Laurence Huang, MD

Professor

I am a pulmonary and critical care medicine specialist with a research focus on pulmonary diseases affecting persons with HIV with a global perspective. I am a clinical-translational researcher with clinical cohorts in San Francisco, CA and in Kampala, Uganda.

Currently, I am PI/Co-PI on these main studies:

I AM OLD and I AM OLD-DA (renewal): The Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study and The Inflammation, Aging, Microbes, Obstructive Lung Disease, and Diffusion Abnormalities (I AM OLD-DA) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine potential mechanisms for development of obstructive lung disease and progression of airflow obstruction and diffusion abnormalities in a multi-national cohort of HIV-infected subjects with opportunistic pneumonia.

I AM GOLD: The Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine airway microbial communities (the lung microbiome) and inflammatory gene expression markers at the time of acute infection and during chronic stable disease that are associated with HIV-associated COPD and lung function decline in HIV and to perform integrative analyses of the airway microbiome, microbial and human transcriptome, metabolome and lung radiographic changes in HIV-associated COPD.

Recent, former studies:
IHOP: The International HIV-associated Opportunistic Pneumonias (IHOP) Study is a multi-national cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to improve our understanding of the epidemiology, etiology, and outcome of pneumonias in persons with HIV infection. IHOP was part of the Lung HIV Study, a collaborative multi-R01 consortium established by the National Heart, Lung, and Blood Institute (NHLBI) to examine a diverse range of infectious and non-infectious pulmonary diseases in HIV-infected persons.

Lung MicroCHIP: The Lung Microbiome in Cohorts of HIV-Infected Persons (Lung MicroChip) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine the composition and function of the lung microbiome in persons with HIV. Lung MicroChip was part of the Lung HIV Microbiome Project, a collaborative multi-U01 consortium established by the NHLBI to study the lung microbiome in HIV infection.

I am also involved in training the next generation of clinical and translational researchers at both fellowship and junior faculty levels, including through the following NIH-funded training programs:

Multidisciplinary Training Program in Lung Disease (NIH T32 HL007185): This is a continuation of the UCSF Multidisciplinary Training Program in Lung Disease, which provides training in basic and clinical sciences important to the respiratory system. The program draws on the basic and clinical research skills of the broad group of faculty at UCSF addressing questions directly relevant to lung biology and disease. The grant is to accommodate a total of 13 postdoctoral trainees, including both MDs and PhDs. The main program is an actual research experience under the close supervision of a Preceptor and a review committee selected on the basis of the experimental approaches of the trainee. These approaches include disciplines applicable at the molecular, cellular, tissue, organ, whole animal, clinical, or population levels.

CHIC (NIH K12 HL143961): The UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC) is a K12 training grant whose goals are: (1) To recruit MD, MD/PhD and PhD scholars dedicated to independent research careers conducting clinical and translational research in HIV-related heart, lung, and blood research; (2) To design, implement, and monitor individualized and tailored research training and career development of these scholars using an interdisciplinary, team-science, and team-mentoring approach that combines didactic training in research methods with supervised research under the mentorship of an experienced faculty mentor and mentoring team; (3) To produce the ‘next generation’ of researchers in HIV-associated heart, lung and blood diseases.
Education
06/1995 - Pulmonary & Critical Care Medicine, University of California San Francisco
06/1992 - Internal Medicine, Columbia Presbyterian Medical Center
MD, 05/1989 - Medicine, Columbia College of Physicians & Surgeons
BA, 05/1985 - Biology, Johns Hopkins University
Honors and Awards
  • Division of Pulmonary and Critical Care Medicine V. Courtney Broaddus Leadership & Service Award, University of California San Francisco, 2023
  • World Lung Health Award, American Thoracic Society, 2022
  • Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine Outstanding Mentor Award, University of California San Francisco, 2019
  • Selected as American Thoracic Society Fellow, ATSF (inaugural class), American Thoracic Society, 2018
  • Microbiology, Tuberculosis, and Pulmonary Infections Assembly Senior-Level Peer Recognition Award, American Thoracic Society, 2017
  • UCSF Pathways to Discovery 2016-2017 Short-Term Mentor Award, University of California San Francisco, 2016-2017
  • Henry F. (Chip) Chambers Medicine Service Subspecialist Consultant of the Year Award, San Francisco General Hospital, 2014
  • Positive Health Program Award for Teaching Excellence-Meg Newman Teaching Award, University of California San Francisco, 2009
  • Haile T. Debas Academy of Medical Educators Excellence in Direct Teaching Award, University of California San Francisco, 2005
  • George S. Sarlo Award for Excellence in Teaching and Mentoring, University of California San Francisco AIDS Research Institute, 2005
  • James H. Nakano Citation (for Outstanding Scientific Paper published in 2000), Centers for Disease Control and Prevention, 2001
  • Community Based Teaching Excellence and Preceptorship Award, American College of Physicians-American Society of Internal Medicine, 2000
  • SFGH Positive Health Program Outstanding Teacher and Lecturer Award, San Francisco General Hospital, 2000
  • Elected as Fellow College of Chest Physicians (FCCP), American College of Chest Physicians, 1998
  • 4th Annual Steve Chase Humanitarian Award, Desert AIDS Project-presented to members of San Francisco General Hospital’s Inpatient AIDS Unit, 1998
  • Walter Travel Fund Award, American Lung Association, 1995
  • Omicron Delta Kappa-National Leadership Honor Society, Johns Hopkins University, 1984
Websites
Publications

  1. Byanova KL, Abelman R, North CM, Christenson SA, Huang L. COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies. 2023. PMID: 38050482


  3. Konstantinidis I, Crothers K, Kunisaki KM, Drummond MB, Benfield T, Zar HJ, Huang L, Morris A. HIV-associated lung disease. 2023. PMID: 37500684


  4. Byanova KL, Fitzpatrick J, Jan AK, McGing M, Hartman-Filson M, Farr CK, Zhang M, Gardner K, Branchini J, Kerruish R, Bhide S, Bates A, Hsieh J, Abelman R, Hunt PW, Wang RJ, Crothers KA, Huang L. Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection. 2023. PMID: 37463173


  5. Abelman RA, Fitzpatrick J, Zawedde J, Sanyu I, Byanyima P, Kaswabuli S, Musisi E, Hsieh J, Gardner K, Zhang M, Byanova KL, Sessolo A, Hunt PW, Lalitha R, Davis JL, Crothers K, Worodria W, Huang L. Sex modifies the risk of HIV-associated obstructive lung disease in ugandans post-pneumonia. 2023. PMID: 37352494


  6. Dunlap DG, Yang L, Qin S, Li K, Fitch A, Huang L, McVerry BJ, Hand TW, Methé BA, Morris A. Magnetic-activated cell sorting identifies a unique lung microbiome community. 2023. PMID: 37226179


  7. Sessolo A, Musisi E, Kaswabuli S, Zawedde J, Byanyima P, Sabiiti W, Walimbwa S, Ola J, Sanyu I, Lalitha R, Kamya M, Davis L, Worodria W, Huang L. Diagnostic accuracy of Xpert MTB/RIF Ultra and culture assays to detect Mycobacterium Tuberculosis using OMNIgene-sputum processed stool among adult TB presumptive patients in Uganda. 2023. PMID: 37083706


