Suzanne Noble, MD, PhD

Associate Professor

Education
M.D., 1997 - Medicine, University of California, San Francisco
Ph.D., 1995 - Graduate Division (Biochemistry), University of California, San Francisco
Postdoctoral Studies, - Graduate Division, University of California, San Francisco
Websites
Publications

  1. Merrill ED, Prudent V, Moghadam P, Rodriguez A, Hurabielle C, Wells EKC, Basso P, Scharschmidt TC, Rosenblum MD, Molofsky AB, Noble SM. The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles. 2025. PMID: 39868197


  2. Xiong EH, Zhang X, Yan H, Ward HN, Lin ZY, Wong CJ, Fu C, Gingras AC, Noble SM, Robbins N, Myers CL, Cowen LE. Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions. 2024. PMID: 39126650


  3. Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. 2023. PMID: 37535745


  4. Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, Noble SM, Cowen LE. Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence. 2023. PMID: 37500616


  5. Lash E, Prudent V, Stogios PJ, Savchenko A, Noble SM, Robbins N, Cowen LE. Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans. 2023. PMID: 36809010


  6. Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM. Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response. 2022. PMID: 36323314


  7. Noble S, Burgess SM, Strauss E. Christine Guthrie (1945-2022). 2022. PMID: 36048934


  8. Shao TY, Kakade P, Witchley JN, Frazer C, Murray KL, Ene IV, Haslam DB, Hagan T, Noble SM, Bennett RJ, Way SS. Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity. 2022. PMID: 35584674


  9. Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N, Myers CL, Cowen LE. Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets. 2021. PMID: 34764269


  10. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Adaptive immunity induces mutualism between commensal eukaryotes. 2021. PMID: 34262174


  13. Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM. A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. 2019. PMID: 31226107


  14. Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM. Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection. 2019. PMID: 30870623


  15. O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE. High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis. 2018. PMID: 30131363


  16. Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Volume 8 of Issue 1. 2017. PMID: 28928442


  17. Noble SM, Gianetti BA, Witchley JN. Candida albicans cell-type switching and functional plasticity in the mammalian host. Volume 15 of Issue 2. 2016. PMID: 27867199


  18. Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein PC. Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa. Volume 196 of Issue 9. 2014. PMID: 24532776


  20. Pande K, Chen C, Noble SM. Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism. Volume 45 of Issue 9. 2013. PMID: 23892606


  22. Chen C, Pande K, French SD, Tuch BB, Noble SM. An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Volume 10 of Issue 2. 2011. PMID: 21843869


  23. Noble SM, French S, Kohn LA, Chen V, Johnson AD. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Volume 42 of Issue 7. 2010. PMID: 20543849


  24. Hernday AD, Noble SM, Mitrovich QM, Johnson AD. Genetics and molecular biology in Candida albicans. Volume 470. 2010. PMID: 20946834


  25. Homann OR, Dea J, Noble SM, Johnson AD. A phenotypic profile of the Candida albicans regulatory network. Volume 5 of Issue 12. 2009. PMID: 20041210


  26. Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD. An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. Volume 5 of Issue 9. 2009. PMID: 19779551


  27. Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Volume 135 of Issue 1. 2008. PMID: 18854164


  28. Noble SM, Johnson AD. Genetics of Candida albicans, a diploid human fungal pathogen. Volume 41. 2007. PMID: 17614788