Andrew Kerkhoff, MD, PhD

Assistant Professor

Dr. Andew Kerkhoff is a physician-scientist and an Assistant Professor of Medicine in the Division of HIV, Infectious Diseases, and Global Medicine at Zuckerberg San Francisco General Hospital (ZSFG). His research has two main focuses: (1) He has more than a decade of experience evaluating novel tests and strategies to improve the diagnosis of tuberculosis (TB) in sub-Saharan Africa, with a focus on low-cost, point-of-care tools. (2) He also applies implementation science methods to improve individual- and population-level outcomes through the development, implementation, and evaluation of equity-focused, effective, scalable, and sustainable TB, HIV, and COVID-19 care engagement strategies in the United States and Zambia. Dr. Kerkhoff is an Associate Program Director for Curriculum for the UCSF Implementation Science Training Program and also serves as the Director of the UCSF CFAR Implementation Science Interest Group.
Education
Certificate, 2022 - Implementation Science, University of California, San Francisco
Fellowship, 2021 - Infectious Disease, University of California, San Francisco
Residency, 2017 - Internal Medicine, University of California, San Francisco
PhD, 2016 - Epidemiology, University of Amsterdam
MD, 2015 - Medicine, The George Washington University
MSc, 2010 - Control of Infectious Diseases, London School of Hygiene and Tropical Medicine
BA, 2008 - Music, The University of North Carolina at Chapel Hill
Honors and Awards
  • Stephen Lawn TB-HIV Research Leadership Prize, The Union/LSHTM TB Centre/University of Cape Town/The Lancet, 2023
  • HIV, Infectious Diseases and Global Health Implementation Research Institute Scholar, WUSTL, 2021-2023
  • Inter-CFAR Fellowship Program in Implementation Science for Early-Stage HIV Investigators, CFAR, 2020
  • CFAR Research Excellence Award in Clinical Science, UCSF, 2020
  • ZSFG Department of Medicine Clinical Fellow Award, UCSF, 2018
  • Young Investigator Award, CROI, 2013
  • Lazarus Scholarship in Health Care Delivery, GWU, 2012-2015
Websites
Publications

  3. Irie WC, Kerkhoff A, Kim HY, Geng E, Eshun-Wilson I. Using stated preference methods to facilitate knowledge translation in implementation science. 2024. PMID: 38549129


  4. Andrew D. Kerkhoff, Nora S. West, Maria del Mar Castro, David Branigan, Devasahayam J. Christopher, Claudia M. Denkinger, Nguyen Viet Nhung, Grant Theron, William Worodria, Charles Yu, Monde Muyoyeta, Adithya Cattamanchi. Placing the values and preferences of people most affected by TB at the center of screening and testing: an approach for reaching the unreached. 2023. PMID:


  5. Aschmann HE, Musinguzi A, Kadota JL, Namale C, Kakeeto J, Nakimuli J, Akello L, Welishe F, Nakitende A, Berger C, Dowdy DW, Cattamanchi A, Semitala FC, Kerkhoff AD. Preferences of people living with HIV for features of tuberculosis preventive treatment regimens - a discrete choice experiment. 2023. PMID: 37745521


  6. Faust L, Naidoo P, Caceres-Cardenas G, Ugarte-Gil C, Muyoyeta M, Kerkhoff AD, Nagarajan K, Satyanarayana S, Rakotosamimanana N, Grandjean Lapierre S, Adejumo OA, Kuye J, Oga-Omenka C, Pai M, Subbaraman R. Improving measurement of tuberculosis care cascades to enhance people-centred care. 2023. PMID: 37652066


  7. Kagujje M, Nyangu S, Maimbolwa MM, Shuma B, Mutti L, Somwe P, Sanjase N, Chungu C, Kerkhoff AD, Muyoyeta M. Strategies to increase childhood tuberculosis case detection at the primary health care level: Lessons from an active case finding study in Zambia. 2023. PMID: 37467209


  9. Kerkhoff AD, Mwamba C, Pry JM, Kagujje M, Nyangu S, Mateyo K, Sanjase N, Chilukutu L, Christopoulos KA, Muyoyeta M, Sharma A. A mixed methods study on men's and women's tuberculosis care journeys in Lusaka, Zambia-Implications for gender-tailored tuberculosis health promotion and case finding strategies. 2023. PMID: 37327200