  8. Wang RJ, Nouraie M, Kunisaki KM, Huang L, Tien PC, Anastos K, Bhandari N, Bhatt SP, Bolivar H, Cribbs SK, Foronjy R, Gange SJ, Lazarous D, Morris A, Drummond MB. Lung Function in Women with and without HIV. 2022. PMID: 35604821


  9. Drummond MB, Edmonds A, Ramirez C, Stosor V, Barjaktarevic IZ, Morris A, McCormack MC, Bhatt SP, Alcaide ML, Cribbs SK, D'Souza G, Bhandari N, Kunisaki KM, Huang L, Kassaye SG, Foronjy R, Sharma A, Westreich DJ, Adimora AA. Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study. 2022. PMID: 36083508


  10. Konstantinidis I, Qin S, Fitzpatrick M, Kessinger C, Gentry H, McMahon D, Weinman RD, Tien P, Huang L, McCormack M, Barjaktarevic I, Reddy D, Foronjy R, Lazarous D, Cohen MH, McKay H, Adimora AA, Moran C, Fischl MA, Dionne-Odom J, Stosor V, Drummond MB, Cribbs SK, Kunisaki K, Rinaldo C, Morris A, Nouraie SM. Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort. 2022. PMID: 35939796


  11. Byanyima P, Kaswabuli S, Musisi E, Nabakiibi C, Zawedde J, Sanyu I, Sessolo A, Andama A, Worodria W, Huang L, Davis JL. Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda. 2022. PMID: 36154664


  12. Kaswabuli S, Musisi E, Byanyima P, Sessolo A, Sanyu I, Zawedde J, Worodria W, Huang L, Okeng A, Bwanga F. Accuracy of GenoQuick MTB test in detection of Mycobacterium tuberculosis in sputum from TB presumptive patients in Uganda. 2022. PMID: 35993094


  13. Cyktor J, Qin S, Staines B, Nouraie M, Fitzpatrick M, Kessinger C, DeSensi R, Huang L, Rinaldo CR, Kingsley L, Tien PC, Mellors JW, Morris A. Associations of HIV persistence, cigarette smoking, inflammation, and pulmonary dysfunction in people with HIV on antiretroviral therapy. 2022. PMID: 35801755


  14. Sellers SA, Edmonds A, Ramirez C, Cribbs SK, Ofotokun I, Huang L, Morris A, Mccormack MC, Kunisaki KM, D'souza G, Rivera MP, Drummond MB, Adimora AA. Optimal Lung Cancer Screening Criteria Among Persons Living With HIV. 2022. PMID: 35125470


  15. Spottiswoode N, Bloomstein JD, Caldera S, Sessolo A, McCauley K, Byanyima P, Zawedde J, Kalantar K, Kaswabuli S, Rutishauser RL, Lieng MK, Davis JL, Moore J, Jan A, Iwai S, Shenoy M, Sanyu I, DeRisi JL, Lynch SV, Worodria W, Huang L, Langelier CR. Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study. 2022. PMID: 35544096


  16. Li W, Syed F, Yu R, Yang J, Xia Y, Relich RF, Russell PM, Zhang S, Khalili M, Huang L, Kacena MA, Zheng X, Yu Q. Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection. 2022. PMID: 35281051


  17. Musisi E, Sessolo A, Kaswabuli S, Zawedde J, Byanyima P, Kasinga S, Sanyu I, Uwimaana E, Walimbwa S, Olore J, Ssengooba W, Sekaggya C, Joloba ML, Worodria W, Huang L, Gillespie SH, Sloan DJ, Sabiiti W. High Mycobacterium tuberculosis Bacillary Loads Detected by Tuberculosis Molecular Bacterial Load Assay in Patient Stool: a Potential Alternative for Nonsputum Diagnosis and Treatment Response Monitoring of Tuberculosis. 2022. PMID: 35019686


  18. Akgün KM, Krishnan S, Butt AA, Gibert CL, Graber CJ, Huang L, Pisani MA, Rodriguez-Barradas MC, Hoo GWS, Justice AC, Crothers K, Tate JP. CD4+ cell count and outcomes among HIV-infected compared with uninfected medical ICU survivors in a national cohort. 2021. PMID: 34261095


  19. Zifodya JS, Triplette M, Shahrir S, Attia EF, Akgun KM, Soo Hoo GW, Rodriguez-Barradas MC, Wongtrakool C, Huang L, Crothers K. A cross-sectional analysis of diagnosis and management of chronic obstructive pulmonary disease in people living with HIV: Opportunities for improvement. 2021. PMID: 34664836


  20. Musisi E, Dide-Agossou C, Al Mubarak R, Rossmassler K, Ssesolo AW, Kaswabuli S, Byanyima P, Sanyu I, Zawedde J, Worodria W, Voskuil MI, Savic RM, Nahid P, Davis JL, Huang L, Moore CM, Walter ND. Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden. 2021. PMID: 34494858


  21. Singhvi DG, Nouraie M, Kessinger C, McMahon DK, Weinman R, Crothers K, Huang L, Bon J, Morris A, Merlin J. Brief Report: Association Between Pain, Pulmonary Function, and Respiratory Symptoms in People With HIV. 2021. PMID: 33871410


  22. Jan AK, Moore JV, Wang RJ, Mcging M, Farr CK, Moisi D, Hartman-Filson M, Kerruish R, Jeon D, Lewis E, Crothers K, Lederman MM, Hunt PW, Huang L. Markers of inflammation and immune activation are associated with lung function in a multicenter cohort of persons with HIV. 2021. PMID: 33635847


  23. Walter ND, Born SEM, Robertson GT, Reichlen M, Dide-Agossou C, Ektnitphong VA, Rossmassler K, Ramey ME, Bauman AA, Ozols V, Bearrows SC, Schoolnik G, Dolganov G, Garcia B, Musisi E, Worodria W, Huang L, Davis JL, Nguyen NV, Nguyen HV, Nguyen ATV, Phan H, Wilusz C, Podell BK, Sanoussi ND, de Jong BC, Merle CS, Affolabi D, McIlleron H, Garcia-Cremades M, Maidji E, Eshun-Wilson F, Aguilar-Rodriguez B, Karthikeyan D, Mdluli K, Bansbach C, Lenaerts AJ, Savic RM, Nahid P, Vásquez JJ, Voskuil MI. Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens. 2021. PMID: 34006838


  24. Kuniholm MH, Bramah-Lawani M, Fitzpatrick M, Nouraie M, Qin S, Huang L, Vallejo AN, Landay AL, Morris A. Association of monocyte migration marker CD11b with pulmonary function in people living with HIV. 2020. PMID: 33148999


  25. Meyer AJ, Ochom E, Turimumahoro P, Byanyima P, Sanyu I, Lalitha R, Kaswabuli S, Andama A, Walter ND, Katamba A, Cattamanchi A, Worodria W, Huang L, Yoon C, Davis JL. C-Reactive Protein for Active Tuberculosis Among Inpatients without HIV in Uganda: A Diagnostic Accuracy Study. 2020. PMID: 33087439


  26. Byanova K, Kunisaki KM, Vasquez J, Huang L. Chronic obstructive pulmonary disease in HIV. 2020. PMID: 33167728


  27. Zifodya JS, Duncan MS, So-Armah KA, Attia EF, Akgün KM, Rodriguez-Barradas MC, Marconi VC, Budoff MJ, Bedimo RJ, Alcorn CW, Soo Hoo GW, Butt AA, Kim JW, Sico JJ, Tindle HA, Huang L, Tate JP, Justice AC, Freiberg MS, Crothers K. Community-Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV. 2020. PMID: 33222591


  28. Wenger DS, Triplette M, Shahrir S, Akgun KM, Wongtrakool C, Brown ST, Kim JW, Soo Hoo GW, Rodriguez-Barradas MC, Huang L, Feemster LC, Zifodya J, Crothers K. Associations of marijuana with markers of chronic lung disease in people living with HIV. 2020. PMID: 33022830


  29. Bhadriraju S, Fadrosh DW, Shenoy MK, Lin DL, Lynch KV, McCauley K, Ferrand RA, Majonga ED, McHugh G, Huang L, Lynch SV, Metcalfe JZ. Distinct lung microbiota associate with HIV-associated chronic lung disease in children. 2020. PMID: 32999331


  30. Wang RJ, Katha G, Phiri M, Delbridge P, Gordon SB, Calfee CS, Huang L, Rylance J. Sonographic B-Lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis. 2020. PMID: 32286847


  31. Rodriguez-Barradas MC, McGinnis KA, Akgün K, Tate JP, Brown ST, Butt AA, Fine M, Goetz MB, Graber CJ, Huang L, Rimland D, Justice A, Crothers K. Validation for using electronic health records to identify community acquired pneumonia hospitalization among people with and without HIV. 2020. PMID: 32724760


  32. Almodovar S, Wade BE, Porter KM, Smith JM, Lopez-Astacio RA, Bijli K, Kang BY, Cribbs SK, Guidot DM, Molehin D, McNair BK, Pumarejo-Gomez L, Perez Hernandez J, Salazar EA, Martinez EG, Huang L, Kessing CF, Suarez-Martinez EB, Pruitt K, Hsue PY, Tyor WR, Flores SC, Sutliff RL. HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension. 2020. PMID: 32678115


  33. Qin S, Vodovotz L, Zamora R, Fitzpatrick M, Kessinger C, Kingsley L, McMahon D, DeSensi R, Leader JK, Crothers K, Huang L, Morris A, Nouraie M. Association Between Inflammatory Pathways and Phenotypes of Pulmonary Dysfunction Using Cluster Analysis in Persons Living With HIV and HIV-Uninfected Individuals. 2020. PMID: 31929407


  34. Jeon D, Chang EG, McGing M, Hartman-Filson M, Sommers M, Lewis E, Balmes JR, Moisi D, Lederman MM, Madsen KA, Woodruff PG, Hunt PW, Huang L. Pneumoproteins are associated with pulmonary function in HIV-infected persons. 2019. PMID: 31574118


  35. North CM, Attia EF, Rudd KE, Siddharthan T, Papali A, Çoruh B, Carter EJ, Christiani DC, Richards JB, Huang L, Engelberg R, Checkley W, West TE. Global Health-related Training Opportunities. A National Survey of Pulmonary and Critical Care Medicine Fellowship Programs. 2019. PMID: 31199665


  36. Wang S, Chang E, Byanyima P, Huang P, Sanyu I, Musisi E, Sessolo A, Davis JL, Worodria W, Huang L, Lin J. Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB. 2019. PMID: 31388112


  37. Wang RJ, Moore J, Moisi D, Chang EG, Byanyima P, Kaswabuli S, Musisi E, Sanyu I, Sessolo A, Lalitha R, Worodria W, Davis JL, Crothers K, Lin J, Lederman MM, Hunt PW, Huang L. HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. 2019. PMID: 31091258


  38. Robertson TE, Nouraie M, Qin S, Crothers KA, Kessinger CJ, McMahon D, Chandra D, Kingsley LA, Greenblatt RM, Huang L, Fitzpatrick ME, Morris A. HIV infection is an independent risk factor for decreased 6-minute walk test distance. 2019. PMID: 31017909


  39. Shenoy MK, Fadrosh DW, Lin DL, Worodria W, Byanyima P, Musisi E, Kaswabuli S, Zawedde J, Sanyu I, Chang E, Fong S, McCauley K, Davis JL, Huang L, Lynch SV. Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. 2019. PMID: 30857553


  40. Rentsch CT, Tate JP, Steel T, Butt AA, Gibert CL, Huang L, Pisani M, Soo Hoo GW, Crystal S, Rodriguez-Barradas MC, Brown ST, Freiberg MS, Graber CJ, Kim JW, Rimland D, Justice AC, Fiellin DA, Crothers KA, Akgün KM. Medical Intensive Care Unit Admission Among Patients With and Without HIV, Hepatitis C Virus, and Alcohol-Related Diagnoses in the United States: A National, Retrospective Cohort Study, 1997-2014. 2019. PMID: 30422912


  41. Worodria W, Chang E, Andama A, Sanyu I, Byanyima P, Musisi E, Kaswabuli S, Zawedde J, Ayakaka I, Sessolo A, Lalitha R, Davis JL, Huang L. Predictors of Mortality Among Hospitalized Patients With Lower Respiratory Tract Infections in a High HIV Burden Setting. 2018. PMID: 30222660


  42. Li Y, Nouraie SM, Kessinger C, Weinman R, Huang L, Greenblatt RM, Kleerup E, Kingsley L, McMahon D, Fitzpatrick M, Morris A. Factors Associated With Progression of Lung Function Abnormalities in HIV-Infected Individuals. 2018. PMID: 30142142


  44. Farr K, Ravindran R, Strnad L, Chang E, Chaisson LH, Yoon C, Worodria W, Andama A, Ayakaka I, Bbosa Nalwanga P, Byanyima P, Kalema N, Kaswabuli S, Katagira W, Aman KD, Musisi E, Tumwine NW, Sanyu I, Ssebunya R, Davis JL, Huang L, Khan IH, Cattamanchi A. Diagnostic performance of blood inflammatory markers for tuberculosis screening in people living with HIV. 2018. PMID: 30352099


  45. Qin S, Clausen E, Nouraie SM, Kingsley L, McMahon D, Kleerup E, Huang L, Ghedin E, Greenblatt RM, Morris A. Tropheryma whipplei colonization in HIV-infected individuals is not associated with lung function or inflammation. 2018. PMID: 30286195


  46. Musisi E, Matovu DK, Bukenya A, Kaswabuli S, Zawedde J, Andama A, Byanyima P, Sanyu I, Sessolo A, Seremba E, Davis JL, Worodria W, Huang L, Walter ND, Mayanja-Kizza H. Effect of anti-retroviral therapy on oxidative stress in hospitalized HIV-infected adults with and without TB. 2018. PMID: 30602982


  47. Walter ND, Moore CM, Kayigire XA, Dide-Agossou C, Worodria W, Huang L, Everett CK, Schoolnik GS, Nahid P, Davis JL. Does discovery of differentially culturable M tuberculosis really demand a new treatment paradigm? Longitudinal analysis of DNA clearance from sputum. 2018. PMID: 29970012


  48. Tipton L, Cuenco KT, Huang L, Greenblatt RM, Kleerup E, Sciurba F, Duncan SR, Donahoe MP, Morris A, Ghedin E. Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. 2018. PMID: 29983746


  49. Gingo MR, Nouraie M, Kessinger CJ, Greenblatt RM, Huang L, Kleerup EC, Kingsley L, McMahon DK, Morris A. Decreased Lung Function and All-Cause Mortality in HIV-infected Individuals. 2018. PMID: 29313714


  50. Tipton L, Müller CL, Kurtz ZD, Huang L, Kleerup E, Morris A, Bonneau R, Ghedin E. Fungi stabilize connectivity in the lung and skin microbial ecosystems. 2018. PMID: 29335027


  51. Block BL, Mehta T, Ortiz GM, Ferris SP, Vu TH, Huang L, Cattamanchi A. Unusual Radiographic Presentation of Pneumocystis Pneumonia in a Patient with AIDS. 2017. PMID: 29362681


  52. Yoon C, Semitala FC, Atuhumuza E, Katende J, Mwebe S, Asege L, Armstrong DT, Andama AO, Dowdy DW, Davis JL, Huang L, Kamya M, Cattamanchi A. Point-of-care C-reactive protein-based tuberculosis screening for people living with HIV: a diagnostic accuracy study. 2017. PMID: 28847636


  53. Shete PB, Ravindran R, Chang E, Worodria W, Chaisson LH, Andama A, Davis JL, Luciw PA, Huang L, Khan IH, Cattamanchi A. Evaluation of antibody responses to panels of M. tuberculosis antigens as a screening tool for active tuberculosis in Uganda. 2017. PMID: 28767658


  54. Blount RJ, Daly KR, Fong S, Chang E, Grieco K, Greene M, Stone S, Balmes J, Miller RF, Walzer PD, Huang L. Effects of clinical and environmental factors on bronchoalveolar antibody responses to Pneumocystis jirovecii: A prospective cohort study of HIV+ patients. 2017. PMID: 28692651


  55. Meyer AJ, Atuheire C, Worodria W, Kizito S, Katamba A, Sanyu I, Andama A, Ayakaka I, Cattamanchi A, Bwanga F, Huang L, Davis JL. Sputum quality and diagnostic performance of GeneXpert MTB/RIF among smear-negative adults with presumed tuberculosis in Uganda. 2017. PMID: 28686705


  57. Kelly-Cirino CD, Musisi E, Byanyima P, Kaswabuli S, Andama A, Sessolo A, Sanyu I, Zawedde J, Curry PS, Huang L. Investigation of OMNIgene·SPUTUM performance in delayed tuberculosis testing by smear, culture, and Xpert MTB/RIF assays in Uganda. 2017. PMID: 28413105


  58. Morris A, Fitzpatrick M, Bertolet M, Qin S, Kingsley L, Leo N, Kessinger C, Michael H, Mcmahon D, Weinman R, Stone S, Leader JK, Kleerup E, Huang L, Wisniewski SR. Use of rosuvastatin in HIV-associated chronic obstructive pulmonary disease. 2017. PMID: 27941393


  59. Triplette M, Attia EF, Akgün KM, Soo Hoo GW, Freiberg MS, Butt AA, Wongtrakool C, Goetz MB, Brown ST, Graber CJ, Huang L, Crothers K. A Low Peripheral Blood CD4/CD8 Ratio Is Associated with Pulmonary Emphysema in HIV. 2017. PMID: 28122034


  61. Shenoy MK, Iwai S, Lin DL, Worodria W, Ayakaka I, Byanyima P, Kaswabuli S, Fong S, Stone S, Chang E, Davis JL, Faruqi AA, Segal MR, Huang L, Lynch SV. Immune Response and Mortality Risk Relate to Distinct Lung Microbiomes in Patients with HIV and Pneumonia. 2017. PMID: 27447987


  62. Kalema N, Lindan C, Glidden D, Yoo SD, Katamba A, Alfred A, Katagira W, Byanyima P, Musisi E, Kaswabuli S, Ingvar S, Zawedde J, Yoon C, Ayakaka I, Davis JL, Huang L, Worodria W, Cattamanchi A. Predictors and short-term outcomes of recurrent pulmonary tuberculosis, Uganda: a cohort study. 2017. PMID: 29368752


  63. Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L. HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis. 2016. PMID: 27655116


  64. Walter ND, de Jong BC, Garcia BJ, Dolganov GM, Worodria W, Byanyima P, Musisi E, Huang L, Chan ED, Van TT, Antonio M, Ayorinde A, Kato-Maeda M, Nahid P, Leung AM, Yen A, Fingerlin TE, Kechris K, Strong M, Voskuil MI, Davis JL, Schoolnik GK. Adaptation of Mycobacterium tuberculosis to Impaired Host Immunity in HIV-Infected Patients. 2016. PMID: 27534685


  65. Katagira W, Walter ND, Den Boon S, Kalema N, Ayakaka I, Vittinghoff E, Worodria W, Cattamanchi A, Huang L, Davis JL. Empiric TB Treatment of Severely Ill Patients With HIV and Presumed Pulmonary TB Improves Survival. 2016. PMID: 26918546


  66. Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, Li Y, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. 2016. PMID: 27572644


  67. Leader JK, Crothers K, Huang L, King MA, Morris A, Thompson BW, Flores SC, Drummond MB, Rom WN, Diaz PT. Risk Factors Associated With Quantitative Evidence of Lung Emphysema and Fibrosis in an HIV-Infected Cohort. 2016. PMID: 26914911


  68. Esteves F, de Sousa B, Calderón EJ, Huang L, Badura R, Maltez F, Bassat Q, de Armas Y, Antunes F, Matos O. Multicentre study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia. 2016. PMID: 27021425


  69. Maximous S, Huang L, Morris A. Evaluation and Diagnosis of HIV-Associated Lung Disease. 2016. PMID: 26974298


  71. Huang L, Morris A, Crothers K. Pulmonary Complications of HIV Infection. 2016. PMID: 26974293


  72. Cribbs SK, Uppal K, Li S, Jones DP, Huang L, Tipton L, Fitch A, Greenblatt RM, Kingsley L, Guidot DM, Ghedin E, Morris A. Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection. 2016. PMID: 26792212


  73. Beck JM, Schloss PD, Venkataraman A, Twigg H, Jablonski KA, Bushman FD, Campbell TB, Charlson ES, Collman RG, Crothers K, Curtis JL, Drews KL, Flores SC, Fontenot AP, Foulkes MA, Frank I, Ghedin E, Huang L, Lynch SV, Morris A, Palmer BE, Schmidt TM, Sodergren E, Weinstock GM, Young VB. Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals. 2015. PMID: 26247840


  74. Attia EF, McGinnis KA, Feemster LC, Akgün KM, Butt AA, Graber CJ, Fine MJ, Goetz MB, Rodriguez-Barradas MC, Pisani MA, Tindle HA, Brown ST, Soo Hoo GW, Rimland D, Gibert CL, Huang L, Freiberg MS, Hough CL, Crothers K. Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans. 2015. PMID: 26181820


  75. Drummond MB, Huang L, Diaz PT, Kirk GD, Kleerup EC, Morris A, Rom W, Weiden MD, Zhao E, Thompson B, Crothers K. Factors associated with abnormal spirometry among HIV-infected individuals. 2015. PMID: 26372280


  76. Juliano JJ, Barnett E, Parobek CM, Taylor SM, Meshnick SR, Stone S, Chang E, Fong S, Huang L. Use of Oropharyngeal Washes to Diagnose and Genotype Pneumocystis jirovecii. 2015. PMID: 26180832


  77. Koss CA, Jarlsberg LG, den Boon S, Cattamanchi A, Davis JL, Worodria W, Ayakaka I, Sanyu I, Huang L. A Clinical Predictor Score for 30-Day Mortality among HIV-Infected Adults Hospitalized with Pneumonia in Uganda. 2015. PMID: 25962069


  78. Semitala FC, Chaisson LH, den Boon S, Walter N, Cattamanchi A, Awor M, Katende J, Huang L, Joloba M, Albert H, Kamya MR, Davis JL. Impact of mycobacterial culture among HIV-infected adults with presumed TB in Uganda: a prospective cohort study. 2015. PMID: 26400379


  79. Cui L, Lucht L, Tipton L, Rogers MB, Fitch A, Kessinger C, Camp D, Kingsley L, Leo N, Greenblatt RM, Fong S, Stone S, Dermand JC, Kleerup EC, Huang L, Morris A, Ghedin E. Topographic diversity of the respiratory tract mycobiome and alteration in HIV and lung disease. 2015. PMID: 25603113


  80. Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL. Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis. 2015. PMID: 25762787


  81. Simonetti JA, Gingo MR, Kingsley L, Kessinger C, Lucht L, Balasubramani G, Leader JK, Huang L, Greenblatt RM, Dermand J, Kleerup EC, Morris A. Pulmonary Function in HIV-Infected Recreational Drug Users in the Era of Anti-Retroviral Therapy. 2014. PMID: 25664201


  82. Cui L, Morris A, Huang L, Beck JM, Twigg HL, von Mutius E, Ghedin E. The microbiome and the lung. 2014. PMID: 25148429


  83. Gingo MR, Balasubramani GK, Rice TB, Kingsley L, Kleerup EC, Detels R, Seaberg EC, Greenblatt RM, Holman S, Huang L, Sutton SH, Bertolet M, Morris A. Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts. 2014. PMID: 24884738


  84. Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV. The lung microbiome of Ugandan HIV-infected pneumonia patients is compositionally and functionally distinct from that of San Franciscan patients. 2014. PMID: 24752365


  85. Campo M, Oursler KK, Huang L, Goetz MB, Rimland D, Hoo GS, Brown ST, Rodriguez-Barradas MC, Au D, Akgün KM, Shahrir S, Crothers K. Association of chronic cough and pulmonary function with 6-minute walk test performance in HIV infection. 2014. PMID: 24346638


  86. Yoon C, Davis JL, Huang L, Muzoora C, Byakwaga H, Scibetta C, Bangsberg DR, Nahid P, Semitala FC, Hunt PW, Martin JN, Cattamanchi A. Point-of-care C-reactive protein testing to facilitate implementation of isoniazid preventive therapy for people living with HIV. Volume 65 of Issue 5. 2014. PMID: 24346636


  87. Parobek CM, Jiang LY, Patel JC, Alvarez-Martínez MJ, Miro JM, Worodria W, Andama A, Fong S, Huang L, Meshnick SR, Taylor SM, Juliano JJ. Multilocus microsatellite genotyping array for investigation of genetic epidemiology of Pneumocystis jirovecii. 2014. PMID: 24523468


  88. Tokman S, Barnett CF, Jarlsberg LG, Taub PR, den Boon S, Davis JL, Cattamanchi A, Worodria W, Maisel A, Huang L. Procalcitonin predicts mortality in HIV-infected Ugandan adults with lower respiratory tract infections. 2014. PMID: 24460728


  89. Blount RJ, Djawe K, Daly KR, Jarlsberg LG, Fong S, Balmes J, Miller RF, Walzer PD, Huang L. Ambient air pollution associated with suppressed serologic responses to Pneumocystis jirovecii in a prospective cohort of HIV-infected patients with Pneumocystis pneumonia. 2013. PMID: 24236202


  90. Fitzpatrick ME, Gingo MR, Kessinger C, Lucht L, Kleerup E, Greenblatt RM, Claman D, Ponath C, Fong S, Huang L, Morris A. HIV infection is associated with diffusing capacity impairment in women. 2013. PMID: 23979000


  91. Crothers K, McGinnis K, Kleerup E, Wongtrakool C, Hoo GS, Kim J, Sharafkhaneh A, Huang L, Luo Z, Thompson B, Diaz P, Kirk GD, Rom W, Detels R, Kingsley L, Morris A. HIV infection is associated with reduced pulmonary diffusing capacity. 2013. PMID: 23979001


  92. Fong S, Daly KR, Tipirneni R, Jarlsberg LG, Djawe K, Koch JV, Swartzman A, Roth B, Walzer PD, Huang L. Antibody responses against Pneumocystis jirovecii in health care workers over time. 2013. PMID: 24048016


  93. Twigg HL, Morris A, Ghedin E, Curtis JL, Huffnagle GB, Crothers K, Campbell TB, Flores SC, Fontenot AP, Beck JM, Huang L, Lynch S, Knox KS, Weinstock G. Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise. 2013. PMID: 24429191


  94. Huang YJ, Charlson ES, Collman RG, Colombini-Hatch S, Martinez FD, Senior RM. The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report. 2013. PMID: 23614695


  95. Akgün KM, Tate JP, Pisani M, Fried T, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Medical ICU admission diagnoses and outcomes in human immunodeficiency virus-infected and virus-uninfected veterans in the combination antiretroviral era. 2013. PMID: 23507717


  96. Andama AO, den Boon S, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L. Prevalence and outcomes of cryptococcal antigenemia in HIV-seropositive patients hospitalized for suspected tuberculosis in Uganda. Volume 63 of Issue 2. 2013. PMID: 23542636


  98. Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. 2013. PMID: 23491408


  99. Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP. Widespread colonization of the lung by Tropheryma whipplei in HIV infection. 2013. PMID: 23392441


  100. Everett CK, Subramanian A, Jarisberg LG, Fei M, Huang L. Characteristics of Drug-Susceptible and Drug-Resistant Staphylococcus aureus Pneumonia in Patients with HIV. 2013. PMID: 25346868


  101. Tokman S, Huang L. Evaluation of respiratory disease. 2013. PMID: 23702170


  102. Miller RF, Huang L, Walzer PD. Pneumocystis pneumonia associated with human immunodeficiency virus. 2013. PMID: 23702173


  103. Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, Worodria W, Huang L, Fletcher DA, Cattamanchi A. Mobile digital fluorescence microscopy for diagnosis of tuberculosis. 2013. PMID: 23554191


  104. Gingo MR, Balasubramani GK, Kingsley L, Rinaldo CR, Alden CB, Detels R, Greenblatt RM, Hessol NA, Holman S, Huang L, Kleerup EC, Phair J, Sutton SH, Seaberg EC, Margolick JB, Wisniewski SR, Morris A. The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. 2013. PMID: 23554932


  105. Yoon C, Subramanian A, Chi A, Crothers K, Meshnick SR, Taylor SM, Beard CB, Jarlsberg LG, Lawrence GG, Avery M, Swartzman A, Fong S, Roth B, Huang L. Dihydropteroate synthase mutations in Pneumocystis pneumonia: impact of applying different definitions of prophylaxis, mortality endpoints and mutant in a single cohort. 2013. PMID: 23470037


  106. Baxi S, Platts-Mills J, Dhruva S, Huang L, Hanks D, Dhaliwal G. A double-edged sword. 2013. PMID: 23293015


  107. Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk factors for hospitalization and medical intensive care unit (MICU) admission among HIV-infected Veterans. 2013. PMID: 23111572


  108. Blount RJ, Jarlsberg LG, Daly KR, Worodria W, Davis JL, Cattamanchi A, Djawe K, Andama A, Koch J, Walzer PD, Huang L. Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptoms. 2012. PMID: 23284710


  109. Taylor SM, Meshnick SR, Worodria W, Andama A, Cattamanchi A, Davis JL, Yoo SD, Byanyima P, Kaswabuli S, Goodman CD, Huang L. Low prevalence of Pneumocystis pneumonia (PCP) but high prevalence of pneumocystis dihydropteroate synthase (dhps) gene mutations in HIV-infected persons in Uganda. 2012. PMID: 23166805


  110. Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L. Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in Uganda. 2012. PMID: 23139799


  111. Djawe K, Levin L, Swartzman A, Fong S, Roth B, Subramanian A, Grieco K, Jarlsberg L, Miller RF, Huang L, Walzer PD. Environmental risk factors for Pneumocystis pneumonia hospitalizations in HIV patients. 2012. PMID: 23042978


  112. Nakiyingi L, Kateete DP, Ocama P, Worodria W, Sempa JB, Asiimwe BB, Katabazi FA, Katamba A, Huang L, Joloba ML, Mayanja-Kizza H. Evaluation of in-house PCR for diagnosis of smear-negative pulmonary tuberculosis in Kampala, Uganda. 2012. PMID: 22947399


  113. Kalema N, Boon SD, Cattamanchi A, Davis JL, Andama A, Katagira W, Everett C, Walter N, Byanyima P, Kaswabuli S, Worodria W, Huang L. Oral antimicrobial rinse to reduce mycobacterial culture contamination among tuberculosis suspects in Uganda: a prospective study. 2012. PMID: 22808020


  114. Iwai S, Fei M, Huang D, Fong S, Subramanian A, Grieco K, Lynch SV, Huang L. Oral and airway microbiota in HIV-infected pneumonia patients. 2012. PMID: 22760045


  115. Cattamanchi A, Ssewenyana I, Nabatanzi R, Miller CR, Den Boon S, Davis JL, Andama A, Worodria W, Yoo SD, Cao H, Huang L. Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV-infected patients. 2012. PMID: 22745833


  116. Feldman MD, Steinauer JE, Khalili M, Huang L, Kahn JS, Lee KA, Creasman J, Brown JS. A mentor development program for clinical translational science faculty leads to sustained, improved confidence in mentoring skills. 2012. PMID: 22883616


  117. Taylor SM, Meshnick SR, Worodria W, Andama A, Davis JL, Cattamanchi A, den Boon S, Yoo SD, Goodman CD, Huang L. Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia. 2011. PMID: 22153850


  118. Metcalfe JZ, Everett CK, Steingart KR, Cattamanchi A, Huang L, Hopewell PC, Pai M. Interferon-? release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysis. 2011. PMID: 21996694


  119. Worodria W, Anderson J, Cattamanchi A, Davis JL, den Boon S, Andama A, Yoo SD, Joloba M, Huang L, Kato-Maeda M. The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country. 2011. PMID: 22073241


  121. Kisembo HN, Boon SD, Davis JL, Okello R, Worodria W, Cattamanchi A, Huang L, Kawooya MG. Chest radiographic findings of pulmonary tuberculosis in severely immunocompromised patients with the human immunodeficiency virus. 2011. PMID: 21976629


  122. Yoo SD, Cattamanchi A, Den Boon S, Worodria W, Kisembo H, Huang L, Davis JL. Clinical significance of normal chest radiographs among HIV-seropositive patients with suspected tuberculosis in Uganda. 2011. PMID: 21518124


  123. Akgün KM, Huang L, Morris A, Justice AC, Pisani M, Crothers K. Critical illness in HIV-infected patients in the era of combination antiretroviral therapy. 2011. PMID: 21653532


  124. Morris A, George MP, Crothers K, Huang L, Lucht L, Kessinger C, Kleerup EC. HIV and chronic obstructive pulmonary disease: is it worse and why? 2011. PMID: 21653535


  125. Huang L, Cattamanchi A, Davis JL, den Boon S, Kovacs J, Meshnick S, Miller RF, Walzer PD, Worodria W, Masur H. HIV-associated Pneumocystis pneumonia. 2011. PMID: 21653531


  126. Crothers K, Thompson BW, Burkhardt K, Morris A, Flores SC, Diaz PT, Chaisson RE, Kirk GD, Rom WN, Huang L. HIV-associated lung infections and complications in the era of combination antiretroviral therapy. 2011. PMID: 21653528


  127. Dhanireddy S, Harrington RD, Crane HM, Gingo MR, Morris A, Huang L, Crothers K. Pandemic (H1N1) 2009 and HIV Infection. 2011. PMID: 21749797


  128. Almodovar S, Hsue PY, Morelli J, Huang L, Flores SC. Pathogenesis of HIV-associated pulmonary hypertension: potential role of HIV-1 Nef. 2011. PMID: 21653533


  129. Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, Huang L, Caceres T, Mehdiyev R, Raymond L, Whitelaw A, Sagadevan K, Alexander H, Albert H, Cobelens F, Cox H, Alland D, Perkins MD. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. 2011. PMID: 21507477


  130. Davis J, Katamba A, Vasquez J, Crawford E, Sserwanga A, Kakeeto S, Kizito F, Dorsey G, den Boon S, Vittinghoff E, Huang L, Adatu F, Kamya MR, Hopewell PC, Cattamanchi A. Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic services. Volume 184 of Issue 3. 2011. PMID: 21471088


  132. Cattamanchi A, Smith R, Steingart KR, Metcalfe JZ, Date A, Coleman C, Marston BJ, Huang L, Hopewell PC, Pai M. Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis. 2011. PMID: 21239993


  134. Davis JL, Huang L, Worodria W, Masur H, Cattamanchi A, Huber C, Miller C, Conville PS, Murray P, Kovacs JA. Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort study. 2011. PMID: 21298001


  135. Djawe K, Huang L, Daly KR, Levin L, Koch J, Schwartzman A, Fong S, Roth B, Subramanian A, Grieco K, Jarlsberg L, Walzer PD. Serum antibody levels to the Pneumocystis jirovecii major surface glycoprotein in the diagnosis of P. jirovecii pneumonia in HIV+ patients. 2010. PMID: 21151564


  136. Kyeyune R, den Boon S, Cattamanchi A, Davis JL, Worodria W, Yoo SD, Huang L. Causes of early mortality in HIV-infected TB suspects in an East African referral hospital. 2010. PMID: 21105258


  137. Crothers K, Huang L, Goulet JL, Goetz MB, Brown ST, Rodriguez-Barradas MC, Oursler KK, Rimland D, Gibert CL, Butt AA, Justice AC. HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era. 2010. PMID: 20851926


  138. Cattamanchi A, Huang L, Worodria W, den Boon S, Kalema N, Katagira W, Byanyima P, Yoo S, Matovu J, Hopewell PC, Davis JL. Integrated strategies to optimize sputum smear microscopy: a prospective observational study. 2010. PMID: 20851925


  139. Worodria W, Davis JL, Cattamanchi A, Andama A, den Boon S, Yoo SD, Hopewell PC, Huang L. Bronchoscopy is useful for diagnosing smear-negative tuberculosis in HIV-infected patients. 2010. PMID: 20675782


  140. Deok-jong Yoo S, Worodria W, Davis JL, Cattamanchi A, den Boon S, Kyeyune R, Kisembo H, Huang L. The prevalence and clinical course of HIV-associated pulmonary cryptococcosis in Uganda. 2010. PMID: 20150818


  141. Everett CK, Fei MW, Huang L. Respiratory emergencies in HIV-infected persons. 2010. PMID: 20413012


  142. Cattamanchi A, Davis JL, Pai M, Huang L, Hopewell PC, Steingart KR. Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis? 2010. PMID: 20421442


  143. Davis JL, Worodria W, Kisembo H, Metcalfe JZ, Cattamanchi A, Kawooya M, Kyeyune R, den Boon S, Powell K, Okello R, Yoo S, Huang L. Clinical and radiographic factors do not accurately diagnose smear-negative tuberculosis in HIV-infected inpatients in Uganda: a cross-sectional study. 2010. PMID: 20361038


  144. Cattamanchi A, Ssewenyana I, Davis JL, Huang L, Worodria W, den Boon S, Yoo S, Andama A, Hopewell PC, Cao H. Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection. 2010. PMID: 20302657


  145. Klatser P, Anthony R, den Hertog A, Leeflang M, Boer K. Misleading conclusion. 2010. PMID: 20132633


  146. Calderon EJ, Dei-Cas E. Pneumocystis infection: unraveling the colonization-to-disease shift. 2010. PMID: 20192679


  148. Ripamonti C, Orenstein A, Kutty G, Huang L, Schuhegger R, Sing A, Fantoni G, Atzori C, Vinton C, Huber C, Conville PS, Kovacs JA. Restriction fragment length polymorphism typing demonstrates substantial diversity among Pneumocystis jirovecii isolates. 2009. PMID: 19795979


  149. Fei MW, Kim EJ, Sant CA, Jarlsberg LG, Davis JL, Swartzman A, Huang L. Predicting mortality from HIV-associated Pneumocystis pneumonia at illness presentation: an observational cohort study. 2009. PMID: 19825785


  150. Tipirneni R, Daly KR, Jarlsberg LG, Koch JV, Swartzman A, Roth BM, Walzer PD, Huang L. Healthcare worker occupation and immune response to Pneumocystis jirovecii. 2009. PMID: 19861050


  151. Cattamanchi A, Davis JL, Worodria W, den Boon S, Yoo S, Matovu J, Kiidha J, Nankya F, Kyeyune R, Byanyima P, Andama A, Joloba M, Osmond DH, Hopewell PC, Huang L. Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting. 2009. PMID: 19723403


  153. Powell K, Huang L. The ART of caring for patients with HIV infection in the ICU. 2009. PMID: 19636534


  154. George MP, Kannass M, Huang L, Sciurba FC, Morris A. Respiratory symptoms and airway obstruction in HIV-infected subjects in the HAART era. 2009. PMID: 19621086


  155. Andama AO, Cattamanchi A, Davis JL, den Boon S, Worodria W, Huang L. Modified Giemsa method for confirmation of Pneumocystis pneumonia in low-income countries. 2009. PMID: 21691388


  156. Feldman MD, Huang L, Guglielmo BJ, Jordan R, Kahn J, Creasman JM, Wiener-Kronish JP, Lee KA, Tehrani A, Yaffe K, Brown JS. Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development Program. 2009. PMID: 19774102


  157. Cattamanchi A, Dowdy DW, Davis JL, Worodria W, Yoo S, Joloba M, Matovu J, Hopewell PC, Huang L. Sensitivity of direct versus concentrated sputum smear microscopy in HIV-infected patients suspected of having pulmonary tuberculosis. 2009. PMID: 19419537


  158. Huang L, Crothers K. HIV-associated opportunistic pneumonias. 2009. PMID: 19645867


  160. Crothers, K, Huang, L, and Morris, A.. Non-infectious pulmonary diseases in HIV 2009. PMID:


  161. Heffelfinger JD, Voetsch AC, Nakamura GV, Sullivan PS, McNaghten AD, Huang L. Nonadherence to primary prophylaxis against Pneumocystis jirovecii pneumonia. 2009. PMID: 19319199


  163. Davis JL, Huang L, Kovacs JA, Masur H, Murray P, Havlir DV, Worodria WO, Charlebois ED, Srikantiah P, Cattamanchi A, Huber C, Shea YR, Chow Y, Fischer SH. Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosis. 2009. PMID: 19207077


  164. Chakravorty S, Tyagi JS, Cattamanchi A, Davis JL, Worodria W, Yoo S, Huang L. Performance of modified universal sample processing method in a field study in Uganda. 2009. PMID: 19189927


  165. Fei MW, Sant CA, Kim EJ, Swartzman A, Davis JL, Jarlsberg LG, Huang L. Severity and outcomes of Pneumocystis pneumonia in patients newly diagnosed with HIV infection: an observational cohort study. 2009. PMID: 19521925


  167. Cattamanchi A, Davis JL, Worodria W, Yoo S, Matovu J, Kiidha J, Nankya F, Kyeyune R, Andama A, Joloba M, Osmond D, Hopewell P, Huang L. Poor performance of universal sample processing method for diagnosis of pulmonary tuberculosis by smear microscopy and culture in Uganda. 2008. PMID: 18701657


  169. Davis JL, Morris A, Kallet RH, Powell K, Chi AS, Bensley M, Luce JM, Huang L. Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury. 2008. PMID: 18535118


  170. Hsue PY, Deeks SG, Farah HH, Palav S, Ahmed SY, Schnell A, Ellman AB, Huang L, Dollard SC, Martin JN. Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertension. 2008. PMID: 18427200


  171. Davis JL, Fei M, Huang L. Respiratory infection complicating HIV infection. 2008. PMID: 18317044


  172. Morris A, Wei K, Afshar K, Huang L. Epidemiology and clinical significance of pneumocystis colonization. 2008. PMID: 18171279


  173. Fei, M
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  174. Davis JL, Welsh DA, Beard CB, Jones JL, Lawrence GG, Fox MR, Crothers K, Morris A, Charbonnet D, Swartzman A, Huang L. Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia. 2007. PMID: 18024536


  175. Davis JL, Shum AK, Huang L. A 36-year-old man with AIDS and relapsing, nonproductive cough. 2007. PMID: 17565026


  177. de Oliveira A, Unnasch TR, Crothers K, Eiser S, Zucchi P, Moir J, Beard CB, Lawrence GG, Huang L. Performance of a molecular viability assay for the diagnosis of Pneumocystis pneumonia in HIV-infected patients. 2006. PMID: 17049800


  178. Saccente M. Intensive care of patients with HIV infection. 2006. PMID: 17035660


  179. Daly KR, Huang L, Morris A, Koch J, Crothers K, Levin L, Eiser S, Satwah S, Zucchi P, Walzer PD. Antibody response to Pneumocystis jirovecii major surface glycoprotein. 2006. PMID: 16965702


  180. Huang L, Quartin A, Jones D, Havlir DV. Intensive care of patients with HIV infection. 2006. PMID: 16837681


  183. Huang L, Welsh DA, Miller RF, Beard CB, Lawrence GG, Fox M, Swartzman A, Bensley MR, Carbonnet D, Davis JL, Chi A, Yoo BJ, Jones JL. Pneumocystis jirovecii dihydropteroate synthase gene mutations and human immunodeficiency virus-associated Pneumocystis pneumonia. 2006. PMID: 17169022


  184. Huang L, Murray JF. A rose is a rose: but what about Pneumocystis pneumonia? 2005. PMID: 16466049


  185. Beard CB, Fox MR, Lawrence GG, Guarner J, Hanzlick RL, Huang L, del Rio C, Rimland D, Duchin JS, Colley DG. Genetic differences in Pneumocystis isolates recovered from immunocompetent infants and from adults with AIDS: Epidemiological Implications. 2005. PMID: 16235182


  186. Crothers K, Beard CB, Turner J, Groner G, Fox M, Morris A, Eiser S, Huang L. Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations. 2005. PMID: 15867494


  187. Morris A, Lundgren JD, Masur H, Walzer PD, Hanson DL, Frederick T, Huang L, Beard CB, Kaplan JE. Current epidemiology of Pneumocystis pneumonia. 2004. PMID: 15504255


  188. Huang L, Crothers K, Atzori C, Benfield T, Miller R, Rabodonirina M, Helweg-Larsen J. Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance. 2004. PMID: 15504256


  190. Miller R, Huang L. Pneumocystis jirovecii infection. 2004. PMID: 15333844


  192. Morris A, Sciurba FC, Lebedeva IP, Githaiga A, Elliott WM, Hogg JC, Huang L, Norris KA. Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization. 2004. PMID: 15117741


  193. Larsen HH, Huang L, Kovacs JA, Crothers K, Silcott VA, Morris A, Turner JR, Beard CB, Masur H, Fischer SH. A prospective, blinded study of quantitative touch-down polymerase chain reaction using oral-wash samples for diagnosis of Pneumocystis pneumonia in HIV-infected patients. 2004. PMID: 15116305


  195. Morris DG, Jasmer RM, Huang L, Gotway MB, Nishimura S, King TE. Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence. 2003. PMID: 12970019


  196. Lin X, Irwin D, Kanazawa S, Huang L, Romeo J, Yen TS, Peterlin BM. Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir. 2003. PMID: 12857891


  199. Huang L, Crothers K, Morris A, Groner G, Fox M, Turner JR, Merrifield C, Eiser S, Zucchi P, Beard CB. Pneumocystis colonization in HIV-infected patients. 2003. PMID: 14736184


  200. Crothers K, Huang L, Morris A, Fox M, Groner G, Turner JR, Merrifield C, Eiser S, Friedly J, Gravari E, Zucchi P, Beard CB. Pneumocystis dihydropteroate synthase mutations in patients with Pneumocystis pneumonia who are newly diagnosed with HIV infection. 2003. PMID: 14736181


  201. Ma L, Kutty G, Jia Q, Imamichi H, Huang L, Atzori C, Beckers P, Groner G, Beard CB, Kovacs JA. Analysis of variation in tandem repeats in the intron of the major surface glycoprotein expression site of the human form of Pneumocystis carinii. 2002. PMID: 12447742


  203. Morris A, Creasman J, Turner J, Luce JM, Wachter RM, Huang L. Intensive care of human immunodeficiency virus-infected patients during the era of highly active antiretroviral therapy. 2002. PMID: 12153955


  204. Nimri LF, Moura IN, Huang L, del Rio C, Rimland D, Duchin JS, Dotson EM, Beard CB. Genetic diversity of Pneumocystis carinii f. sp. hominis based on variations in nucleotide sequences of internal transcribed spacers of rRNA genes. 2002. PMID: 11923323


  205. Morris A, Beard CB, Huang L. Update on the epidemiology and transmission of Pneumocystis carinii. 2002. PMID: 11825780


  206. Beck JM, Rosen MJ, Peavy HH. Pulmonary complications of HIV infection. Report of the Fourth NHLBI Workshop. 2001. PMID: 11739145


  207. Navin TR, Beard CB, Huang L, del Rio C, Lee S, Pieniazek NJ, Carter JL, Le T, Hightower A, Rimland D. Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study. 2001. PMID: 11520525


  208. Soumelis V, Scott I, Gheyas F, Bouhour D, Cozon G, Cotte L, Huang L, Levy JA, Liu YJ. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. 2001. PMID: 11493432


  209. Kazanjian P, Armstrong W, Hossler PA, Lee CH, Huang L, Beard CB, Carter J, Crane L, Duchin J, Burman W, Richardson J, Meshnick SR. Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS. 2001. PMID: 11181161


  210. Meshnick SR, Hossler PA, Enger KS, Kazanjian P, Rest JS, Mindell D, Li B, Lee CH, Nimri LF, Carter JL, Beard CB, Huang L. Distribution of DHPS mutations among ITS subtypes of P. carinii f. sp. hominis. 2001. PMID: 11906022


  211. Huang L, Friedly J, Morris AM, Carter JL, Turner JR, Merrifield C, Navin TR, Beard CB. Pneumocystis carinii dihydropteroate synthase genotypes in HIV-infected persons residing in San Francisco: possible implications for disease transmission. 2001. PMID: 11906028


  213. Huang L, Hecht FM. Why does Pneumocystis carinii pneumonia still occur? 2000. PMID: 11101076


  215. Huang L, Beard CB, Creasman J, Levy D, Duchin JS, Lee S, Pieniazek N, Carter JL, del Rio C, Rimland D, Navin TR. Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene. 2000. PMID: 10979917


  216. Morris AM, Huang L, Bacchetti P, Turner J, Hopewell PC, Wallace JM, Kvale PA, Rosen MJ, Glassroth J, Reichman LB, Stansell JD. Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons. The Pulmonary Complications of HIV Infection Study Group. 2000. PMID: 10934095


  218. Beard CB, Carter JL, Keely SP, Huang L, Pieniazek NJ, Moura IN, Roberts JM, Hightower AW, Bens MS, Freeman AR, Lee S, Stringer JR, Duchin JS, del Rio C, Rimland D, Baughman RP, Levy DA, Dietz VJ, Simon P, Navin TR. Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission. 2000. PMID: 10827116


  219. Jasmer RM, Edinburgh KJ, Thompson A, Gotway MB, Creasman JM, Webb WR, Huang L. Clinical and radiographic predictors of the etiology of pulmonary nodules in HIV-infected patients. 2000. PMID: 10767234


  220. Edinburgh KJ, Jasmer RM, Huang L, Reddy GP, Chung MH, Thompson A, Halvorsen RA, Webb RA. Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes. 2000. PMID: 10671590


  221. Huang L, Stansell J, Osmond D, Turner J, Shafer KP, Fulkerson W, Kvale P, Wallace J, Rosen M, Glassroth J, Reichman L, Hopewell P. Performance of an algorithm to detect Pneumocystis carinii pneumonia in symptomatic HIV-infected persons. Pulmonary Complications of HIV Infection Study Group. 1999. PMID: 10208204


  222. Horton CK, Huang L, Goozé L. Pseudallescheria boydii infection in AIDS. 1999. PMID: 10048912


  224. Holtzer CD, Jacobson MA, Hadley WK, Huang L, Stanley HD, Montanti R, Wong MK, Stansell JD. Decline in the rate of specific opportunistic infections at San Francisco General Hospital, 1994-1997. 1998. PMID: 9792398


  227. Jasmer, R
    Huang, L. TB or not TB 1997. PMID:


  229. Huang L, Stansell JD. AIDS and the lung. 1996. PMID: 8676614


  230. Huang L, Schnapp LM, Gruden JF, Hopewell PC, Stansell JD. Presentation of AIDS-related pulmonary Kaposi's sarcoma diagnosed by bronchoscopy. 1996. PMID: 8616570


  232. Huang L, Hecht FM, Stansell JD, Montanti R, Hadley WK, Hopewell PC. Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful? 1995. PMID: 7767533


  233. Gruden JF, Huang L, Webb WR, Gamsu G, Hopewell PC, Sides DM. AIDS-related Kaposi sarcoma of the lung: radiographic findings and staging system with bronchoscopic correlation. 1995. PMID: 7724781