Paul Sullam, MD

Professor

Education
Clinical Fellowship, 1985 - Infectious Diseases, University of California, San Francisco
Residency, 1981 - Internal Medicine, Cedars Sinai-UCLA
M.D., 1978 - Medicine, University of Chicago, Pritzker School of Medicine
A.B., 1974 - Biology, University of Chicago
Publications
  1. KeAndreya Morrison, Barbara Bensing, Hai Yu, Xi Chen, Paul Sullam, T. Iverson. Abstract 1982 Targeting Sialic Acids with Streptococcal Adhesin Proteins. 2024. PMID:


  2. Srivastava S, Verhagen A, Sasmal A, Wasik BR, Diaz S, Yu H, Bensing BA, Khan N, Khedri Z, Secrest P, Sullam P, Varki N, Chen X, Parrish CR, Varki A. Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome. 2022. PMID: 35926090


  3. Bensing BA, Stubbs HE, Agarwal R, Yamakawa I, Luong K, Solakyildirim K, Yu H, Hadadianpour A, Castro MA, Fialkowski KP, Morrison KM, Wawrzak Z, Chen X, Lebrilla CB, Baudry J, Smith JC, Sullam PM, Iverson TM. Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation. 2022. PMID: 35585145


  4. Solakyildirim K, Li Y, Bayer AS, Sullam PM, Xiong YQ, Lebrilla CB, Bensing BA. Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis. 2021. PMID: 34459483


  5. Nason R, Büll C, Konstantinidi A, Sun L, Ye Z, Halim A, Du W, Sørensen DM, Durbesson F, Furukawa S, Mandel U, Joshi HJ, Dworkin LA, Hansen L, David L, Iverson TM, Bensing BA, Sullam PM, Varki A, Vries E, de Haan CAM, Vincentelli R, Henrissat B, Vakhrushev SY, Clausen H, Narimatsu Y. Display of the human mucinome with defined O-glycans by gene engineered cells. 2021. PMID: 34210959


  6. Ji HJ, Zhi Y, Lee JH, Ahn KB, Seo HS, Sullam PM. Inhibition of Fibrinolysis by Streptococcal Phage LysinSM1. 2021. PMID: 34154404


  7. Seepersaud R, Anderson AC, Bensing BA, Choudhury BP, Clarke AJ, Sullam PM. O-acetylation controls the glycosylation of bacterial serine-rich repeat glycoproteins. 2020. PMID: 33384382


  8. Stubbs HE, Bensing BA, Yamakawa I, Sharma P, Yu H, Chen X, Sullam PM, Iverson TM. Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects. 2020. PMID: 32820052


  9. Miriam Braunstein, Barbara A. Bensing, Paul M. Sullam. The Two Distinct Types of SecA2-Dependent Export Systems. 2019. PMID:


  10. Bensing BA, Li L, Yakovenko O, Wong M, Barnard KN, Iverson TM, Lebrilla CB, Parrish CR, Thomas WE, Xiong Y, Sullam PM. Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection. 2019. PMID: 31233555


  11. Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H. An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells. 2019. PMID: 31227230


  12. Kebriaei R, Rice SA, Stamper KC, Seepersaud R, Garcia-de-la-Maria C, Mishra NN, Miro JM, Arias CA, Tran TT, Sullam PM, Bayer AS, Rybak MJ. Daptomycin Dose-Ranging Evaluation with Single-Dose versus Multidose Ceftriaxone Combinations against Streptococcus mitis/oralis in an Ex Vivo Simulated Endocarditis Vegetation Model. 2019. PMID: 30962347


  13. Saurabh Srivastava, Andrea Verhagen, Brian Wasik, Hai Yu, Aniruddha Sasmal, Barbara Bensing, Naazneen Khan, Zahra Khedri, Sandra Diaz, Paul Sullam, Nissi Varki, Xi Chen, Colin Parrish, Ajit Varki. Development of Sialoglycan Recognizing Probes (SGRPs) With Defined Specificities: Towards Exploring the Dynamic Mammalian Sialoglycome. 2019. PMID:


