxicity. 1999. PMID: 11252333


  47. Wong-Beringer A, Jacobs RA, Guglielmo BJ. Lipid formulations of amphotericin B: clinical efficacy and toxicities. 1998. PMID: 9770163


  48. Guglielmo BJ, Kostiuk KA, Pons VG. Pharmacokinetics and pharmacodynamics of ceftizoxime in abscess fluid. 1997. PMID: 9096200


  49. Hashimoto S, Wolfe E, Guglielmo B, Shanks R, Sundelof J, Pittet JF, Thomas E, Wiener-Kronish J. Aerosolization of imipenem/cilastatin prevents pseudomonas-induced acute lung injury. 1996. PMID: 8961050


  50. Barlows TG, Luber AD, Jacobs RA, Guglielmo BJ. Hypothermia following the intravenous administration of amphotericin B. 1996. PMID: 8922832


  51. Tsourounis C, Guglielmo BJ. Aerosolized amphotericin B in prophylaxis of pulmonary aspergillosis. 1996. PMID: 8893125


  52. Wong-Beringer A, Corelli RL, Schrock TR, Guglielmo BJ. Influence of timing of antibiotic administration on tissue concentrations during surgery. 1995. PMID: 7694975


  53. Singh RF, Corelli RL, Guglielmo BJ. Sterility of unit dose syringes of filgrastim and sargramostim. 1994. PMID: 7531941


  54. Kostiuk KA, Pons VG, Guglielmo BJ. Penetration of fluconazole into abscess fluid. 1994. PMID: 7868415


  55. Guglielmo BJ, Wong-Beringer A, Linker CA. Immune globulin therapy in allogeneic bone marrow transplant: a critical review. 1994. PMID: 8054903


  56. Joe LA, Jacobs RA, Guglielmo BJ. Systemic absorption of oral fluconazole after gastrointestinal resection. 1994. PMID: 8089060


  57. Kanatani MS, Guglielmo BJ. The new macrolides. Azithromycin and clarithromycin. 1994. PMID: 8128699


  58. Wong-Beringer A, Jacobs RA, Guglielmo BJ. Nosocomial funguria: resultant morbidity and therapeutic intervention. 1993. PMID: 8110936


  59. Pons VG, Denlinger SL, Guglielmo BJ, Octavio J, Flaherty J, Derish PA, Wilson CB. Ceftizoxime versus vancomycin and gentamicin in neurosurgical prophylaxis: a randomized, prospective, blinded clinical study. 1993. PMID: 8413872


  60. Pons VG, Denlinger SL, Guglielmo BJ, Octavio J, Flaherty J, Derish PA, Wilson CB. Comment; ceftizoxime versus vancomycin and gentamicin in neurosurgical prophylaxis. 1993. PMID: 8413895


  61. Colford JM, Corelli RL, Ganz JW, Guglielmo BJ, Jacobs RA. Home antibiotic therapy for streptococcal endocarditis: a call for a controlled trial. 1993. PMID: 8420289


  62. Wong-Beringer A, Jacobs RA, Guglielmo BJ. Treatment of funguria. 1992. PMID: 1578598


  63. Glick PL, Guglielmo BJ, Winter ME, Finkbeiner W, Turley K. Iodine toxicity secondary to continuous povidone-iodine mediastinal irrigation in dogs. 1990. PMID: 2246887


  64. Glick M, Guglielmo BJ. Antibiotic prophylaxis in cesarean section. 1990. PMID: 2260343


  65. Hebert MF, Guglielmo BJ. What is the clinical role of aerosolized ribavirin? 1990. PMID: 2197815


  66. Guglielmo BJ, Brooks GF. Antimicrobial therapy. Cost-benefit considerations. 1989. PMID: 2510985


  67. Brodowy BA, Guglielmo BJ, York MK, Herfindal ET, Brooks GF. Experience with selective reporting of susceptibility to antimicrobial agents. 1989. PMID: 2801717