  10. Dhana A, Gupta RK, Hamada Y, Kengne AP, Kerkhoff AD, Yoon C, Cattamanchi A, Reeve BWP, Theron G, Ndlangalavu G, Wood R, Drain PK, Calderwood CJ, Noursadeghi M, Boyles T, Meintjes G, Maartens G, Barr DA. Clinical utility of WHO-recommended screening tools and development and validation of novel clinical prediction models for pulmonary tuberculosis screening among outpatients living with HIV: an individual participant data meta-analysis. 2023. PMID: 37286216


  11. Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, Blanc FX, Esmail A, Reeve BWP, Floridia M, Kerkhoff AD, Ciccacci F, Kasaro MP, Thit SS, Bastard M, Ferlazzo G, Yoon C, Van Hoving DJ, Sossen B, García JI, Cummings MJ, Wake RM, Hanson J, Cattamanchi A, Meintjes G, Maartens G, Wood R, Theron G, Dheda K, Olaru ID, Denkinger CM, TBYield Study Consortium. Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data. 2023. PMID: 37202025


  14. Marquez C, Kerkhoff AD, Schrom J, Rojas S, Black D, Mitchell A, Wang CY, Pilarowski G, Ribeiro S, Jones D, Payan J, Manganelli S, Rojas S, Lemus J, Jain V, Chamie G, Tulier-Laiwa V, Petersen M, DeRisi J, Havlir DV. COVID-19 Symptoms and Duration of Rapid Antigen Test Positivity at a Community Testing and Surveillance Site During Pre-Delta, Delta, and Omicron BA.1 Periods. 2022. PMID: 36215069


  16. Lungu PS, Kabaso ME, Mihova R, Silumesii A, Chisenga T, Kasapo C, Mwaba I, Kerkhoff AD, Muyoyeta M, Chimzizi R, Malama K. Undernotification and underreporting of tuberculosis in Zambia: a national data quality assessment. 2022. PMID: 35996175


  17. Kerkhoff AD, Chilukutu L, Nyangu S, Kagujje M, Mateyo K, Sanjase N, Eshun-Wilson I, Geng EH, Havlir DV, Muyoyeta M. Patient Preferences for Strategies to Improve Tuberculosis Diagnostic Services in Zambia. 2022. PMID: 36036933


  18. Imbert E, Hickey MD, Del Rosario JB, Conte M, Kerkoff AD, Clemenzi-Allen A, Riley ED, Havlir DV, Gandhi M. Heterogeneous preferences for care engagement among people with HIV experiencing homelessness or unstable housing during the COVID-19 pandemic. 2022. PMID: 35262529


  19. Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Broger T, Denkinger CM, Rangaka MX, Gupta-Wright A, Fielding K, Wood R, Huerga H, Rucker SCM, Bjerrum S, Johansen IS, Thit SS, Kyi MM, Hanson J, Barr DA, Meintjes G, Maartens G. Diagnostic accuracy of WHO screening criteria to guide lateral-flow lipoarabinomannan testing among HIV-positive inpatients: a systematic review and individual participant data meta-analysis. 2022. PMID: 35588942


  20. Kerkhoff AD, Rojas S, Black D, Ribeiro S, Rojas S, Valencia R, Lemus J, Payan J, Schrom J, Jones D, Manganelli S, Bandi S, Chamie G, Tulier-Laiwa V, Petersen M, Havlir D, Marquez C. Integrating Rapid Diabetes Screening Into a Latinx Focused Community-Based Low-Barrier COVID-19 Testing Program. 2022. PMID: 35616939


  21. Jake M. Pry, Michael J. Vinikoor, Carolyn Bolton Moore, Monika Roy, Aaloke Mody, Izukanji Sikazwe, Anjali Sharma, Belinda Chihota, Miquel Duran-Frigola, Harriet Daultrey, Jacob Mutale, Andrew D. Kerkhoff, Elvin H. Geng, Brad H. Pollock, Jaime H. Vera. Evaluation of kidney function among people living with HIV initiating antiretroviral therapy in Zambia. 2022. PMID:


  22. Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Gupta-Wright A, Fielding K, Wood R, Huerga H, Rücker SCM, Heidebrecht C, Wilson D, Bjerrum S, Johansen IS, Thit SS, Kyi MM, Hanson J, Barr DA, Meintjes G, Maartens G. Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis. 2022. PMID: 35338834


  23. Chilukutu L, Mwanza W, Kerkhoff AD, Somwe P, Kagujje M, Muyoyeta M. Prevalence and interpretation of Xpert® Ultra trace results among presumptive TB patients. 2022. PMID: 35317531


  24. Kerkhoff AD, Farrand E, Marquez C, Cattamanchi A, Handley MA. Addressing health disparities through implementation science-a need to integrate an equity lens from the outset. 2022. PMID: 35101088


  26. Lungu PS, Kerkhoff AD, Muyoyeta M, Kasapo CC, Nyangu S, Kagujje M, Chimzizi R, Nyimbili S, Khunga M, Kasese-Chanda N, Musonda V, Tambatamba B, Kombe CM, Sakulanda C, Sampa K, Silumesii A, Malama K. Interrupted time-series analysis of active case-finding for tuberculosis during the COVID-19 pandemic, Zambia. 2022. PMID: 35261409


  27. Pry JM, Sikombe K, Mody A, Iyer S, Mutale J, Vlahakis N, Savory T, Wa Mwanza M, Mweebo K, Mwila A, Mwale C, Mukumbwa-Mwenechanya M, Kerkhoff AD, Sikazwe I, Bolton Moore C, Mwamba D, Geng EH, Herce ME. Mitigating the effects of COVID-19 on HIV treatment and care in Lusaka, Zambia: a before-after cohort study using mixed effects regression. 2022. PMID: 35078810


  29. Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Singh S, Hanifa Y, Grant AD, Fielding K, Affolabi D, Merle CS, Wachinou AP, Yoon C, Cattamanchi A, Hoffmann CJ, Martinson N, Mbu ET, Sander MS, Balcha TT, Skogmar S, Reeve BWP, Theron G, Ndlangalavu G, Modi S, Cavanaugh J, Swindells S, Chaisson RE, Ahmad Khan F, Howard AA, Wood R, Thit SS, Kyi MM, Hanson J, Drain PK, Shapiro AE, Kufa T, Churchyard G, Nguyen DT, Graviss EA, Bjerrum S, Johansen IS, Gersh JK, Horne DJ, LaCourse SM, Al-Darraji HAA, Kamarulzaman A, Kempker RR, Tukvadze N, Barr DA, Meintjes G, Maartens G. Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis. 2021. PMID: 34800394


  31. Reddy KP, Denkinger CM, Broger T, McCann NC, Gupta-Wright A, Kerkhoff AD, Pei PP, Shebl FM, Fielding KL, Nicol MP, Horsburgh CR, Meintjes G, Freedberg KA, Wood R, Walensky RP. Cost-effectiveness of a Novel Lipoarabinomannan Test for Tuberculosis in Patients With Human Immunodeficiency Virus. 2021. PMID: 33200169


  32. Cobelens F, Kerkhoff AD. Tuberculosis and anemia-cause or effect? 2021. PMID: 34548015


  33. Marquez C, Kerkhoff AD, Naso J, Contreras MG, Castellanos Diaz E, Rojas S, Peng J, Rubio L, Jones D, Jacobo J, Rojas S, Gonzalez R, Fuchs JD, Black D, Ribeiro S, Nossokoff J, Tulier-Laiwa V, Martinez J, Chamie G, Pilarowski G, DeRisi J, Petersen M, Havlir DV. A multi-component, community-based strategy to facilitate COVID-19 vaccine uptake among Latinx populations: From theory to practice. 2021. PMID: 34543291


  34. Auld AF, Kerkhoff AD, Hanifa Y, Wood R, Charalambous S, Liu Y, Agizew T, Mathoma A, Boyd R, Date A, Shiraishi RW, Bicego G, Mathebula-Modongo U, Alexander H, Serumola C, Rankgoane-Pono G, Pono P, Finlay A, Shepherd JC, Ellerbrock TV, Grant AD, Fielding K. Derivation and external validation of a risk score for predicting HIV-associated tuberculosis to support case finding and preventive therapy scale-up: A cohort study. 2021. PMID: 34491987


  35. Kerkhoff AD, Cattamanchi A, Muyoyeta M, Denkinger CM, Dowdy DW. Validating novel diagnostic assays for tuberculosis in the context of existing tools. 2021. PMID: 34416206


  36. Kerkhoff AD, Kagujje M, Nyangu S, Mateyo K, Sanjase N, Chilukutu L, Eshun-Wilson I, Geng EH, Havlir DV, Muyoyeta M. Pathways to care and preferences for improving tuberculosis services among tuberculosis patients in Zambia: A discrete choice experiment. 2021. PMID: 34464392


  37. Lungu P, Kerkhoff AD, Kasapo CC, Mzyece J, Nyimbili S, Chimzizi R, Silumesii A, Kagujje M, Subbaraman R, Muyoyeta M, Malama K. Tuberculosis care cascade in Zambia - identifying the gaps in order to improve outcomes: a population-based analysis. 2021. PMID: 34376439


  38. Chamie G, Marquez C, Crawford E, Peng J, Petersen M, Schwab D, Schwab J, Martinez J, Es DJ, Black D, Gandhi M, Kerkhoff AD, Jain V, Sergi F, Jacobo J, Rojas S, Tulier-Laiwa V, Gallardo-Brown T, Appa A, Chiu C, Rodgers M, Hackett J, Kistler A, Hao S, Kamm J, Dynerman D, Batson J, Greenhouse B, DeRisi J, Havlir DV. SARS-CoV-2 Community Transmission disproportionately affects Latinx population during Shelter-in-Place in San Francisco. 2020. PMID: 32821935


  40. Mwamba C, Kerkhoff AD, Kagujje M, Lungu P, Muyoyeta M, Sharma A. Diagnosed with TB in the era of COVID-19: patient perspectives in Zambia. 2020. PMID: 33437679


  41. Sossen B, Broger T, Kerkhoff AD, Schutz C, Trollip A, Moreau E, Schumacher SG, Burton R, Ward A, Wilkinson RJ, Barr DA, Nicol MP, Denkinger CM, Meintjes G. "SILVAMP TB LAM" Rapid Urine Tuberculosis Test Predicts Mortality in Patients Hospitalized With Human Immunodeficiency Virus in South Africa. 2020. PMID: 31917832


  42. Kerkhoff AD, Sachdev D, Mizany S, Rojas S, Gandhi M, Peng J, Black D, Jones D, Rojas S, Jacobo J, Tulier-Laiwa V, Petersen M, Martinez J, Chamie G, Havlir DV, Marquez C. Evaluation of a novel community-based COVID-19 'Test-to-Care' model for low-income populations. 2020. PMID: 33035216


  44. Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Kangelaris KN, Langelier C, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G. Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19. 2020. PMID: 32864588


  45. Kerkhoff AD, Longley N, Kelly N, Cross A, Vogt M, Wood R, Hermans S, Lawn SD, Harrison TS. Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa. 2020. PMID: 32736601


  46. Kerkhoff AD, Havlir DV. Virtual CROI 2020: Tuberculosis and Coinfections In HIV Infection. 2020. PMID: 32886465


  47. Kerkhoff AD, Sikombe K, Eshun-Wilson I, Sikazwe I, Glidden DV, Pry JM, Somwe P, Beres LK, Simbeza S, Mwamba C, Bukankala C, Hantuba C, Moore CB, Holmes CB, Padian N, Geng EH. Mortality estimates by age and sex among persons living with HIV after ART initiation in Zambia using electronic medical records supplemented with tracing a sample of lost patients: A cohort study. 2020. PMID: 32401797


  48. Broger T, Nicol MP, Székely R, Bjerrum S, Sossen B, Schutz C, Opintan JA, Johansen IS, Mitarai S, Chikamatsu K, Kerkhoff AD, Macé A, Ongarello S, Meintjes G, Denkinger CM, Schumacher SG. Diagnostic accuracy of a novel tuberculosis point-of-care urine lipoarabinomannan assay for people living with HIV: A meta-analysis of individual in- and outpatient data. 2020. PMID: 32357197


  49. Budak JZ, Brickman CE, Abdoler EA, Wallender EK, Mulliken JS, Kerkhoff AD, Lampiris H, Babik JM, Koss CA, Schwartz BS. Response to: Is Burnout Infectious? Understanding Drivers of Burnout and Job Satisfaction Among Academic Infectious Diseases Physicians. 2020. PMID: 32284950


  50. Kerkhoff AD, Muyoyeta M, Cattamanchi A. Community-wide Screening for Tuberculosis. 2020. PMID: 32187484


  51. Barr DA, Lewis JM, Feasey N, Schutz C, Kerkhoff AD, Jacob ST, Andrews B, Kelly P, Lakhi S, Muchemwa L, Bacha HA, Hadad DJ, Bedell R, van Lettow M, Zachariah R, Crump JA, Alland D, Corbett EL, Gopinath K, Singh S, Griesel R, Maartens G, Mendelson M, Ward AM, Parry CM, Talbot EA, Munseri P, Dorman SE, Martinson N, Shah M, Cain K, Heilig CM, Varma JK, von Gottberg A, Sacks L, Wilson D, Squire SB, Lalloo DG, Davies G, Meintjes G. Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data. 2020. PMID: 32178764


  52. Kerkhoff AD, Sossen B, Schutz C, Reipold EI, Trollip A, Moreau E, Schumacher SG, Burton R, Ward A, Nicol MP, Meintjes G, Denkinger CM, Broger T. Diagnostic sensitivity of SILVAMP TB-LAM (FujiLAM) point-of-care urine assay for extra-pulmonary tuberculosis in people living with HIV. 2020. PMID: 31699835


  53. Broger T, Muyoyeta M, Kerkhoff AD, Denkinger CM, Moreau E. Tuberculosis test results using fresh versus biobanked urine samples with FujiLAM. 2020. PMID: 31876492


  54. Kerkhoff AD, Cattamanchi A. HIV and Tuberculosis: A Formidable Alliance 2019. PMID:


  55. Schutz C, Ward A, Burton R, Nicol MP, Blumenthal L, Meintjes G, Kerkhoff AD. False rifampicin resistant results using Xpert MTB/RIF on urine samples in hospitalised HIV-infected patients. 2019. PMID: 31534789


  56. Broger T, Sossen B, du Toit E, Kerkhoff AD, Schutz C, Ivanova Reipold E, Ward A, Barr DA, Macé A, Trollip A, Burton R, Ongarello S, Pinter A, Lowary TL, Boehme C, Nicol MP, Meintjes G, Denkinger CM. Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study. 2019. PMID: 31155318


  57. Barr DA, Kerkhoff AD, Schutz C, Ward AM, Davies GR, Wilkinson RJ, Meintjes G. HIV-Associated Mycobacterium tuberculosis Bloodstream Infection Is Underdiagnosed by Single Blood Culture. 2018. PMID: 29444831


  58. Gupta-Wright A, Kerkhoff AD, Meintjes G, Corbett EL. Urinary Lipoarabinomannan Detection and Disseminated Nontuberculous Mycobacterial Disease. 2018. PMID: 29020175


  59. Kerkhoff AD, Patrick L, Cornett P, Kleinhenz ME, Brondfield S. Severe piperacillin-tazobactam-induced hemolysis in a cystic fibrosis patient. 2017. PMID: 29225856


  63. Kerkhoff AD, Meintjes G, Opie J, Vogt M, Jhilmeet N, Wood R, Lawn SD. Anaemia in patients with HIV-associated TB: relative contributions of anaemia of chronic disease and iron deficiency. 2016. PMID: 26792471


  64. Meintjes G, Kerkhoff AD, Burton R, Schutz C, Boulle A, Van Wyk G, Blumenthal L, Nicol MP, Lawn SD. HIV-Related Medical Admissions to a South African District Hospital Remain Frequent Despite Effective Antiretroviral Therapy Scale-Up. 2015. PMID: 26683950


  73. Kerkhoff AD, Reyes JA, Robert AD, Simon GL.. A Rare Complication of Cytomegalovirus Infection 2014. PMID:


  84. Kerkhoff AD, Kranzer K, Samandari T, Nakiyingi-Miiro J, Whalen CC, Harries AD, Lawn SD. Systematic review of TST responses in people living with HIV in under-resourced settings: implications for isoniazid preventive therapy. 2012. PMID: 23209621


  89. Lawn SD, Kerkhoff AD, Wood R. Reply to Theron et al 2012. PMID:


  96. Foster RD, Solberg TD, Li HS, Kerkhoff A, Enke CA, Willoughby TR, Kupelian PA. Comparison of transabdominal ultrasound and electromagnetic transponders for prostate localization. 2010. PMID: 20160686