  14. Braunstein M, Bensing BA, Sullam PM. The Two Distinct Types of SecA2-Dependent Export Systems. 2019. PMID: 31215505


  15. Tran TT, Mishra NN, Seepersaud R, Diaz L, Rios R, Dinh AQ, Garcia-de-la-Maria C, Rybak MJ, Miro JM, Shelburne S, Sullam PM, Bayer AS, Arias CA. Mutations in cdsA and pgsA Correlate With Daptomycin Resistance in S. mitis/oralis. 2018. PMID: 30509945


  16. Spencer C, Bensing BA, Mishra NN, Sullam PM. Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery. 2018. PMID: 30514759


  17. Razieh Kebriaei, Seth Rice, Kyle Stamper, Cristina Garcia-De-La-Maria, Nagendra Mishra, Jose M Miro, Cesar Arias, Truc Tran, Paul Sullam, Arnold Bayer, Michael J Rybak. 1403. Daptomycin Combined with Low Dose Ceftriaxone Prevents the Emergence of Daptomycin Resistance against Streptococcus mitis-oralis Group in an In vitro Model of Simulated Endocardial Vegetations (SEVs). 2018. PMID:


  18. Yakovenko O, Nunez J, Bensing B, Yu H, Mount J, Zeng J, Hawkins J, Chen X, Sullam PM, Thomas W. SRR Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets. 2018. PMID: 29581195


  19. Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA. Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. 2018. PMID: 29462788


  20. Lin SM, Jang AY, Zhi Y, Gao S, Lim S, Lim JH, Song JY, Sullam PM, Rhee JH, Seo HS. Vaccination With a Latch Peptide Provides Serotype-Independent Protection Against Group B Streptococcus Infection in Mice. Volume 217 of Issue 1. 2017. PMID: 29106586


  21. Seepersaud R, Sychantha D, Bensing BA, Clarke AJ, Sullam PM. O-acetylation of the serine-rich repeat glycoprotein GspB is coordinated with accessory Sec transport. Volume 13 of Issue 8. 2017. PMID: 28827841


  22. Yim J, Smith JR, Singh NB, Rice S, Stamper K, Garcia de la Maria C, Bayer AS, Mishra NN, Miró JM, Tran TT, Arias CA, Sullam P, Rybak MJ. Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs). Volume 72 of Issue 8. 2017. PMID: 28475731


  23. Garcia-de-la-Maria C, Xiong YQ, Pericas JM, Armero Y, Moreno A, Mishra NN, Rybak MJ, Tran TT, Arias CA, Sullam PM, Bayer AS, Miro JM. Impact of High-Level Daptomycin Resistance in the Streptococcus mitis Group on Virulence and Survivability during Daptomycin Treatment in Experimental Infective Endocarditis. 2017. PMID: 28264848


  24. Mishra NN, Tran TT, Seepersaud R, Garcia-de-la-Maria C, Faull K, Yoon A, Proctor R, Miro JM, Rybak MJ, Bayer AS, Arias CA, Sullam PM. Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism. Volume 61 of Issue 4. 2017. PMID: 28115347


  25. Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam PM, Iverson TM. Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. 2016. PMID: 27685666


  26. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Volume 26 of Issue 11. 2016. PMID: 27037304


  27. Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA. Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Volume 113 of Issue 9. 2016. PMID: 26884191


  28. Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM. Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. Volume 291 of Issue 14. 2016. PMID: 26833566


  29. Deng L, Bensing BA, Thamadilok S, Yu H, Lau K, Chen X, Ruhl S, Sullam PM, Varki A. Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood. Volume 10 of Issue 12. 2014. PMID: 25474103


  30. Wang NY, Patras KA, Seo HS, Cavaco CK, Rösler B, Neely MN, Sullam PM, Doran KS. Group B streptococcal serine-rich repeat proteins promote interaction with fibrinogen and vaginal colonization. Volume 210 of Issue 6. 2014. PMID: 24620021


  31. Bensing BA, Seepersaud R, Yen YT, Sullam PM. Selective transport by SecA2: an expanding family of customized motor proteins. Volume 1843 of Issue 8. 2013. PMID: 24184206


  32. Seo HS, Minasov G, Seepersaud R, Doran KS, Dubrovska I, Shuvalova L, Anderson WF, Iverson TM, Sullam PM. Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae. Volume 288 of Issue 50. 2013. PMID: 24165132


  33. Yen YT, Cameron TA, Bensing BA, Seepersaud R, Zambryski PC, Sullam PM. Differential localization of the streptococcal accessory sec components and implications for substrate export. Volume 195 of Issue 4. 2012. PMID: 23204472


  34. Seepersaud R, Bensing BA, Yen YT, Sullam PM. The accessory Sec protein Asp2 modulates GlcNAc deposition onto the serine-rich repeat glycoprotein GspB. Volume 194 of Issue 20. 2012. PMID: 22885294


  35. Baum PD, Sullam PM, Stoddart CA, McCune JM. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. Volume 25 of Issue 18. 2011. PMID: 21941165


  36. Pyburn TM, Bensing BA, Xiong YQ, Melancon BJ, Tomasiak TM, Ward NJ, Yankovskaya V, Oliver KM, Cecchini G, Sulikowski GA, Tyska MJ, Sullam PM, Iverson TM. A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. Volume 7 of Issue 7. 2011. PMID: 21765814


  37. Yen YT, Seepersaud R, Bensing BA, Sullam PM. Asp2 and Asp3 interact directly with GspB, the export substrate of the Streptococcus gordonii accessory Sec System. Volume 193 of Issue 13. 2011. PMID: 21531800


  38. Nallapareddy SR, Sillanpää J, Mitchell J, Singh KV, Chowdhury SA, Weinstock GM, Sullam PM, Murray BE. Conservation of Ebp-type pilus genes among Enterococci and demonstration of their role in adherence of Enterococcus faecalis to human platelets. Volume 79 of Issue 7. 2011. PMID: 21502588


  39. Pyburn TM, Yankovskaya V, Bensing BA, Cecchini G, Sullam PM, Iverson TM. Purification, crystallization and preliminary X-ray diffraction analysis of the carbohydrate-binding region of the Streptococcus gordonii adhesin GspB. Volume 66 of Issue Pt 11. 2010. PMID: 21045307


  40. Seepersaud R, Bensing BA, Yen YT, Sullam PM. Asp3 mediates multiple protein-protein interactions within the accessory Sec system of Streptococcus gordonii. Volume 78 of Issue 2. 2010. PMID: 20807195


  41. Seo HS, Xiong YQ, Mitchell J, Seepersaud R, Bayer AS, Sullam PM. Bacteriophage lysin mediates the binding of streptococcus mitis to human platelets through interaction with fibrinogen. Volume 6 of Issue 8. 2010. PMID: 20714354


  42. Sanchez CJ, Shivshankar P, Stol K, Trakhtenbroit S, Sullam PM, Sauer K, Hermans PW, Orihuela CJ. The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms. Volume 6 of Issue 8. 2010. PMID: 20714350


  43. Miragaia M, de Lencastre H, Perdreau-Remington F, Chambers HF, Higashi J, Sullam PM, Lin J, Wong KI, King KA, Otto M, Sensabaugh GF, Diep BA. Genetic diversity of arginine catabolic mobile element in Staphylococcus epidermidis. Volume 4 of Issue 11. 2009. PMID: 19893740


  44. van Sorge NM, Quach D, Gurney MA, Sullam PM, Nizet V, Doran KS. The group B streptococcal serine-rich repeat 1 glycoprotein mediates penetration of the blood-brain barrier. Volume 199 of Issue 10. 2009. PMID: 19392623


  45. Bensing BA, Sullam PM. Characterization of Streptococcus gordonii SecA2 as a paralogue of SecA. Volume 191 of Issue 11. 2009. PMID: 19363114


  46. Siboo IR, Chaffin DO, Rubens CE, Sullam PM. Characterization of the accessory Sec system of Staphylococcus aureus. Volume 190 of Issue 18. 2008. PMID: 18621893


  47. Xiong YQ, Bensing BA, Bayer AS, Chambers HF, Sullam PM. Role of the serine-rich surface glycoprotein GspB of Streptococcus gordonii in the pathogenesis of infective endocarditis. Volume 45 of Issue 4. 2008. PMID: 18656529


  48. Mitchell J, Siboo IR, Takamatsu D, Chambers HF, Sullam PM. Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB. Volume 64 of Issue 3. 2007. PMID: 17462028


  49. Bensing BA, Siboo IR, Sullam PM. Glycine residues in the hydrophobic core of the GspB signal sequence route export toward the accessory Sec pathway. Volume 189 of Issue 10. 2007. PMID: 17369296


  50. Takamatsu D, Bensing BA, Prakobphol A, Fisher SJ, Sullam PM. Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins. Volume 74 of Issue 3. 2006. PMID: 16495569


  51. Bensing BA, Takamatsu D, Sullam PM. Determinants of the streptococcal surface glycoprotein GspB that facilitate export by the accessory Sec system. Volume 58 of Issue 5. 2005. PMID: 16313630


  52. Takamatsu D, Bensing BA, Cheng H, Jarvis GA, Siboo IR, López JA, Griffiss JM, Sullam PM. Binding of the Streptococcus gordonii surface glycoproteins GspB and Hsa to specific carbohydrate structures on platelet membrane glycoprotein Ibalpha. Volume 58 of Issue 2. 2005. PMID: 16194227


  53. Paul Sullam, Julie Higashi. Staphylococcus aureus Biofilms. 2005. PMID:


  54. Siboo IR, Chambers HF, Sullam PM. Role of SraP, a Serine-Rich Surface Protein of Staphylococcus aureus, in binding to human platelets. Volume 73 of Issue 4. 2005. PMID: 15784571


  55. Bensing BA, Gibson BW, Sullam PM. The Streptococcus gordonii platelet binding protein GspB undergoes glycosylation independently of export. Volume 186 of Issue 3. 2004. PMID: 14729688


  56. Siboo IR, Bensing BA, Sullam PM. Genomic organization and molecular characterization of SM1, a temperate bacteriophage of Streptococcus mitis. Volume 185 of Issue 23. 2003. PMID: 14617660


  57. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. Volume 171 of Issue 2. 2003. PMID: 12847223


  58. Larry M. Baddour, Paul M. Sullam, Arnold S. Bayer. 47 Pathogenesis of Infective Endocarditis. 2002. PMID:


  59. Siboo IR, Cheung AL, Bayer AS, Sullam PM. Clumping factor A mediates binding of Staphylococcus aureus to human platelets. 2001. PMID: 11292731


  60. Bensing BA, Rubens CE, Sullam PM. Genetic loci of Streptococcus mitis that mediate binding to human platelets. 2001. PMID: 11179301


  61. Victor Nizet, Arnold L. Smith, Paul M. Sullam, Craig E. Rubens. A simple microtiter plate screening assay for bacterial invasion or adherence. 1998. PMID:


  62. Victor Nizet, Arnold L. Smith, Paul M. Sullam, Craig E. Rubens. A simple microtiter plate screening assay for bacterial invasion or adherence. 1998. PMID:


  63. Gordin FM, Cohn DL, Sullam PM, Schoenfelder JR, Wynne BA, Horsburgh CR. Early manifestations of disseminated Mycobacterium avium complex disease: a prospective evaluation. 1997. PMID: 9207358


  64. C. Robert Horsburgh, John R. Schoenfelder, Fred M. Gordin, David L. Cohn, Paul M. Sullam, Beverley A. Wynne. Geographic and Seasonal Variation in Mycobacterium avium Bacteremia Among North American Patients With AIDS. 1997. PMID:


  65. Horsburgh CR, Schoenfelder JR, Gordin FM, Cohn DL, Sullam PM, Wynne BA. Geographic and seasonal variation in Mycobacterium avium bacteremia among North American patients with AIDS. 1997. PMID: 9186148


  66. D. Colbom, H. Lampiris, B. Lee, R. Lewis, P. Sullam, P.K. Narang. Concomitant Cotrimoxazole (CTX) Does Not Affect Rifabutin (RBT) Kinetics in HIV+ Patients. 1996. PMID:


  67. Bresalier RS, Schwartz B, Kim YS, Duh QY, Kleinman HK, Sullam PM. The laminin alpha 1 chain Ile-Lys-Val-Ala-Val (IKVAV)-containing peptide promotes liver colonization by human colon cancer cells. 1995. PMID: 7758002


  68. Cheung AL, Eberhardt KJ, Chung E, Yeaman MR, Sullam PM, Ramos M, Bayer AS. Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. 1994. PMID: 7962526


  69. Yeaman MR, Sullam PM, Dazin PF, Ghannoum MA, Edwards JE, Bayer AS. Fluconazole and platelet microbicidal protein inhibit Candida adherence to platelets in vitro. 1994. PMID: 7979272


  70. Cheung AL, Yeaman MR, Sullam PM, Witt MD, Bayer AS. Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits. 1994. PMID: 8168933


  71. Sullam PM, Frank U, Yeaman MR, Täuber MG, Bayer AS, Chambers HF. Effect of thrombocytopenia on the early course of streptococcal endocarditis. 1993. PMID: 8376837


  72. Nightingale SD, Cameron DW, Gordin FM, Sullam PM, Cohn DL, Chaisson RE, Eron LJ, Sparti PD, Bihari B, Kaufman DL. Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. 1993. PMID: 8179648


  73. Lee BL, Wong D, Benowitz NL, Sullam PM. Altered patterns of drug metabolism in patients with acquired immunodeficiency syndrome. 1993. PMID: 8491064


  74. Sullam PM, Costerton JW, Yamasaki R, Dazin PF, Mills J. Inhibition of platelet binding and aggregation by streptococcal exopolysaccharide. 1993. PMID: 8486945


  75. Yeaman MR, Sullam PM, Dazin PF, Norman DC, Bayer AS. Characterization of Staphylococcus aureus-platelet binding by quantitative flow cytometric analysis. 1992. PMID: 1318911


  76. Sullam PM, Payan DG, Dazin PF, Valone FH. Binding of viridans group streptococci to human platelets: a quantitative analysis. 1990. PMID: 2228249


  77. Sullam PM, Jarvis GA, Valone FH. Role of immunoglobulin G in platelet aggregation by viridans group streptococci. 1988. PMID: 2971621


  78. Sullam PM, Valone FH, Mills J. Mechanisms of platelet aggregation by viridans group streptococci. 1987. PMID: 3112008


  79. Sullam PM, Slutkin G, Gottlieb AB, Mills J. Paromomycin therapy of endemic amebiasis in homosexual men. 1986. PMID: 3764625


  80. Sullam PM, Drake TA, Sande MA. Pathogenesis of endocarditis. 1985. PMID: 4014276


  81. Sullam PM, Täuber MG, Hackbarth CJ, Sande MA. Antimicrobial activity of gentamicin in experimental enterococcal endocarditis. 1985. PMID: 3920960


  82. Sullam PM, Täuber MG, Hackbarth CJ, Sande MA. Therapeutic efficacy of teicoplanin in experimental enterococcal endocarditis. 1985. PMID: 3157344


  83. Sullam PM, Falk RH. Cardiac tamponade with refeeding in malnutrition. 1983. PMID: 6869231


  84. Podell TE, Ault M, Sullam P, Klinenberg JR. Synovial fluid eosinophilia. 1980. PMID: 7417355