  68. Guglielmo BJ, Schweigert BF, Kishi DT. Pharmacist-managed drug therapy in California hospitals. 1989. PMID: 2757041


  69. Sue D, Salazar TA, Turley K, Guglielmo BJ. Effect of surgical blood loss and volume replacement on antibiotic pharmacokinetics. 1989. PMID: 2757440


  70. Guglielmo BJ, Jacobs RA, Locksley RM. The exposure of health care workers to ribavirin aerosol. 1989. PMID: 2926922


  71. Guglielmo BJ, Salazar TA, Rodondi LC, Carver M, Goldstone J, Stoney RJ. Altered pharmacokinetics of antibiotics during vascular surgery. 1989. PMID: 2929864


  72. Flaherty JF, Rodondi LC, Guglielmo BJ, Fleishaker JC, Townsend RJ, Gambertoglio JG. Comparative pharmacokinetics and serum inhibitory activity of clindamycin in different dosing regimens. 1988. PMID: 3245695


  73. Lam YW, Duroux MH, Gambertoglio JG, Barriere SL, Guglielmo BJ. Effect of protein binding on serum bactericidal activities of ceftazidime and cefoperazone in healthy volunteers. 1988. PMID: 3284457


  74. R.J. Harrison, J. Bellows, D. Rempel, L. Rudolph, K. Kizer, A. Jin, B.J. Guglielmo. Assessing Exposures of Health-care Personnel to Aerosols of Ribavirin-California 1988. PMID:


  75. Y.W.F. Lam, M.H. Duroux, J.G. Gambertoglio, S.L. Barriere, and B.J. Guglielmo. Effect of Protein Binding on Serum Bactericidal Activities of Ceftazidime and Cefoperazone in Healthy Volunteers 1988. PMID:


  76. M.J. Mahlmeister, B.J. Guglielmo, and R. Harrison. We are Concerned About Ribavirin Exposure 1988. PMID:


  77. Guglielmo BJ, Flaherty JF, Woods TM, LaFollette G, Gambertoglio JG. Pharmacokinetics of cefoperazone and tobramycin alone and in combination. 1987. PMID: 3566252


  78. B.J. Guglielmo, J.F. Flaherty, T.M. Woods, G. LaFollette, and J.G. Gambertoglio. Pharmacokinetics of Cefoperazone and Tobramycin Alone and in Combination 1987. PMID:


  79. Guglielmo BJ, Flaherty JF, Batman R, Barriere SL, Gambertoglio JG. Comparative pharmacokinetics of low- and high-dose ticarcillin. 1986. PMID: 3777901


  80. B.J. Guglielmo, J.F. Flaherty, R. Batman, S.L. Barriere, and J.G. Gambertoglio. Comparative Pharmacokinetics of Low- and High-Dose Ticarcillin 1986. PMID:


  81. Glick PL, Guglielmo BJ, Tranbaugh RF, Turley K. Iodine toxicity in a patient treated by continuous povidone-iodine mediastinal irrigation. 1985. PMID: 3994451


  82. P.L. Glick, B.J. Guglielmo, R.F. Tranbaugh, and K. Turley. Iodine Toxicity in a Patient Treated by Continuous Povidone-Iodine Mediastinal Irrigation 1985. PMID:


  83. B.J. Guglielmo, D.C. Hohn, P.J. Koo, T.K. Hunt, R.C. Sweet, and J.E. Conte. Antibiotic Prophylaxis in Surgical Procedures. A Critical Analysis of the Literature 1983. PMID:


  84. W.A. Kehoe and B.J. Guglielmo. Excessive Potassium Depletion with Metolazone and Furosemide 1983. PMID:


  85. B.D. Quart and B.J. Guglielmo. Prolonged Diarrhea Secondary to Methyldopa Therapy 1983. PMID:


  86. Brown KR, Guglielmo BJ, Pons VG, Jacobs RA. Theophylline elixir, moxalactam, and a disulfiram reaction. 1982. PMID: 6214982


  87. K.R. Brown, B.J. Guglielmo, V.G. Pons, and R.A. Jacobs. Theophylline Elixir, Moxalactam, and a Disulfiram Reaction 1982. PMID: